Article(id=1307269507106497523, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269479684133809, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260146, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1751990400000, receivedDateStr=2025-07-09, revisedDate=1774022400000, revisedDateStr=2026-03-21, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606938387, onlineDateStr=2026-09-17, pubDate=1784476800000, pubDateStr=2026-07-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606938387, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606938387, creator=13701087609, updateTime=1789606938387, updator=13701087609, issue=Issue{id=1307269479684133809, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='7', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1784476800000', pubDateStr='2026-07-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606931849, creator='13701087609', updateTime=1789606931849, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=83, endPage=89, ext={EN=ArticleExt(id=1307269507463013364, articleId=1307269507106497523, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Correlation Analysis of Pulmonary Nodule Detection in Real-World Settings and Traditional Chinese Medicine Intervention Strategies, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate epidemiological trends in pulmonary nodule detection, characterize the distribution patterns of nodule size, morphology, anatomical location, and multiplicity, analyze gender- and age-related correlations, and propose Traditional Chinese Medicine (TCM)-based intervention strategies.
Methods: A retrospective cohort analysis was conducted using low-dose computed tomography (LDCT) data from 5 426 individuals undergoing routine health screenings at Liaocheng Hospital of Traditional Chinese Medicine from January to December 2024, identifying 4 076 patients with pulmonary nodules. Statistical analyses, including chi-square tests and Fisher's exact tests, were performed using SPSS 23.0.
Results: Pulmonary nodule detection rates demonstrated a progressive increase in recent years, peaking in 2022, followed by stabilization in 2024. Nodule characteristics revealed a predominance of solid nodules (70.6%), micro-nodules (< 10 mm, 73.3%), and multiple nodules (84.3%). Anatomically, the right upper lobe exhibited the highest nodule prevalence (20.8%). Gender-specific analysis identified significant disparities: females displayed a higher proportion of multiple nodules (P < 0.05) and ground-glass opacity (GGO) nodules (33.7% vs. 23.0% in males), whereas males exhibited a greater prevalence of solid nodules (75.5% vs. 64.7%). Age-stratified comparisons indicated markedly higher detection rates in middle-aged and elderly cohorts (≥40 years) versus younger groups (P <0.05), with larger nodules (≥10 mm) more frequent in older populations (3.0% vs. 0.8%). Notably, part-solid nodules constituted the predominant subtype among larger lesions (27.3%). TCM Constitution distribution showed that the top four biased constitutions were phlegm dampness constitution (19.9%), qi stagnation constitution (15.0%), Qi deficiency constitution (12.0%), and blood stasis constitution (10.0%).
Conclusion: Gender and age significantly influence pulmonary nodule characteristics, with part-solid morphology being disproportionately associated with larger nodules, underscoring the necessity for enhanced malignancy risk stratification in such cases. The centralized distribution of TCM Constitution further confirms the core pathogenesis of qi stagnation and phlegm coagulation. This study establishes foundational epidemiological data for pulmonary nodule management in asymptomatic populations and integrates TCM theoretical frameworks into clinical strategies. However, longitudinal follow-up and comprehensive adjustment for confounders are required to validate these findings and optimize therapeutic approaches.
, authors=Qiuyue SHI
1, Yundong DING
2, *, Xiaotong ZHANG
2, Zhipeng WANG
1, Wenrong HU
2, Yuxia LIU
2, Yanyi CUI
2, authorsList=Qiuyue SHI, Yundong DING, Xiaotong ZHANG, Zhipeng WANG, Wenrong HU, Yuxia LIU, Yanyi CUI, authorCompany=null, correspAuthors=Yundong DING, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269508188627957, articleId=1307269507106497523, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于真实世界肺结节检出情况的相关分析及中医应对策略, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 观察肺结节检出趋势，探讨其大小、性质、位置及单发/多发特征、中医体质的分布规律，分析性别、年龄与结节特征的相关性，并提出中医应对策略。
方法： 基于聊城市中医医院2024年1月—2024年12月5 426例体检人群的胸部LDCT数据，采用回顾性研究方法，最终纳入4 076例肺结节患者，通过SPSS 23.0进行统计学分析，包括卡方检验和Fisher确切检验，并统计2019—2024年聊城市中医医院参与胸部LDCT体检人群的每年肺结节检出率。
结果： 肺结节检出率近年呈上升趋势，其中在2022年上升最为明显，2023—2024年上升趋势渐趋稳定。2024年所纳入的4 076例肺结节患者中，实性结节占70.6%，微小结节占73.3%，多发结节占84.3%，右肺上叶为最常见部位（20.8%）。性别分析显示，女性多发结节比例显著高于男性（P < 0.05），且女性磨玻璃结节比例倾向更高（33.7% vs. 23.0%），男性实性结节比例倾向更高（75.5% vs. 64.7%）。年龄分层表明，中老年组（≥40岁）检出率显著高于青年组（P < 0.05），且老年组大结节比例更高（3.0% vs. 0.8%）；部分实性结节在大结节中占比最高（27.3%）。中医体质分布显示，前四位偏颇体质依次为痰湿质（19.9%）、气郁质（15.0%）、气虚质（12.0%）、血瘀质（10.0%）。
结论： 性别和年龄显著影响肺结节特征，部分实性结节更常见于大结节，提示需加强此类结节的恶性风险评估。中医体质的集中分布情况，更加印证其气郁痰凝的核心病机。本研究为健康人群肺结节管理提供了基线数据，并且与中医理论相联系，但需进一步纳入纵向追踪及混杂因素分析以完善临床策略。
, authors=石秋月
1, 丁云东
2, *, 张晓彤
2, 王志鹏
1, 胡文蓉
2, 刘玉霞
2, 崔宴医
2, authorsList=石秋月, 丁云东, 张晓彤, 王志鹏, 胡文蓉, 刘玉霞, 崔宴医, authorCompany=null, correspAuthors=丁云东, authorNote=
石秋月（2001-），女，硕士研究生，住院医师，研究方向：中医肺病方向。
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* 丁云东（1977 -），男，硕士，主任医师，硕士研究生导师，研究方向：中医肺病方向。
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