Article(id=1307269491168137243, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269479684133809, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260143, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753891200000, receivedDateStr=2025-07-31, revisedDate=1774454400000, revisedDateStr=2026-03-26, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606934587, onlineDateStr=2026-09-17, pubDate=1784476800000, pubDateStr=2026-07-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606934587, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606934587, creator=13701087609, updateTime=1789606934587, updator=13701087609, issue=Issue{id=1307269479684133809, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='7', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1784476800000', pubDateStr='2026-07-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606931849, creator='13701087609', updateTime=1789606931849, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=67, endPage=71, ext={EN=ArticleExt(id=1307269491331715100, articleId=1307269491168137243, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effect of Modified Shaoyao Decoction Combined with Acupoint Catgut Embedding on the Endoscopic Severity Index of Ulcerative Colitis, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the clinical effect of modified Shaoyao Decoction combined with acupoint embedding in the treatment of patients with ulcerative colitis (UC).
Methods: A total of 120 patients with internal damp-heat type UC who visited the Department of Anorectal Diseases of the Second Affiliated Hospital of Hunan University of Chinese Medicine from April 2023 to April 2025 were prospectively selected. They were grouped using the random number table method and assigned by independent researchers. Although the intervention measures limited the blinding of patients, the assessment of endoscopic outcomes strictly followed the blinding principle. The treatment was carried out by endoscopists who were unaware of the grouping situation. The control group (with 0 cases dropped out and 60 cases ultimately included) was given Western medicine and acupoint embedding treatment, while the combined group (with 0 cases dropped out and 60 cases ultimately included) was treated with modified Shaoyao Decoction on this basis. The treatment courses are all 6 weeks. The changes of TCM symptoms scores and ulcerative colitis endoscopic index of severity (UCEIS) before and after treatment were compared between groups. The expression levels of Th17/Treg cell balance-related indicators [IL-22, IL-21, IL-10, transforming growth factor-β (TGF-β)] were detected, and the clinical efficacy and safety of the two groups before and after treatment were evaluated.
Results: After 6 weeks of treatment, the total clinical effective rate in the combined group was 95.00% (57/60), which was much higher than 83.33% (50/60) in the control group (χ2 = 4.227, P < 0.05). The UCEIS scores, TCM symptoms scores and levels of IL-22 and IL-21 in the two groups after treatment were significantly reduced compared with those before treatment (P < 0.05), and the above scores and levels were lower in the combined group than those in the control group (P <0.05). The levels of IL-10 and TGF-β were significantly enhanced in the two groups compared to before treatment (P < 0.05), and the combined group had higher levels (P <0.05). There were no obvious adverse reactions in the two groups after treatment.
Conclusion: The modified Shaoyao Decoction combined with acupoint embedding thread can effectively improve the symptoms and therapeutic effect of UC patients, and can reduce the UCEIS scores. Additionally, it can also reduce the inflammatory response by regulating the expression levels of Th17/Treg cell balance-related indicators, with good safety.
, authors=Jianzheng ZHAO, Zhenquan WANG, Jing LI, Qing LU, Ziyu LI, You XIAO
*, authorsList=Jianzheng ZHAO, Zhenquan WANG, Jing LI, Qing LU, Ziyu LI, You XIAO, authorCompany=null, correspAuthors=You XIAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269491663065117, articleId=1307269491168137243, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=芍药汤加味结合穴位埋线治疗溃疡性结肠炎(湿热内蕴型)临床研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探讨溃疡性结肠炎（UC）患者应用芍药汤加味结合穴位埋线治疗的临床效果。
方法： 前瞻性选取2023年4月—2025年4月湖南中医药大学第二附属医院肛肠科就诊的120例湿热内蕴型UC患者，使用随机数字表法进行分组，由独立研究者执行分配，尽管干预措施限制了对患者设盲，但内镜结局的评估严格遵循了盲法原则，由不知分组情况的内镜医师完成，对照组（脱落0例，最终纳入60例）给予西药+穴位埋线治疗，联合组（脱落0例，最终纳入60例）在此基础上联合芍药汤加味治疗。疗程均为6周。比较两组治疗前后中医症状评分和溃疡性结肠炎内镜下严重程度指数（UCEIS）评分的变化，检测Th17/Treg细胞平衡相关指标［IL-22、IL-21、IL-10、转化生长因子-β（TGF-β）］表达水平，并评价治疗前后两组的临床疗效和安全性。
结果： 在治疗6周后，联合组临床总有效率为95.00% （57/60）高于对照组的83.33% （50/60），差异有统计学意义（P < 0.05）。治疗后，两组患者的UCEIS评分、中医症状评分、IL-22、IL-21均较治疗前明显降低（P < 0.05），且联合组低于对照组（P < 0.05）；两组的IL-10、TGF-β均较治疗前明显提高（P < 0.05），且联合组高于对照组（P < 0.05）。两组患者经治疗后未见明显不良反应。
结论： 芍药汤加味联合穴位埋线可有效改善UC患者的症状及疗效，并能降低UCEIS评分，还能通过调控Th17/Treg细胞平衡相关指标的表达水平，减轻炎症反应，且具备良好的安全性。
, authors=赵建政, 王真权, 李晶, 陆晴, 李梓瑜, 肖佑
*, authorsList=赵建政, 王真权, 李晶, 陆晴, 李梓瑜, 肖佑, authorCompany=null, correspAuthors=肖佑, authorNote=
赵建政（1995-），男，硕士，主治医师，主要从事肛门结直肠外科研究。
, correspAuthorsNote=
* 肖佑（1985 -），男，硕士，副主任医师，主要从事肛门结直肠外科研究。
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赵建政（1995-），男，硕士，主治医师，主要从事肛门结直肠外科研究。
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赵建政（1995-），男，硕士，主治医师，主要从事肛门结直肠外科研究。
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