Article(id=1307269612219945417, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269601637724372, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260094, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1734451200000, receivedDateStr=2024-12-18, revisedDate=1760544000000, revisedDateStr=2025-10-16, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606963448, onlineDateStr=2026-09-17, pubDate=1779206400000, pubDateStr=2026-05-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606963448, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606963448, creator=13701087609, updateTime=1789606963448, updator=13701087609, issue=Issue{id=1307269601637724372, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='5', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1779206400000', pubDateStr='2026-05-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606960925, creator='13701087609', updateTime=1789606960925, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=40, endPage=44, ext={EN=ArticleExt(id=1307269612421272010, articleId=1307269612219945417, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Exploration on the Phenomenon of Phenotypic Transition Following Biological Agent Treatment in Psoriasis, Eczema Based on the Theory of Xuanfu Qi Fluids, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Treatment with biological agents may lead to eczema-like changes in patients with psoriasis and psoriasis-like changes in patients with eczema, and this phenotypic switching phenomenon is attracting more and more attention, whose molecular biological mechanism may be related to the dysregulation of the Th1/Th2 balance, and for which there is no clear therapeutic solution. Based on the Xuanfu qi fluids theory, this paper describes the evolution of the pathogenesis of psoriasis and eczema. In the course of treatment, the biological agents may improperly regulate qi and fluids transport, which ultimately leads to dampness on the outside and qi and blood dryness on the inside; dryness is present on the surface, while dampness is stagnant on the inside, which is manifested as the phenomenon of phenotypic transformation on the skin. For this complex dry-damp presentation, therapy must combine pungent-moistening agents to unblock the orifices with bland herbs to promote diuresis, thereby normalizing qi fluids dynamics without fostering pathogens or injuring upright qi. An illustrative case is presented to showcase this approach to managing pattern transition.

, authors=Ruohan DIAO¹, Xingwu DUAN^{1, *}, Tiange QU¹, Ye TIAN¹, Min HUANG¹, Yuexuan GAO², Huanhuan DENG¹, Xiaoting LI¹, authorsList=Ruohan DIAO, Xingwu DUAN, Tiange QU, Ye TIAN, Min HUANG, Yuexuan GAO, Huanhuan DENG, Xiaoting LI, authorCompany=null, correspAuthors=Xingwu DUAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269612765204939, articleId=1307269612219945417, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于玄府气液学说探讨银屑病、湿疹生物制剂治疗后的表型转换现象, columnId=1303760928365892493, journalTitle=中医药学报, columnName=临证体会, runingTitle=null, highlight=null, articleAbstract=

生物制剂治疗可能会导致银屑病患者出现湿疹样改变、皮炎湿疹类患者出现银屑病样改变，这种表型转换现象正在引起越来越多的关注，其分子生物学机制可能与Th1/Th2平衡失调有关，尚无明确的治疗方案。本文基于玄府气液学说，阐述银屑病、湿疹两病的病机演变。在治疗过程中，生物制剂引起气液运化调节失度，最终湿见于外，气虚血燥于内或燥现于表，湿浊胶滞于里，在肌表则表现为表型转换现象。针对这种燥湿混杂的复杂情况，治疗应辛润开玄与淡渗利玄并用，使气液恢复流通而不滋邪腻、不伤正气。并附验案一则，为表型转换的中医诊疗提供思路。

, authors=刁若涵¹, 段行武^{1, *}, 曲天歌¹, 田野¹, 黄敏¹, 高玥璇², 邓欢欢¹, 李小婷¹, authorsList=刁若涵, 段行武, 曲天歌, 田野, 黄敏, 高玥璇, 邓欢欢, 李小婷, authorCompany=null, correspAuthors=段行武, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=YOKdZ+gvayCUgc912DVrig==, magXml=iO4e4BQi5z/1mvIZKsFv/w==, pdfUrl=null, pdf=FsrSuSWkRbuBLnwr0zeXoQ==, pdfFileSize=1220558, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=Md+oPLUc9y2Cpbc2m4rX3w==, mapNumber=null, fund=null)}, authors=[Author(id=1307269613151080915, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269612219945417, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269613230772693, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269612219945417, authorId=1307269613151080915, language=EN, stringName=Ruohan DIAO, firstName=Ruohan, middleName=null, lastName=DIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269613302075862, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269612219945417, authorId=1307269613151080915, language=CN, stringName=刁若涵, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.北京中医药大学东直门医院，北京 100700, bio={"content":"

刁若涵（1997-），女，博士，住院医师，研究方向：中医药防治皮肤病的基础与临床研究。

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刁若涵（1997-），女，博士，住院医师，研究方向：中医药防治皮肤病的基础与临床研究。

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