Article(id=1307269544498712926, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269516371719010, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260129, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1722528000000, receivedDateStr=2024-08-02, revisedDate=1740931200000, revisedDateStr=2025-03-03, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606947302, onlineDateStr=2026-09-17, pubDate=1781884800000, pubDateStr=2026-06-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606947302, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606947302, creator=13701087609, updateTime=1789606947302, updator=13701087609, issue=Issue{id=1307269516371719010, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='6', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1781884800000', pubDateStr='2026-06-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606940596, creator='13701087609', updateTime=1789606940596, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=108, endPage=112, ext={EN=ArticleExt(id=1307269544649707871, articleId=1307269544498712926, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effects of Gegen Decoction Combined with Probiotic Regimen on Symptom Scores, Time to Negativity of Fecal Reducing Substances, and Fecal pH Changes in Pediatric Diarrhea, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the effects of Gegen Decoction combined with probiotics on symptom scores, time to negative conversion of fecal reducing substances, fecal pH value, and microbiome-related indicators in pediatric acute diarrhea.
Methods: A total of 98 children with acute diarrhea treated at Qinhuangdao Hospital of Traditional Chinese Medicine from January 2024 to July 2024 were randomly divided into an experimental group (Gegen Decoction Granules + probiotics) and a control group (probiotics alone), with 49 cases in each group. During follow-up, 3 cases dropped out in the experimental group and 2 cases in the control group, resulting in 46 cases in the experimental group and 47 cases in the control group completing the study. Both groups received oral rehydration and dietary management according to clinical guidelines. The treatment duration was 5 days. Traditional Chinese medicine (TCM) syndrome scores, time to negative conversion of fecal reducing substances, fecal pH value, number of bowel movements within 24 hours, fecal calprotectin, short-chain fatty acids (SCFAs), and fecal secretory immunoglobulin A (sIgA) levels were compared between the two groups before and after treatment. Adverse events were also recorded.
Results: The experimental group showed significantly greater improvements than the control group in terms of symptom score reduction, time to negative conversion of fecal reducing substances, restoration of fecal pH value, increase in total SCFAs, butyrate proportion, and fecal sIgA, as well as reduction in fecal calprotectin (P < 0.05, P < 0.01). The overall response rate was 93.48% (43/46) in the experimental group and 80.85% (38/47) in the control group (P <0.05). There was no significant difference in the incidence of adverse events between the two groups (P > 0.05).
Conclusion: Gegen Decoction combined with probiotics can significantly alleviate symptoms of acute diarrhea in children, promote recovery of carbohydrate absorption, correct the acidic intestinal environment, and modulate microbiome and mucosal immunity indicators, with a favorable safety profile. It represents an effective integrated treatment strategy.
, authors=Hongmei LI, Song LI, Yanling WANG, authorsList=Hongmei LI, Song LI, Yanling WANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269544947503456, articleId=1307269544498712926, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=葛根汤联合益生菌方案对小儿急性腹泻症状积分、粪便还原物质转阴时间与粪pH值变化的影响, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的: 探讨葛根汤联合益生菌对小儿急性腹泻症状积分、粪便还原物质转阴时间、粪pH值及微生态相关指标的影响。
方法: 选取2024年1月—2024年7月秦皇岛市中医医院就诊的急性腹泻患儿98例,随机分为试验组(给予葛根汤颗粒+益生菌)与对照组(单用益生菌),各49例,随访期间试验组脱落3例,对照组脱落2例,最终试验组46例、对照组47例完成研究。两组均按指南给予口服补液与饮食管理,疗程5 d。比较两组治疗前后中医证候积分、粪便还原物质转阴时间、粪pH值、24 h大便次数、粪钙卫蛋白、短链脂肪酸(SCFAs)及粪sIgA水平,并记录不良事件。
结果: 试验组在症状积分改善、粪便还原物质转阴时间、粪pH值恢复、SCFAs总量、丁酸比例及粪sIgA升高、钙卫蛋白降低等方面均优于对照组(P < 0.05,P < 0.01),总有效率试验组为93.48% (43/46),对照组为80.85% (38/47) (P <0.05)。两组不良事件发生率无显著差异(P > 0.05)。
结论: 葛根汤联合益生菌可显著改善小儿急性腹泻症状,促进碳水化合物吸收功能恢复,纠正肠道酸性环境,并调节微生态与黏膜免疫指标,安全性良好,是一种有效的整合治疗策略。
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李红梅(1989-),女,硕士,主治中医师,主要从事针灸学基础和临床应用研究。
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