中医药学报

四君温胆方结合非布司他片治疗痛风性肾病临床效果及对患者肾功能的影响

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朱学雷 ¹ , 童婉秋 ¹ , 汪节 ² , 姚贺婷 ¹

中医药学报 | 临床研究 2026,54(6): 70-74

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中医药学报 |临床研究 2026 , 54 (6) : 70 -74

四君温胆方结合非布司他片治疗痛风性肾病临床效果及对患者肾功能的影响

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朱学雷¹, 童婉秋¹, 汪节², 姚贺婷¹

作者信息

^1.安庆市第一人民医院，安徽安庆 246003

^2.安徽中医药大学第二附属医院，安徽合肥 230061

作者简介:

朱学雷（1981-），男，副主任医师，主要从事肾病相关研究。

Observation on Clinical Efficacy of Sijun Wendan Formula Combined with Febuxostat Tablets in the Treatment of Gouty Nephropathy and Its Effect on Renal Function

Xuelei ZHU¹, Wanqiu TONG¹, Jie WANG², Heting YAO¹

Affiliations

^1.Anqing First People's Hospital, Anqing 246003, China

^2.The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230061, China

出版时间: 2026-06-20 doi: 10.19664/j.cnki.1002-2392.260122

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摘要

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目的：

探讨四君温胆方结合非布司他片治疗痛风性肾病临床效果及对患者肾功能的影响。

方法：

纳入2023年1月—2025年1月安庆市第一人民医院肾内风湿科收治的148例痛风性肾病患者，采用随机数字表法将患者平均分为对照组和观察组，每组74例，对照组患者采用非布司他片治疗，观察组患者采用非布司他片+四君温胆方治疗，研究过程中对照组脱落3例，观察组脱落2例，最终观察组72例，对照组71例。观察两组患者的治疗效果、治疗前后中医证候积分（夜尿频多、腰酸腰痛、关节肿痛）、降钙素原（PCT）、C反应蛋白（CRP）、血沉（ESR）、血尿酸（UA）、尿素氮（BUN）、血肌酐（Scr）、肾小球滤过率（eGFR）、24h尿蛋白定量（24h UTP）水平及不良反应。

结果：

观察组患者临床疗效高于对照组，差异有统计学意义（P < 0.05）；两组患者治疗后中医证候积分（夜尿频多、腰酸腰痛、关节肿痛）、PCT、CRP、ESR、UA、BUN、Scr、24h UTP水平均降低（P < 0.05），eGFR水平上升（P < 0.05），观察组患者治疗后中医证候积分（夜尿频多、腰酸腰痛、关节肿痛）、PCT、CRP、ESR、UA、BUN、Scr、24h UTP水平比对照组更低（P < 0.01），eGFR水平比对照组更高（P < 0.01）；观察组总不良反应发生率低于对照组（P < 0.01）。

结论：

四君温胆方结合非布司他片治疗痛风性肾病临床效果良好，可较好改善患者病症及肾功能，治疗安全可靠。

关键词

痛风性肾病 / 四君温胆方 / 非布司他片 / 治疗效果 / 中医证候积分 / 肾功能 / 不良反应

Abstract

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Objective:

To explore the clinical efficacy of Sijun Wendan Formula combined with Febuxostat tablets in the treatment of gouty nephropathy and its impact on patients' renal function.

Method:

A total of 148 patients with gout nephropathy admitted to the Department of Nephrology and Rheumatology of Anqing First People's Hospital (from January 2023 to January 2025) were included in this study. The patients were evenly divided into two groups by the random number table method. Patients in the control group (74 cases) were treated with febuxostat tablets. Patients in the observation group (74 cases) were treated with Febuxostat Tablets + Sijun Wendan Formula. During the study, 3 cases dropped out in the control group and 2 cases in the observation group. Eventually, there were 72 cases in the observation group and 71 cases in the control group. Observe the therapeutic effects of the two groups of patients, the TCM syndrome scores before and after treatment (such as frequent nocturia, low back pain, joint swelling and pain, etc.), procalcitonin (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum uric acid (UA), blood urea nitrogen (BUN), serum creatinine (Scr), glomerular filtration rate (eGFR), and the level of 24-hour urine protein quantification (24h UTP) and adverse reactions.

Results:

The curative effect of observation group was higher than that of control group(P < 0.05); After treatment, TCM symptom scores (nocturnal frequent urination, lumbago, joint swelling pain, etc.), PCT, CRP, ESR, UA, BUN, Scr, 24h UTP levels were decreased in both groups (P < 0.05), and eGFR levels were increased(P < 0.05). After treatment, the TCM syndrome scores (nocturnal frequent urination, lumbago, joint swelling pain, etc.), PCT, CRP, ESR, UA, BUN, Scr, 24h UTP levels in observation group were lower than those in control group(P < 0.01), and eGFR levels were higher than those in control group(P < 0.05); The incidence of adverse reactions in observation group was lower than that in control group (P <0.01).

Conclusion:

The combination of Sijun Wendan Formula and Febuxostat tablets has a good clinical effect in the treatment of gouty nephropathy, and can effectively improve patients' symptoms and renal function. The treatment is safe and reliable.

Key words

Gouty nephropathy / Sijun Wendan Formula / Febuxostat tablets / Treatment effect / TCM syndrome points / Renal function / Adverse effects

引用本文

朱学雷, 童婉秋, 汪节, 姚贺婷. 四君温胆方结合非布司他片治疗痛风性肾病临床效果及对患者肾功能的影响. 中医药学报, 2026 , 54 (6) : 70 -74 . DOI: 10.19664/j.cnki.1002-2392.260122

Xuelei ZHU, Wanqiu TONG, Jie WANG, Heting YAO. Observation on Clinical Efficacy of Sijun Wendan Formula Combined with Febuxostat Tablets in the Treatment of Gouty Nephropathy and Its Effect on Renal Function[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (6) : 70 -74 . DOI: 10.19664/j.cnki.1002-2392.260122

基金

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安徽省高等学校科学研究项目(2024AH051021)

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2026年第54卷第6期

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文章信息

doi: 10.19664/j.cnki.1002-2392.260122

接收时间：2025-03-17
首发时间：2026-09-17
出版时间：2026-06-20

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收稿日期：2025-03-17
修回日期：2026-03-16

基金

安徽省高等学校科学研究项目(2024AH051021)

作者信息

^1.安庆市第一人民医院，安徽安庆 246003

^2.安徽中医药大学第二附属医院，安徽合肥 230061

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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260122

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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