Article(id=1307269554606989656, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269516371719010, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260125, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1751212800000, receivedDateStr=2025-06-30, revisedDate=1762185600000, revisedDateStr=2025-11-04, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606949712, onlineDateStr=2026-09-17, pubDate=1781884800000, pubDateStr=2026-06-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606949712, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606949712, creator=13701087609, updateTime=1789606949712, updator=13701087609, issue=Issue{id=1307269516371719010, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='6', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1781884800000', pubDateStr='2026-06-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606940596, creator='13701087609', updateTime=1789606940596, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=85, endPage=89, ext={EN=ArticleExt(id=1307269554791539033, articleId=1307269554606989656, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Efficacy Analysis of Dachaihu Decoction Combined with Amlodipine Besylate in Treating Hypertension Patients with Liver Fire Hyperactivity Syndrome, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the clinical effect of combination of Dachaihu Decoction and amlodipine besylate in treating hypertension with liver-fire hyperactivity syndrome.
Methods: A total of 148 hypertensive patients with liver-fire hyperactivity syndrome admitted to Pingyi County Traditional Chinese Medicine Hospital between January 2022 and January 2025 were divided into control group (n = 74, amlodipine besylate) and combined group (n = 74, Dachaihu Decoction combined with amlodipine besylate) according to the random number table method. The clinical efficacy, TCM symptoms scores and 24 h ambulatory blood pressure were compared between both groups, and the safety and quality of life in the two groups were evaluated.
Results: Compared with the control group, the clinical efficacy in the combined group was enhanced after treatment (P < 0. 05) while the scores of TCM syndromes were reduced (P <0.05). The 24 h average systolic, 24 h average diastolic blood pressures, daytime average systolic blood pressure, daytime average diastolic blood pressure, nighttime average systolic blood pressure and nighttime average diastolic blood pressure in the combined group after treatment were decreased compared with those in the control group (P < 0.05). The scores of various dimensions of quality of life brief scale were increased in the combined group after treatment (P <0.05). No significant difference was exhibited in the occurrence of adverse reactions between groups (P > 0.05).
Conclusion: Dachaihu Decoction combined with amlodipine besylate has significant efficacy in the treatment of hypertensive patients with liver-fire hyperactivity syndrome, and it can effectively reduce blood pressure, improve symptoms, and enhance the quality of life, with guaranteed safety.
, authors=Shuai ZHAO
1, Huihua QU
1, *, Yuyuan TU
2, Yue ZHANG
1, authorsList=Shuai ZHAO, Huihua QU, Yuyuan TU, Yue ZHANG, authorCompany=null, correspAuthors=Huihua QU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269555143860570, articleId=1307269554606989656, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=大柴胡汤联合苯磺酸氨氯地平治疗高血压肝火亢盛证患者的疗效分析, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探究大柴胡汤联合苯磺酸氨氯地平治疗高血压肝火亢盛证的临床效果。
方法： 将2022年1月—2025年1月平邑县中医医院收治的148例高血压肝火亢盛证患者依据随机数字表法分为对照组（74例，苯磺酸氨氯地平）和联合组（74例，大柴胡汤联合苯磺酸氨氯地平）。对比两组的临床疗效、中医证候积分、24 h动态血压，评价两组的安全性及生活质量。
结果： 与对照组相比，治疗后联合组的临床疗效提高（P < 0.05），中医证候积分降低（P < 0.05）；与对照组相比，治疗后联合组24 h平均收缩压、24 h平均舒张压，日间平均收缩压、日间平均舒张压，夜间平均收缩压和夜间平均舒张压均降低（P <0.05）；与对照组相比，治疗后联合组的生活质量简表中各维度评分升高（P < 0.05）；两组不良反应对比差异不明显（P > 0.05）。
结论： 大柴胡汤联合苯磺酸氨氯地平治疗高血压肝火亢盛证患者疗效明显，可有效降低血压，改善症状，提高生活质量，且安全性有保障。
, authors=赵帅
1, 屈会化
1, *, 涂玉媛
2, 张越
1, authorsList=赵帅, 屈会化, 涂玉媛, 张越, authorCompany=null, correspAuthors=屈会化, authorNote=
赵帅（1989-），男，硕士，主治医师，主要从事中医脉诊与经方结合的临床应用研究。
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* 屈会化（1966-），男，博士，博士研究生导师，主要从事中药炭药物质基础及作用机制研究。
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赵帅（1989-），男，硕士，主治医师，主要从事中医脉诊与经方结合的临床应用研究。
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