Article(id=1307269499753877619, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269479684133809, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260147, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1733673600000, receivedDateStr=2024-12-09, revisedDate=1759248000000, revisedDateStr=2025-10-01, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606936633, onlineDateStr=2026-09-17, pubDate=1784476800000, pubDateStr=2026-07-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606936633, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606936633, creator=13701087609, updateTime=1789606936633, updator=13701087609, issue=Issue{id=1307269479684133809, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='7', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1784476800000', pubDateStr='2026-07-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606931849, creator='13701087609', updateTime=1789606931849, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=90, endPage=95, ext={EN=ArticleExt(id=1307269499951009908, articleId=1307269499753877619, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effect of Rhubarb Decoction Combined with Intradermal Granule on Bone Marrow Edema, Finger Microcirculation and Th17/Treg in Peripheral Blood of Rheumatoid Arthritis, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To observe the effects of Rhubarb Decoction combined with intradermal granule on bone marrow edema, finger microcirculation and Th17/Treg in peripheral blood of rheumatoid arthritis.
Methods: A total of 100 patients with rheumatoid arthritis treated in the hospital from April 2022 to February 2024 were selected and divided into control group and observation group with 50 cases in each group by random number table method. Both groups were given basic symptomatic treatment, the control group was given granular intradermal acupuncture treatment on the basis of this treatment, and the observation group was given ultrasonic introduction therapy with rhubarb decoction on the basis of the control group. After 4 weeks of continuous treatment, the clinical efficacy of the control group and the observation group were compared. TCM syndrome score and wrist bone marrow edema score were observed before and after treatment, 6-point behavior score (BRS-6) and 28-point joint disease activity score (DAS-28) were performed. The vascular resistance index, vascular index, blood flow index and blood flow index of the middle nail bed artery of the patient were detected and calculated, and the levels of Th17/Treg, tumor necrosis factor-α (TNF-α), rheumatoid factor (RF) and reactive oxygen species (ROS) were detected.
Results: The total effective rate of Rhubarb Decoction combined with intradermal acupuncture group was 98.00%, and that of Western medicine group was 82.00%. The total effective rate of Rhubarb Decoction combined with intradermal acupuncture group was higher than that of Western medicine group (P < 0.05). Joint pain, fever, joint swelling, morning stiffness, joint fever, sweating, poor joint flexion and extension, and thirst score of Rhubarb Decoction combined with intradermal acupuncture group were lower than those of Western medicine group (P < 0.05). DAS28, bone marrow edema and BRS-6 scores of Rhubarb Decoction combined with intradermal acupuncture group were lower than those of western medicine group (P < 0.05). The fingernail bed artery resistance index of Rhubarb Decoction combined with intradermal acupuncture group was lower than that of Western medicine group (P < 0.05), and the vascular index, blood flow index and blood flow index of Rhubarb Decoction combined with intradermal acupuncture group were higher than that of Western medicine group (P <0.05). The contents of Th17/Treg, TNF-α, RF and ROS in Rhubarb Decoction combined with intradermal acupuncture group were lower than those in western medicine group (P < 0.05).
Conclusion: Rhubarb Decoction combined with granular intradermal acupuncture can regulate Th17/Treg balance, inhibit inflammation and oxidative stress, reduce bone marrow edema, improve finger microcirculation, relieve pain and improve clinical efficacy in the treatment of patients with rheumatoid arthritis.
, authors=Qinlong KANG, Wen GAO, Ming LI, Ying GU, authorsList=Qinlong KANG, Wen GAO, Ming LI, Ying GU, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269500290748533, articleId=1307269499753877619, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=大黄汤超声导入联合颗粒型皮内针对类风湿关节炎骨髓水肿
、指端微循环及外周血Th17/Treg的影响, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 观察大黄汤超声导入联合颗粒型皮内针对类风湿关节炎骨髓水肿、指端微循环及外周血Th17/Treg的影响。
方法： 选择2022年4月—2024年2月绵阳市中医医院治疗的100例类风湿关节炎患者，采用随机数字表法分为对照组和观察组，每组50例，两组均给予基础对症治疗，对照组在此基础上给予颗粒型皮内针治疗，观察组在对照组治疗基础上加用大黄汤超声导入治疗，连续治疗4周后比较对照组、观察组临床疗效，治疗前后观察两组中医证候评分，对两组患者腕关节骨髓水肿进行评分，行6点行为评分法（BRS-6）、28个关节疾病活动评分（DAS-28），检测并计算患者右手中指甲床动脉血管阻力指数、血管指数、血流指数、血管血流指数，检测Th17/Treg、肿瘤坏死因子-α（TNF-α）、类风湿因子（RF）、活性氧簇（ROS）水平。观察两组不良反应情况。
结果： 观察组总有效率为98.00%（49/50），对照组总有效率为82.00%（41/50），观察组总有效率高于对照组（P < 0.05）；观察组中医证候评分较对照组低（P < 0.01）；观察组DAS28、骨髓水肿、BRS-6评分较对照组低（P < 0.01）；观察组中指甲床动脉血管阻力指数较对照组低（P < 0.01），观察组血管指数、血流指数、血管血流指数较对照组高（P < 0.01）；观察组Th17/Treg、TNF-α、RF、ROS含量较对照组低（P < 0.01）。两组不良反应比较差异无统计学意义（P > 0.05）。
结论： 大黄汤超声导入联合颗粒型皮内针治疗类风湿关节炎患者，可调节Th17/Treg平衡，抑制炎症和氧化应激反应，减少骨髓水肿，改善指端微循环，缓解疼痛，提升临床疗效且安全性高。
, authors=康勤龙, 高闻, 李明, 古英, authorsList=康勤龙, 高闻, 李明, 古英, authorCompany=null, correspAuthors=null, authorNote=
康勤龙（1991-），男，硕士，主治医师，研究方向：中西医结合治疗风湿免疫疾病。
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康勤龙（1991-），男，硕士，主治医师，研究方向：中西医结合治疗风湿免疫疾病。
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康勤龙（1991-），男，硕士，主治医师，研究方向：中西医结合治疗风湿免疫疾病。
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