中医药学报

自拟调营饮加减联合隔药灸对晚期胃癌化疗后骨髓抑制贫血患者的影响

PDF下载

高敏 ¹ , 刘青 ¹ , 马盼 ²^,^*

中医药学报 | 临床研究 2026,54(7): 109-115

收起

中医药学报 |临床研究 2026 , 54 (7) : 109 -115

自拟调营饮加减联合隔药灸对晚期胃癌化疗后骨髓抑制贫血患者的影响

全屏

[Author(id=1307269501590991615, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269501649711873, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, authorId=1307269501590991615, language=EN, stringName=Min GAO, firstName=Min, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Department of Oncology, Hengshui Hospital of Traditional Chinese Medicine, Hengshui 053099, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269501716820738, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, authorId=1307269501590991615, language=CN, stringName=高敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.衡水市中医医院肿瘤科，河北衡水 053099, bio={"content":"

高敏（1992-），女，主治医师，从事肿瘤疾病的临床研究。

"}, bioImg=null, bioContent=

高敏（1992-），女，主治医师，从事肿瘤疾病的临床研究。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269501423219448, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, xref=1., ext=[AuthorCompanyExt(id=1307269501431608057, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, companyId=1307269501423219448, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Department of Oncology, Hengshui Hospital of Traditional Chinese Medicine, Hengshui 053099, China), AuthorCompanyExt(id=1307269501439996666, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, companyId=1307269501423219448, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.衡水市中医医院肿瘤科，河北衡水 053099)])]), Author(id=1307269501775540996, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269501838455558, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, authorId=1307269501775540996, language=EN, stringName=Qing LIU, firstName=Qing, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Department of Oncology, Hengshui Hospital of Traditional Chinese Medicine, Hengshui 053099, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269501901370119, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, authorId=1307269501775540996, language=CN, stringName=刘青, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.衡水市中医医院肿瘤科，河北衡水 053099, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269501423219448, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, xref=1., ext=[AuthorCompanyExt(id=1307269501431608057, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, companyId=1307269501423219448, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Department of Oncology, Hengshui Hospital of Traditional Chinese Medicine, Hengshui 053099, China), AuthorCompanyExt(id=1307269501439996666, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, companyId=1307269501423219448, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.衡水市中医医院肿瘤科，河北衡水 053099)])]), Author(id=1307269501985256201, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1307269502073336587, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, authorId=1307269501985256201, language=EN, stringName=Pan MA, firstName=Pan, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=²^,^*, address=^2.Second Department of Oncology Department of Oncology, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang 050033, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269502136251148, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, authorId=1307269501985256201, language=CN, stringName=马盼, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=²^,^*, address=^2.河北省中医院肿瘤二科，河北石家庄 050033, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269501502911227, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, xref=2., ext=[AuthorCompanyExt(id=1307269501507105532, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, companyId=1307269501502911227, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Second Department of Oncology Department of Oncology, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang 050033, China), AuthorCompanyExt(id=1307269501515494141, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269500655661813, companyId=1307269501502911227, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.河北省中医院肿瘤二科，河北石家庄 050033)])])]

高敏¹, 刘青¹, 马盼²^,^*

作者信息

^1.衡水市中医医院肿瘤科，河北衡水 053099

^2.河北省中医院肿瘤二科，河北石家庄 050033

通讯作者:

^* 马盼（1991 -），女，硕士，主治医师，主要从事恶性肿瘤的中西医结合治疗。

作者简介:

高敏（1992-），女，主治医师，从事肿瘤疾病的临床研究。

Effects of Self-Formulated Modified Tiaoying Deconction Combined with Herbal-partitioned Moxibution on Advanced Gastric Cancer Patients with Chemotherapy-induced Myelosuppressive Anemia

Min GAO¹, Qing LIU¹, Pan MA²^,^*

Affiliations

^1.Department of Oncology, Hengshui Hospital of Traditional Chinese Medicine, Hengshui 053099, China

^2.Second Department of Oncology Department of Oncology, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang 050033, China

出版时间: 2026-07-20 doi: 10.19664/j.cnki.1002-2392.260150

文章导航

摘要

收起

目的：

观察自拟调营饮联合隔药灸对晚期胃癌化疗后骨髓抑制贫血患者免疫调节、血小板参数和外周血内皮祖细胞数量及功能的影响。

方法：

选取2022年4月—2024年4月就诊于衡水市中医医院的晚期胃癌化疗后骨髓抑制贫血患者104例，采用随机数字表法分为对照组52例（脱落3例，最终纳入49例），治疗组52例（脱落4例，最终纳入48例），对照组给予西医常规治疗，治疗组在西医常规治疗基础上给予隔药灸联合自拟调营饮，疗程结束后比较两组临床疗效，治疗前后观察中医证候各项评分，通过癌症患者生命质量测定量表（FACT-G）评价生活质量，检测患者中性粒细胞、血红蛋白、白细胞计数、血小板计数水平，检测外周血中循环内皮祖细胞数量和迁移至底层的内皮细胞数量，检测患者活性氧（ROS）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、Notch2、Numb1、CD4⁺、CD8^+、CD16⁺ CD56⁺水平。比较两组患者1年复发率和1年生存率。

结果：

治疗组患者总有效率为95.83% （46/48），对照组总有效率为79.59% （39/49），治疗组总有效率高于对照组（P < 0.05）；治疗组中医证候各项评分低于对照组（P < 0.05），治疗组FACT-G评分高于对照组（P < 0.05）；治疗组中性粒细胞、血红蛋白、白细胞计数、血小板计数水平高于对照组（P < 0.05）；治疗组外周血循环内皮祖细胞数量、迁移能力低于对照组（P < 0.05）；治疗组患者CD4⁺、CD16⁺ CD56⁺水平均高于对照组（P < 0.05），治疗组CD8⁺水平低于对照组（P < 0.05）；治疗组患者ROS、GM-CSF、Notch2表达水平低于对照组（P < 0.05），治疗组患者Numb1表达水平高于对照组（P < 0.05）。治疗组1年复发率为31.25% （15/48）低于对照组的53.06% （26/49），差异有统计学意义（P < 0.05），治疗组1年生存率97.92% （47/48）高于对照组的81.63% （40/49），差异有统计学意义（P < 0.01）。

结论：

自拟调营饮联合隔药灸治疗晚期胃癌化疗后骨髓抑制贫血患者，可减少氧化应激反应，调节患者免疫功能及血小板参数，改善外周血内皮祖细胞数量及功能，缓解病情，提升临床疗效及生活质量。

关键词

自拟调营饮 / 隔药灸 / 晚期胃癌 / 化疗后骨髓抑制贫血 / 氧化应激反应 / 免疫功能 / 外周血内皮祖细胞

Abstract

收起

Objective:

To observe the effects of self-formulated modified Tiaoying Decoction with modifications combined with herb-partitioned moxibustion on immune regulation, platelet parameters and the number and function of endothelial progenitor cells in peripheral blood of patients with myeloid suppression anemia after chemotherapy for advanced gastric cancer.

Methods:

We selected 104 patients with myelosuppressive anemia after chemotherapy for advanced gastric cancer who were treated in Hengshui Hospital of Traditional Chinese Medicine from April 2022 to April 2024. They were divided into a control group of 52 cases (3 cases dropped out, and finally 49 cases were included) and a treatment group of 52 cases (4 cases dropped out, and finally 48 cases were included) by the random number table method. Both groups were given routine Western medicine treatment simultaneously. The treatment group was given herb-partitioned moxibustion combined with self-formulated modified Tiaoying Decoction with modifications on the basis of routine Western medicine treatment. After the treatment course, the clinical efficacy of the two groups was compared. Before and after treatment, the scores of various traditional Chinese medicine syndromes were observed. The quality of life was evaluated by the Functional Assessment of Cancer Therapy-General (FACT-G). The levels of neutrophils, hemoglobin, white blood cell count and platelet count of patients were detected. The number and migration ability of circulating endothelial progenitor cells in peripheral blood were detected. The levels of reactive oxygen species (ROS), granulocyte-macrophage colony-stimulating factor (GM-CSF), Notch2, Numb1, CD4⁺ cells, CD8⁺cells and CD16⁺ CD56⁺ cells in patients were detected. The 1-year recurrence rate and 1-year survival rate of the two groups of patients were compared.

Results:

The treatment group's total effective rate was 95.83%. The control group's total effective rate was 79.59%. The treatment group's total effective rate was higher than the control group (P < 0.05). The treatment group's scores of TCM syndrome was lower than control group (P < 0.05). The treatment group's FACT-G scores was higher than the control group (P <0.05). The treatment group's neutrophil, hemoglobin, white blood cell count and platelet count in treatment group levels were higher than control group (P < 0.05). The treatment group's number and migration ability of peripheral blood circulating endothelial progenitor cells were lower than control group (P <0.05). The treatment group's CD4⁺ cells and CD16⁺ CD56⁺cells levels were higher than control group (P < 0.05). The treatment group's expression of CD8⁺ cells was lower than control group (P < 0.05). The treatment group's ROS, GM-CSF and Notch2 expression levels were lower than control group (P < 0.05). The treatment group's expression level of Numb1 was higher than that in the control group (P < 0.05). The 1-year recurrence rate of the treatment group was 31.25%, which was lower than 53.06% of the control group (P < 0.05), and the 1-year survival rate of the treatment group was 97.92%, which was higher than 81.63% of the control group (P < 0.05).

Conclusion:

Self-formulated modified Tiaoying Decoction with modifications combined with herb-partitioned moxibustion can reduce the oxidative stress response, regulate the immune function and platelet parameters of patients, improve the number and function of peripheral blood endothelial progenitor cells, alleviate the disease, and improve the clinical efficacy and quality of life in the treatment of patients with advanced gastric cancer after chemotherapy.

Key words

Self-formulated modified Tiaoying Decoction / Herb-partitioned moxibustion / Advanced gastric cancer / Chemotherapy-induced bone marrow suppression anemia / Oxidative stress response / Immune function / Peripheral blood endothelial progenitor cells

引用本文

高敏, 刘青, 马盼. 自拟调营饮加减联合隔药灸对晚期胃癌化疗后骨髓抑制贫血患者的影响. 中医药学报, 2026 , 54 (7) : 109 -115 . DOI: 10.19664/j.cnki.1002-2392.260150

Min GAO, Qing LIU, Pan MA. Effects of Self-Formulated Modified Tiaoying Deconction Combined with Herbal-partitioned Moxibution on Advanced Gastric Cancer Patients with Chemotherapy-induced Myelosuppressive Anemia[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (7) : 109 -115 . DOI: 10.19664/j.cnki.1002-2392.260150

基金

收起

河北省中医药管理局科研计划项目(2022332)

参考文献

收起

文献

收起

参考文献引证文献

排序方式：

2026年第54卷第7期

PDF下载

引用本文

BibTeX

文章信息

doi: 10.19664/j.cnki.1002-2392.260150

接收时间：2025-06-20
首发时间：2026-09-17
出版时间：2026-07-20

补充材料

相关文章

文章信息

作者

出版历史

收稿日期：2025-06-20
修回日期：2025-12-01

基金

河北省中医药管理局科研计划项目(2022332)

作者信息

^1.衡水市中医医院肿瘤科，河北衡水 053099

^2.河北省中医院肿瘤二科，河北石家庄 050033

通讯作者:

^* 马盼（1991 -），女，硕士，主治医师，主要从事恶性肿瘤的中西医结合治疗。

参考文献

分享链接

https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260150

分享至

全文二维码

扫描看全文

引用本文

BibTeX

本文的引用情况

2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT