Article(id=1307269539742372154, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269516371719010, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260121, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1739980800000, receivedDateStr=2025-02-20, revisedDate=1760976000000, revisedDateStr=2025-10-21, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606946168, onlineDateStr=2026-09-17, pubDate=1781884800000, pubDateStr=2026-06-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606946168, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606946168, creator=13701087609, updateTime=1789606946168, updator=13701087609, issue=Issue{id=1307269516371719010, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='6', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1781884800000', pubDateStr='2026-06-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606940596, creator='13701087609', updateTime=1789606940596, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=64, endPage=69, ext={EN=ArticleExt(id=1307269539926921531, articleId=1307269539742372154, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Clinical Efficacy of Huatan Xiaoyu Formula in the Treatment of Gastric Precancerous Lesions and Its Effect on Pepsin and Circulating Tumor Cells, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the clinical efficacy of Huatan Xiaoyu Formula in the treatment of gastric precancerous lesions and its effect on pepsin and circulating tumor cells (CTC).
Method: A total of 110 gastric precancerous lesions patients with syndrome of phlegm-and-blood stasis obstructing collaterals who received treatment in the First Affiliated Hospital of Nanjing Medical University from January 2022 to January 2024 were randomly divided into two groups: the conventional group (n = 55) and the Huatan Xiaoyu Formula group (n = 55). Compare the efficacy of two groups of patients, including symptom scores, laboratory indicators (including pepsinogen I (PGⅠ), pepsinogen Ⅱ (PGⅡ), malondialdehyde (MDA), superoxide dismutase (SOD), epidermal growth factor (EGF), tumor necrosis factor a (TNF-α)), and positive detection rate of CTC before and after treatment. The adverse reactions of the two groups were observed.
Results: The total effective rate of the Huatan Xiaoyu Formula group was higher than that of the conventional group (P <0.05). After treatment, both groups showed a decrease in epigastric fullness, epigastric pain, loose stools, thirst and total score, and the Huatan Xiaoyu Formula group was lower than the conventional group (P <0.05). After treatment, the score of WHOQOL-BREF in both groups was increased, and Huatan Xiaoyu Formula group was higher than that in conventional group (P <0.05). After treatment, the levels of PGⅠ and PGⅠ/Ⅱ in both groups increased, and the Huatan Xiaoyu Formula group was higher than the conventional group (P <0.05); The levels of PGII in both groups decreased, and the group of Huatan Xiaoyu Formula was lower than the conventional group (P <0.05). After treatment, the levels of MDA, TNF-α and EGF in both groups decreased, and the Huatan Xiaoyu Formula group was lower than the conventional group (P <0.05); The levels of SOD in both groups increased, and the Huatan Xiaoyu Formula group was higher than the conventional group (P < 0.05). The positive rate of CTC in the Huatan Xiaoyu Formula group was lower than that in the conventional group (P < 0.05). There was no significant difference in adverse reactions between the two groups (P >0.05).
Conclusion: Huatan Xiaoyu Formula can effectively treat gastric precancerous lesions, improve symptom scores, gastrointestinal hormone levels, reduce levels of oxidative stress related factors, body inflammation, and the positive rate of CTC.
, authors=Tao LYU, Lan WANG, Xiaoke FENG, Muxin WEI
*, authorsList=Tao LYU, Lan WANG, Xiaoke FENG, Muxin WEI, authorCompany=null, correspAuthors=Muxin WEI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269540384100668, articleId=1307269539742372154, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=化痰消瘀方治疗胃癌前病变的临床疗效及其对胃蛋白酶、循环肿瘤细胞的影响, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探讨化痰消瘀方治疗胃癌前病变的临床疗效及其对胃蛋白酶、循环肿瘤细胞（CTC）的影响。
方法： 选择2022年1月—2024年1月于南京医科大学第一附属医院接受治疗的痰瘀阻络型胃癌前病变患者110例，随机分为常规组和化痰消瘀方组，每组55例。比较两组患者疗效、治疗前后症状评分、实验室指标［包括胃蛋白酶原Ⅰ（PGⅠ）、胃蛋白酶原Ⅱ（PGⅡ）、丙二醛（MDA）、超氧化物歧化酶（SOD）、表皮生长因子（EGF）、肿瘤坏死因子α（TNF-α）］及CTC阳性检出率，观察两组的不良反应情况。
结果： 化痰消瘀方组总有效率高于常规组（P < 0.05）。治疗后，两组胃脘胀满、胃脘疼痛、便溏、口渴各项积分及总积分均降低（P < 0.05），且化痰消瘀方组低于常规组（P < 0.05）。治疗后，两组的生活质量量表（WHOQOL-BREF）评分均升高（P < 0.05），且化痰消瘀方组高于常规组（P < 0.05）；治疗后，两组PGⅠ、PGⅠ/PGⅡ水平均升高（P < 0.05），且化痰消瘀方组高于常规组（P < 0.05）；两组PGⅡ水平均降低（P < 0.05），且化痰消瘀方组低于常规组（P < 0.05）。治疗后，两组MDA、TNF-α、EGF水平均降低（P < 0.05），且化痰消瘀方组低于常规组（P < 0.05）；两组SOD水平均升高（P < 0.05），且化痰消瘀方组高于常规组（P < 0.05）。化痰消瘀方组CTC阳性率低于常规组（P < 0.05）。
结论： 化痰消瘀方可有效治疗胃癌前病变，有效改善症状评分、胃肠激素水平，降低氧化应激相关因子水平、机体炎症及CTC阳性率。
, authors=吕涛, 王岚, 冯小可, 魏睦新
*, authorsList=吕涛, 王岚, 冯小可, 魏睦新, authorCompany=null, correspAuthors=魏睦新, authorNote=
吕涛（1980-），男，硕士，副主任中医师，从事中西医结合消化病基础和临床相关研究。
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* 魏睦新（1959-），男，博士，教授，主任中医师，博士生导师，从事中西医结合消化病基础和临床相关研究。
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吕涛（1980-），男，硕士，副主任中医师，从事中西医结合消化病基础和临床相关研究。
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吕涛（1980-），男，硕士，副主任中医师，从事中西医结合消化病基础和临床相关研究。
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