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Article(id=1307269620050715203, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269601637724372, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260092, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729094400000, receivedDateStr=2024-10-17, revisedDate=1753804800000, revisedDateStr=2025-07-30, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606965315, onlineDateStr=2026-09-17, pubDate=1779206400000, pubDateStr=2026-05-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606965315, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606965315, creator=13701087609, updateTime=1789606965315, updator=13701087609, issue=Issue{id=1307269601637724372, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='5', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1779206400000', pubDateStr='2026-05-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606960925, creator='13701087609', updateTime=1789606960925, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=28, endPage=35, ext={EN=ArticleExt(id=1307269620214293060, articleId=1307269620050715203, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Analysis of Differential Metabolites in Akebia Species from Different Origins Based on Untargeted Metabolomics, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

Based on metabolomics methods, this study aims to explore the differential metabolites of different primitive Chinese medicinal herbs (such as Chinese medicinal herb, Chinese medicinal herb, and Chinese medicinal herb) and screen the main metabolites identified by primitive identification.

Method:

The chemical composition of different types of Platycodon grandiflorus was analyzed by ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Principal component analysis, cluster heatmap, orthogonal partial least squares discriminant analysis, and other methods were used to compare the differences in metabolites among the three types of Platycodon grandiflorus. Differential metabolites were identified using a database.

Result:

A total of 691 compounds were identified in negative ion mode, with lipids, organic acids and their derivatives, and flavonoids being the main metabolites. Differential metabolites were significantly enriched in the flavonoid biosynthesis pathway. There are a total of 11 differential metabolites among the three groups, with flavonoids (3, 27.27%) and lipids (3, 27.27%) accounting for the largest proportion. Combined with the difference factor, rutin, anthocyanin B2, and isorhamnetin-3-O-rutinoside were identified as the three differential metabolites based on their respective origins.

Conclusion:

UPLC-Q-TOF-MS metabolomics technology can elucidate the differences in chemical composition of different basal components of Eucommia ulmoides, providing new ideas for differential analysis of different basal components of Eucommia ulmoides, and also providing references for the quality control, evaluation, and clinical use of medicinal materials of Eucommia ulmoides.

, authors=Jing LI1, Tingting HU1, Qiaoyue LI1, Jinyang LI1, Xiuquan XU1, 2, Yufan PANG1, authorsList=Jing LI, Tingting HU, Qiaoyue LI, Jinyang LI, Xiuquan XU, Yufan PANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269620562420293, articleId=1307269620050715203, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于非靶向代谢组学分析不同基原木通的差异代谢物, columnId=1303760928135213534, journalTitle=中医药学报, columnName=中药研究, runingTitle=null, highlight=null, articleAbstract=
目的：

基于代谢组学方法探究不同基原木通（木通、白木通和三叶木通）的差异代谢物，筛选基原鉴别的主要代谢物。

方法：

利用UPLC-Q-TOF-MS代谢组学技术结合多元统计分析策略，系统考察不同基原木通的化学组成特征，比较3种基原木通的代谢物差异，并借助数据库对潜在的差异标志物进行鉴定。

结果：

负离子模式下共鉴定得到691个化合物，脂质类、有机酸及其衍生物和黄酮类是主要的代谢物，差异代谢物主要显著富集于黄酮类生物合成通路。3组之间共有差异代谢物11个，其中黄酮类（3个，27.27%）和脂质类（3个，27.27%）占最大比例，结合差异倍数，将芦丁、原花青素B2、异鼠李素-3-O-芸香糖苷作为3个基原区分的差异代谢物。

结论：

UPLC-Q-TOF-MS代谢组学技术可阐明不同基原木通化学成分差异，为分析不同基原木通差异性提供思路，为木通药材的质量控制、评价及临床使用提供更加全面和科学的参考。

, authors=李静1, 胡婷婷1, 李巧月1, 李金洋1, 徐秀泉1, 2, 庞宇凡1, authorsList=李静, 胡婷婷, 李巧月, 李金洋, 徐秀泉, 庞宇凡, authorCompany=null, correspAuthors=null, authorNote=

李静（1988-），女，硕士，讲师，研究方向：中药资源开发。

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李静（1988-），女，硕士，讲师，研究方向：中药资源开发。

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李静（1988-），女，硕士，讲师，研究方向：中药资源开发。

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基于非靶向代谢组学分析不同基原木通的差异代谢物
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李静 1 , 胡婷婷 1 , 李巧月 1 , 李金洋 1 , 徐秀泉 1, 2 , 庞宇凡 1
中医药学报 | 中药研究 2026,54(5): 28-35
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中医药学报 |中药研究 2026 , 54 (5) : 28 -35
基于非靶向代谢组学分析不同基原木通的差异代谢物
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李静1, 胡婷婷1, 李巧月1, 李金洋1, 徐秀泉1, 2, 庞宇凡1
作者信息
  • 1.亳州学院，安徽 亳州 236800
  • 2.亳州学院中药原料产品研发安徽普通高校重点实验室，安徽 亳州 236800
作者简介:

李静（1988-），女，硕士，讲师，研究方向：中药资源开发。

Analysis of Differential Metabolites in Akebia Species from Different Origins Based on Untargeted Metabolomics
Jing LI1, Tingting HU1, Qiaoyue LI1, Jinyang LI1, Xiuquan XU1, 2, Yufan PANG1
Affiliations
  • 1.Bozhou University, Bozhou 236800, China
  • 2.Anhui Key Laboratory of Traditional Chinese Medicine Raw Material Product Research and Development, Bozhou University, Bozhou 236800, China
出版时间: 2026-05-20 doi: 10.19664/j.cnki.1002-2392.260092
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摘要
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目的：

基于代谢组学方法探究不同基原木通（木通、白木通和三叶木通）的差异代谢物，筛选基原鉴别的主要代谢物。

方法：

利用UPLC-Q-TOF-MS代谢组学技术结合多元统计分析策略，系统考察不同基原木通的化学组成特征，比较3种基原木通的代谢物差异，并借助数据库对潜在的差异标志物进行鉴定。

结果：

负离子模式下共鉴定得到691个化合物，脂质类、有机酸及其衍生物和黄酮类是主要的代谢物，差异代谢物主要显著富集于黄酮类生物合成通路。3组之间共有差异代谢物11个，其中黄酮类（3个，27.27%）和脂质类（3个，27.27%）占最大比例，结合差异倍数，将芦丁、原花青素B2、异鼠李素-3-O-芸香糖苷作为3个基原区分的差异代谢物。

结论：

UPLC-Q-TOF-MS代谢组学技术可阐明不同基原木通化学成分差异，为分析不同基原木通差异性提供思路，为木通药材的质量控制、评价及临床使用提供更加全面和科学的参考。

木通  /  基原  /  代谢组学  /  差异代谢物  /  黄酮类
Objective:

Based on metabolomics methods, this study aims to explore the differential metabolites of different primitive Chinese medicinal herbs (such as Chinese medicinal herb, Chinese medicinal herb, and Chinese medicinal herb) and screen the main metabolites identified by primitive identification.

Method:

The chemical composition of different types of Platycodon grandiflorus was analyzed by ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Principal component analysis, cluster heatmap, orthogonal partial least squares discriminant analysis, and other methods were used to compare the differences in metabolites among the three types of Platycodon grandiflorus. Differential metabolites were identified using a database.

Result:

A total of 691 compounds were identified in negative ion mode, with lipids, organic acids and their derivatives, and flavonoids being the main metabolites. Differential metabolites were significantly enriched in the flavonoid biosynthesis pathway. There are a total of 11 differential metabolites among the three groups, with flavonoids (3, 27.27%) and lipids (3, 27.27%) accounting for the largest proportion. Combined with the difference factor, rutin, anthocyanin B2, and isorhamnetin-3-O-rutinoside were identified as the three differential metabolites based on their respective origins.

Conclusion:

UPLC-Q-TOF-MS metabolomics technology can elucidate the differences in chemical composition of different basal components of Eucommia ulmoides, providing new ideas for differential analysis of different basal components of Eucommia ulmoides, and also providing references for the quality control, evaluation, and clinical use of medicinal materials of Eucommia ulmoides.

Akebia  /  Multiple botanical origins  /  Metabolomics  /  Differential metabolites  /  Flavonoids
李静, 胡婷婷, 李巧月, 李金洋, 徐秀泉, 庞宇凡. 基于非靶向代谢组学分析不同基原木通的差异代谢物. 中医药学报, 2026 , 54 (5) : 28 -35 . DOI: 10.19664/j.cnki.1002-2392.260092
Jing LI, Tingting HU, Qiaoyue LI, Jinyang LI, Xiuquan XU, Yufan PANG. Analysis of Differential Metabolites in Akebia Species from Different Origins Based on Untargeted Metabolomics[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (5) : 28 -35 . DOI: 10.19664/j.cnki.1002-2392.260092
基金
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  • 安徽省高校自然科学研究项目(2023AH040316; 2024AH051306)
  • 亳州学院创新创业训练项目(2023XJXM120; 2023XTXM088)
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doi: 10.19664/j.cnki.1002-2392.260092
  • 接收时间：2024-10-17
  • 首发时间：2026-09-17
  • 出版时间：2026-05-20
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  • 收稿日期：2024-10-17
  • 修回日期：2025-07-30
基金
安徽省高校自然科学研究项目(2023AH040316; 2024AH051306)
亳州学院创新创业训练项目(2023XJXM120; 2023XTXM088)
作者信息
    1.亳州学院，安徽 亳州 236800
    2.亳州学院中药原料产品研发安徽普通高校重点实验室，安徽 亳州 236800
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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260092
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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