中医药学报

护肾降糖膏治疗脾肾阳虚型非透析糖尿病肾病患者的效果及对糖脂代谢、经络特征的影响

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李丹 , 张攀科 ^* , 王丹妮 , 孟景茜

中医药学报 | 临床研究 2026,54(6): 97-102

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中医药学报 |临床研究 2026 , 54 (6) : 97 -102

护肾降糖膏治疗脾肾阳虚型非透析糖尿病肾病患者的效果及对糖脂代谢、经络特征的影响

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李丹, 张攀科^*, 王丹妮, 孟景茜

作者信息

郑州市中医院，河南郑州 450007

通讯作者:

^* 张攀科（1980 -），男，主任医师，从事中医防治肾病、风湿病相关研究。

作者简介:

李丹（1989-），女，硕士，主治医师，从事中医防治肾病、风湿病相关研究。

Effects of Hushen Jiangtang Paste on Patients with Non-Dialysis Diabetic Nephropathy of Spleen-Kidney Yang Deficiency Type and Its Impacts on Glucose-Lipid Metabolism and Meridian Characteristics

Dan LI, Panke ZHANG^*, Danni WANG, Jingxi MENG

Affiliations

Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou 450007, China

出版时间: 2026-06-20 doi: 10.19664/j.cnki.1002-2392.260127

文章导航

摘要

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目的：

探究护肾降糖膏在脾肾阳虚型非透析糖尿病肾病患者中的效果。

方法：

选取郑州市中医院肾病风湿科、糖尿病科2023年4月—2025年1月门诊及住院非透析糖尿病肾病患者为研究对象，共93例，抽签法分为颗粒组46例和膏剂组47例。研究过程中，共有3例退出或失访，其中，颗粒组1例因不愿继续配合治疗退出；膏剂组1例失访，1例自动退出，最终颗粒组45例、膏剂组45例完成试验。颗粒组给予尿毒清颗粒（无糖型）口服，膏剂组给予护肾降糖膏口服。对比两组临床疗效、中医证候积分、糖脂代谢、蛋白尿、肾功能、经络特征及不良反应。

结果：

膏剂组临床总有效率为91.11% （41/45）高于颗粒组75.56%（34/45）（P <0.05）。两组治疗24周后全身浮肿、面色㿠白、畏寒肢冷、腰脊冷痛、精神萎靡评分较治疗前降低（P < 0.05），且膏剂组低于颗粒组（P < 0.05）。两组治疗24周后TC、TG、LDL-C、FBG、HbA1c水平较治疗前降低（P < 0.05），且膏剂组低于颗粒组（P < 0.05）。颗粒组治疗前、治疗24周后Scr水平经比较差异无统计学意义（P > 0.05）；膏剂组治疗24周后Scr水平较治疗前降低（P <0.05）；膏剂组治疗24周后Scr水平低于颗粒组（P < 0.05）；两组治疗24周后mAlb、24h UTP、BUN水平较治疗前降低（P < 0.05），且膏剂组低于颗粒组（P < 0.05）。两组治疗24周后体能、阴/阳经络能量指数水平较治疗前升高（P < 0.05），且膏剂组高于颗粒组（P < 0.05）；上/下、自律神经系统、左/右经络能量指数水平较治疗前降低（P < 0.05），且膏剂组低于颗粒组（P < 0.05）。经Fisher确切概率法检验，膏剂组不良反应发生率2.22% （1/45）与颗粒组6.67% （3/45）差异无统计学意义（P > 0.05）。

结论：

护肾降糖膏可调节脾肾阳虚型非透析糖尿病肾病患者糖脂代谢与蛋白尿、肾功能，改善经络特征，降低中医证候积分，安全性良好，提高临床疗效。

关键词

护肾降糖膏 / 糖尿病肾病 / 肾功能 / 经络特征

Abstract

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Objective:

To explore the effect of Hushen Jiangtang paste in non dialysis diabetes nephropathy patients with spleen kidney yang deficiency.

Methods:

Totally 93 patients with non dialysis diabetes nephropathy were selected from the department of nephrology and rheumatology and the department of diabetes in Zhengzhou Hospital of Traditional Chinese Medicine from April 2023 to January 2025. They were divided into the granule group (n = 46) and the paste group (n=47) by lot drawing. During the research process, a total of 3 cases withdrew or were lost to follow-up. Among them, one case in the particle group withdrew due to unwillingness to continue cooperating with treatment; One case was lost to follow-up in the paste group, and one case automatically withdrew. Finally, there were 45 cases in the granule group and 45 cases in the paste group. The granule group was given Urinary Detoxification Granules (sugar free type) orally, while the ointment group was given Hushen Jiangtang paste orally. Compare the clinical efficacy, TCM syndrome score, glucose and lipid metabolism, proteinuria, renal function, meridian characteristics, and adverse reactions between two groups.

Results:

The total clinical effective rate of the ointment group was 91.11% (41/45), which was higher than that of the granule group 75.56% (34/45) (P < 0.05). After 24 weeks of treatment, the two groups showed a decrease in overall swelling, pale complexion, cold limbs, cold and painful waist and spine, and mental fatigue scores compared to before treatment(P < 0.05). The plaster group was lower than the granule group (P < 0.05). After 24 weeks of treatment, the levels of TC, TG, LDL-C, FBG, and HbA1c in both groups decreased compared to before treatment(P < 0.05), and the paste group was lower than the granule group (P <0.05). There was no significant difference in Scr levels between the particle group before treatment and 24 weeks after treatment (P > 0.05) ; The Scr level in the ointment group decreased after 24 weeks of treatment compared to before treatment (P < 0.05) ; After 24 weeks of treatment, the Scr level in the ointment group was lower than that in the granule group (P < 0.05) ; After 24 weeks of treatment, the levels of mAlb, 24-hour urine protein quantification(24h UTP), and BUN in both groups decreased compared to before treatment(P < 0.05), and the paste group was lower than the granule group (P <0.05). After 24 weeks of treatment, the physical fitness and Yin/Yang meridian energy index levels of the two groups increased compared to before treatment(P < 0.05), with the ointment group higher than the granule group (P < 0.05); The energy index levels of the upper/lower, autonomic nervous system (P < 0.05), and left/right meridians decreased compared to before treatment(P < 0.05), and the ointment group was lower than the granule group (P < 0.05). According to Fisher's exact probability test, there was no significant difference in the incidence of adverse reactions between the paste group (2.22%, 1/45) and the granule group (6.67%, 3/45) (P >0.05).

Conclusion:

Hushen Jiangtang paste can regulate glucose and lipid metabolism, proteinuria, and renal function in non dialysis diabetes nephropathy patients with spleen and kidney yang deficiency, improve the characteristics of meridians, regulate TCM syndrome scores, and has good safety and improve clinical efficacy.

Key words

Hushen Jiangtang Paste / Diabetic nephropathy / Renal function / Meridian characteristics

引用本文

李丹, 张攀科, 王丹妮, 孟景茜. 护肾降糖膏治疗脾肾阳虚型非透析糖尿病肾病患者的效果及对糖脂代谢、经络特征的影响. 中医药学报, 2026 , 54 (6) : 97 -102 . DOI: 10.19664/j.cnki.1002-2392.260127

Dan LI, Panke ZHANG, Danni WANG, Jingxi MENG. Effects of Hushen Jiangtang Paste on Patients with Non-Dialysis Diabetic Nephropathy of Spleen-Kidney Yang Deficiency Type and Its Impacts on Glucose-Lipid Metabolism and Meridian Characteristics[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (6) : 97 -102 . DOI: 10.19664/j.cnki.1002-2392.260127

基金

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河南省中医药科学研究专项课题(2023ZY2149)

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2026年第54卷第6期

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文章信息

doi: 10.19664/j.cnki.1002-2392.260127

接收时间：2025-04-22
首发时间：2026-09-17
出版时间：2026-06-20

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收稿日期：2025-04-22
修回日期：2025-12-12

基金

河南省中医药科学研究专项课题(2023ZY2149)

作者信息

郑州市中医院，河南郑州 450007

通讯作者:

^* 张攀科（1980 -），男，主任医师，从事中医防治肾病、风湿病相关研究。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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