Article(id=1307269480451699257, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269479684133809, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260133, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1743350400000, receivedDateStr=2025-03-31, revisedDate=1764604800000, revisedDateStr=2025-12-02, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606932031, onlineDateStr=2026-09-17, pubDate=1784476800000, pubDateStr=2026-07-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606932031, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606932031, creator=13701087609, updateTime=1789606932031, updator=13701087609, issue=Issue{id=1307269479684133809, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='7', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1784476800000', pubDateStr='2026-07-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606931849, creator='13701087609', updateTime=1789606931849, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=5, endPage=11, ext={EN=ArticleExt(id=1307269480611082810, articleId=1307269480451699257, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Mechanism of Icaritin in Improving Myocardial Injury in Septic Mice via the AMPK/NLRP3 Pathway, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To explore the intervention mechanism of icaritin (ICT) on myocardial injury in sepsis.

Methods:

Mice were divided into control group, model group, AMPK activator (MET) group, icaritin (ICT) group and icaritin+AMPK inhibitor compound C (ICT+CC) group, with 12 mice in each group. Except for the control group, the other mice were intraperitoneally injected with LPS. ICT group was intraperitoneally injected with ICT 30 minutes before modeling, and ICT+CC group was injected with AMPK inhibitor Compound C at the same time. After 24 hours of modeling, cardiac function, myocardial pathological changes, AMPK pathway and pyroptosis-related protein expression, serum inflammatory factors and myocardial injury markers were detected.

Results:

The intervention of ICT and AMPK activators significantly improved the survival rate of mice, increased cardiac LVEF and LVFS, and decreased LVIDD and LVIDS. Tissue damage was reduced and inflammatory cell infiltration was reduced. The levels of serum TNF-α, IL-1β, IL-18, CK-MB and LDH were decreased. The ratio of p-AMPK/AMPK was increased, and the expression of NLRP3, ASC, Cleaved Caspase-1, GSDMD-NT and Cleaved IL-1β was decreased (P < 0.05). Compound C could reverse the improvement effect of ICT on myocardial injury, increase inflammation index and pyroptosis protein expression (P <0.05).

Conclusion:

ICT can improve myocardial injury and inflammatory response in sepsis mice, and its mechanism may be related to the activation of AMPK to inhibit pyroptosis mediated by NLRP3 signaling pathway.

, authors=Fengxiao SUN1, Qingyan WANG1, Jing ZHANG1, Bo DONG2, *, authorsList=Fengxiao SUN, Qingyan WANG, Jing ZHANG, Bo DONG, authorCompany=null, correspAuthors=Bo DONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269481080844859, articleId=1307269480451699257, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=淫羊藿素通过AMPK/NLRP3通路改善脓毒症小鼠心肌损伤的机制研究, columnId=1303760926633652690, journalTitle=中医药学报, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的:

探究淫羊藿素(ICT)对脓毒症心肌损伤的干预机制。

方法:

将小鼠随机分为对照组、模型组、AMPK激活剂组(MET组)、淫羊藿素组(ICT组)、淫羊藿素组+AMPK抑制剂化合物C组(ICT+CC组),每组12只。除对照组外,其余小鼠腹腔注射LPS造模。ICT组造模前30 min腹腔注射ICT,ICT+CC组同时注射AMPK抑制剂Compound C。造模24 h后,检测小鼠心功能、心肌病理变化、AMPK通路和焦亡相关蛋白表达及血清炎症因子和心肌损伤标志物浓度。

结果:

ICT和AMPK激活剂的干预明显提高了脓毒症小鼠生存率,心脏LVEF、LVFS值升高(P < 0.05),LVIDD、LVIDS降低(P < 0.05);心肌组织损伤减轻,炎症细胞浸润减少;血清TNF-α、IL-1β、IL-18、CK-MB以及LDH水平降低(P < 0.05);蛋白p-AMPK/AMPK比值升高(P < 0.05),NLRP3、ASC、Cleaved Caspase-1、GSDMD-NT、Cleaved IL-1β表达减少(P < 0.05)。而Compound C可逆转ICT对心肌损伤的改善效果,炎症指标升高,焦亡蛋白表达增加。

结论:

ICT可改善小鼠脓毒症心肌损伤和炎症反应,其作用机制可能与激活AMPK抑制NLRP3信号通路介导的细胞焦亡有关。

, authors=孙凤霄1, 王磬妍1, 张敬1, 董波2, *, authorsList=孙凤霄, 王磬妍, 张敬, 董波, authorCompany=null, correspAuthors=董波, authorNote=

孙凤霄(1999-),女,硕士研究生,从事中西医结合心系疾病相关研究。

, correspAuthorsNote=
* 董波(1964 -),男,博士,教授,从事中西医结合心系疾病相关研究。
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=wynH/ZP9n6rewxBLSQJORg==, magXml=QoFgZkCBOkfgpcojbY5c6w==, pdfUrl=null, pdf=9MM05xrVHj5SZA6DDS1Npg==, pdfFileSize=7289944, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=kHUpkC0o6sfG5w1sMDCUYA==, mapNumber=null, fund=null)}, authors=[Author(id=1307269481445749315, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269481521246789, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269481445749315, language=EN, stringName=Fengxiao SUN, firstName=Fengxiao, middleName=null, lastName=SUN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269481600938566, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269481445749315, language=CN, stringName=孙凤霄, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.山东中医药大学,山东 济南 250013, bio={"content":"

孙凤霄(1999-),女,硕士研究生,从事中西医结合心系疾病相关研究。

"}, bioImg=null, bioContent=

孙凤霄(1999-),女,硕士研究生,从事中西医结合心系疾病相关研究。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269481294754364, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, xref=1., ext=[AuthorCompanyExt(id=1307269481298948669, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China), AuthorCompanyExt(id=1307269481307337278, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.山东中医药大学,山东 济南 250013)])]), Author(id=1307269481668047432, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269481819042378, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269481668047432, language=EN, stringName=Qingyan WANG, firstName=Qingyan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269481965843019, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269481668047432, language=CN, stringName=王磬妍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.山东中医药大学,山东 济南 250013, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269481294754364, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, xref=1., ext=[AuthorCompanyExt(id=1307269481298948669, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China), AuthorCompanyExt(id=1307269481307337278, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.山东中医药大学,山东 济南 250013)])]), Author(id=1307269482070700623, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269482167169619, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269482070700623, language=EN, stringName=Jing ZHANG, firstName=Jing, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269482242667092, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269482070700623, language=CN, stringName=张敬, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.山东中医药大学,山东 济南 250013, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269481294754364, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, xref=1., ext=[AuthorCompanyExt(id=1307269481298948669, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China), AuthorCompanyExt(id=1307269481307337278, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.山东中医药大学,山东 济南 250013)])]), Author(id=1307269482481742422, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1307269484121715288, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269482481742422, language=EN, stringName=Bo DONG, firstName=Bo, middleName=null, lastName=DONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, *, address=2.Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269484205601369, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269482481742422, language=CN, stringName=董波, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, *, address=2.山东第一医科大学附属省立医院,山东 济南 250021, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269481370251839, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, xref=2., ext=[AuthorCompanyExt(id=1307269481378640448, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481370251839, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China), AuthorCompanyExt(id=1307269481387029057, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481370251839, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.山东第一医科大学附属省立医院,山东 济南 250021)])])], keywords=[Keyword(id=1307269484289487450, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, language=EN, orderNo=1, keyword=Icaritin), Keyword(id=1307269484360790619, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, language=EN, orderNo=2, keyword=Sepsis), Keyword(id=1307269484444676700, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, language=EN, orderNo=3, keyword=Myocardial injury), Keyword(id=1307269484515979869, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, language=EN, orderNo=4, keyword=Pyroptosis), Keyword(id=1307269484599865950, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, language=EN, orderNo=5, keyword=AMPK/NLRP3 pathway), Keyword(id=1307269484666974815, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, language=CN, orderNo=1, keyword=淫羊藿素), Keyword(id=1307269484734083680, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, language=CN, orderNo=2, keyword=脓毒症), Keyword(id=1307269484822164065, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, language=CN, orderNo=3, keyword=心肌损伤), Keyword(id=1307269484889272930, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, language=CN, orderNo=4, keyword=细胞焦亡), Keyword(id=1307269484973159011, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, language=CN, orderNo=5, keyword=AMPK/NLRP3通路)], refs=null, funds=[Fund(id=1307269485086405220, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, awardId=82070382, language=CN, fundingSource=国家自然科学基金面上项目(82070382), fundOrder=null, country=null), Fund(id=1307269485157708389, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, awardId=ts20190979, language=CN, fundingSource=山东省泰山学者基金项目(ts20190979), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1307269481294754364, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, xref=1., ext=[AuthorCompanyExt(id=1307269481298948669, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China), AuthorCompanyExt(id=1307269481307337278, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.山东中医药大学,山东 济南 250013)]), AuthorCompany(id=1307269481370251839, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, xref=2., ext=[AuthorCompanyExt(id=1307269481378640448, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481370251839, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China), AuthorCompanyExt(id=1307269481387029057, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481370251839, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.山东第一医科大学附属省立医院,山东 济南 250021)])], figs=null, attaches=null, journal=Journal(id=1302309566618370119, delFlag=0, nameCn=中医药学报, nameEn=Acta Chinese Medicine and Pharmacology, nameHistory1=null, nameHistory2=null, issn=1002-2392, eissn=null, cn=23-1193/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=waDramTH0+y3s1K97qNETA==, journalPrice=null, startedYear=null, abbrevIsoEn=Acta Chinese Medicine and Pharmacology, journalRemark=null, publicationField=null, createdTime=1788424396424, updatedTime=1788949300331, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=waDramTH0+y3s1K97qNETA==, picEn=VlAd9bvB1BDYZKhr1kPAgA==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511173278326962, language=CN, name=中医药学报, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949300355, updatedTime=1788949300355, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://zyyxb.hljucm.net/ch/author/login.aspx, submissionEditorUrl=http://zyyxb.hljucm.net/ch/login.aspx, submissionReviewUrl=http://zyyxb.hljucm.net/ch/auditor/login.aspx, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511173332852915, language=EN, name=Acta Chinese Medicine and Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949300368, updatedTime=1788949300368, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://zyyxb.hljucm.net/ch/author/login.aspx, submissionEditorUrl=http://zyyxb.hljucm.net/ch/login.aspx, submissionReviewUrl=http://zyyxb.hljucm.net/ch/auditor/login.aspx, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302318977290174537, websiteList=[Website(id=1302319176404717747, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302318977290174537, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zyyxb/CN, language=CN, createTime=1788426687575, createBy=18614031015, updateTime=1788427253465, updateBy=18614031015, name=中医药学报-中文, tplId=1146099689490845704, title=中医药学报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302323257894527683, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=articleTextType, value=kx, createTime=1788427660678, updateTime=1788427660678, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257873556160, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=banner, value=null, createTime=1788427660673, updateTime=1788427660673, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257915499206, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=grayFlag, value=0, createTime=1788427660683, updateTime=1788427660683, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257865167551, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=logo, value=https://castjournals.cast.org.cn/joweb/zyyxb/CN/file/pic?fileId=YNbTWTD2kN1YqdKssxyBxQ==, createTime=1788427660671, updateTime=1788427660671, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257923887816, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=minRunFlag, value=0, createTime=1788427660685, updateTime=1788427660685, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257890333378, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zyyxb/CN/file/pic, createTime=1788427660677, updateTime=1788427660677, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257919693511, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=silenceFlag, value=0, createTime=1788427660684, updateTime=1788427660684, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257881944769, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427660675, updateTime=1788427660675, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257902916292, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=themeColor, value=null, createTime=1788427660680, updateTime=1788427660680, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257907110597, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=themeStyle, value=null, createTime=1788427660681, updateTime=1788427660681, creator=18614031015, updator=18614031015)]), Website(id=1302319176459243701, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302318977290174537, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zyyxb/EN, language=EN, createTime=1788426687588, createBy=18614031015, updateTime=1788427242219, updateBy=18614031015, name=中医药学报-英文, tplId=1146101810881728533, title=Acta Chinese Medicine and Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302323289888678612, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=articleTextType, value=kx, createTime=1788427668306, updateTime=1788427668306, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289867707089, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=banner, value=null, createTime=1788427668301, updateTime=1788427668301, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289909650135, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=grayFlag, value=0, createTime=1788427668311, updateTime=1788427668311, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289859318480, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=logo, value=https://castjournals.cast.org.cn/joweb/zyyxb/EN/file/pic?fileId=YNbTWTD2kN1YqdKssxyBxQ==, createTime=1788427668299, updateTime=1788427668299, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289926427353, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=minRunFlag, value=0, createTime=1788427668315, updateTime=1788427668315, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289880290003, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zyyxb/EN/file/pic, createTime=1788427668304, updateTime=1788427668304, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289918038744, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=silenceFlag, value=0, createTime=1788427668313, updateTime=1788427668313, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289871901394, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427668302, updateTime=1788427668302, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289892872917, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=themeColor, value=null, createTime=1788427668307, updateTime=1788427668307, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289901261526, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=themeStyle, value=null, createTime=1788427668309, updateTime=1788427668309, creator=18614031015, updator=18614031015)])], journalTitle=中医药学报, weixinUrl=null, journalUrl=http://zyyxb.hljucm.net/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Acta Chinese Medicine and Pharmacology, journalPhotoCn=waDramTH0+y3s1K97qNETA==, journalPhotoEn=VlAd9bvB1BDYZKhr1kPAgA==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260133, detailUrlEn=https://castjournals.cast.org.cn/joweb/zyyxb/EN/10.19664/j.cnki.1002-2392.260133, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zyyxb/CN/PDF/10.19664/j.cnki.1002-2392.260133, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zyyxb/EN/PDF/10.19664/j.cnki.1002-2392.260133, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1784476800000, fullTextJson=null, articleText=null, reference=null)
收藏切换
淫羊藿素通过AMPK/NLRP3通路改善脓毒症小鼠心肌损伤的机制研究
收藏切换
PDF下载
孙凤霄 1 , 王磬妍 1 , 张敬 1 , 董波 2, *
中医药学报 | 实验研究 2026,54(7): 5-11
收起
收藏切换
中医药学报 |实验研究 2026 , 54 (7) : 5 -11
淫羊藿素通过AMPK/NLRP3通路改善脓毒症小鼠心肌损伤的机制研究
全屏
[Author(id=1307269481445749315, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269481521246789, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269481445749315, language=EN, stringName=Fengxiao SUN, firstName=Fengxiao, middleName=null, lastName=SUN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269481600938566, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269481445749315, language=CN, stringName=孙凤霄, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.山东中医药大学,山东 济南 250013, bio={"content":"

孙凤霄(1999-),女,硕士研究生,从事中西医结合心系疾病相关研究。

"}, bioImg=null, bioContent=

孙凤霄(1999-),女,硕士研究生,从事中西医结合心系疾病相关研究。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269481294754364, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, xref=1., ext=[AuthorCompanyExt(id=1307269481298948669, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China), AuthorCompanyExt(id=1307269481307337278, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.山东中医药大学,山东 济南 250013)])]), Author(id=1307269481668047432, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269481819042378, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269481668047432, language=EN, stringName=Qingyan WANG, firstName=Qingyan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269481965843019, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269481668047432, language=CN, stringName=王磬妍, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.山东中医药大学,山东 济南 250013, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269481294754364, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, xref=1., ext=[AuthorCompanyExt(id=1307269481298948669, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China), AuthorCompanyExt(id=1307269481307337278, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.山东中医药大学,山东 济南 250013)])]), Author(id=1307269482070700623, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269482167169619, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269482070700623, language=EN, stringName=Jing ZHANG, firstName=Jing, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269482242667092, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269482070700623, language=CN, stringName=张敬, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.山东中医药大学,山东 济南 250013, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269481294754364, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, xref=1., ext=[AuthorCompanyExt(id=1307269481298948669, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China), AuthorCompanyExt(id=1307269481307337278, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481294754364, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.山东中医药大学,山东 济南 250013)])]), Author(id=1307269482481742422, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1307269484121715288, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269482481742422, language=EN, stringName=Bo DONG, firstName=Bo, middleName=null, lastName=DONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, *, address=2.Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269484205601369, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, authorId=1307269482481742422, language=CN, stringName=董波, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, *, address=2.山东第一医科大学附属省立医院,山东 济南 250021, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269481370251839, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, xref=2., ext=[AuthorCompanyExt(id=1307269481378640448, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481370251839, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China), AuthorCompanyExt(id=1307269481387029057, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480451699257, companyId=1307269481370251839, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.山东第一医科大学附属省立医院,山东 济南 250021)])])]
孙凤霄1, 王磬妍1, 张敬1, 董波2, *
作者信息
  • 1.山东中医药大学,山东 济南 250013
  • 2.山东第一医科大学附属省立医院,山东 济南 250021
通讯作者:
* 董波(1964 -),男,博士,教授,从事中西医结合心系疾病相关研究。
作者简介:

孙凤霄(1999-),女,硕士研究生,从事中西医结合心系疾病相关研究。

Mechanism of Icaritin in Improving Myocardial Injury in Septic Mice via the AMPK/NLRP3 Pathway
Fengxiao SUN1, Qingyan WANG1, Jing ZHANG1, Bo DONG2, *
Affiliations
  • 1.Shandong University of Traditional Chinese Medicine, Jinan 250013, China
  • 2.Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
出版时间: 2026-07-20 doi: 10.19664/j.cnki.1002-2392.260133
文章导航
收藏切换
目的:

探究淫羊藿素(ICT)对脓毒症心肌损伤的干预机制。

方法:

将小鼠随机分为对照组、模型组、AMPK激活剂组(MET组)、淫羊藿素组(ICT组)、淫羊藿素组+AMPK抑制剂化合物C组(ICT+CC组),每组12只。除对照组外,其余小鼠腹腔注射LPS造模。ICT组造模前30 min腹腔注射ICT,ICT+CC组同时注射AMPK抑制剂Compound C。造模24 h后,检测小鼠心功能、心肌病理变化、AMPK通路和焦亡相关蛋白表达及血清炎症因子和心肌损伤标志物浓度。

结果:

ICT和AMPK激活剂的干预明显提高了脓毒症小鼠生存率,心脏LVEF、LVFS值升高(P < 0.05),LVIDD、LVIDS降低(P < 0.05);心肌组织损伤减轻,炎症细胞浸润减少;血清TNF-α、IL-1β、IL-18、CK-MB以及LDH水平降低(P < 0.05);蛋白p-AMPK/AMPK比值升高(P < 0.05),NLRP3、ASC、Cleaved Caspase-1、GSDMD-NT、Cleaved IL-1β表达减少(P < 0.05)。而Compound C可逆转ICT对心肌损伤的改善效果,炎症指标升高,焦亡蛋白表达增加。

结论:

ICT可改善小鼠脓毒症心肌损伤和炎症反应,其作用机制可能与激活AMPK抑制NLRP3信号通路介导的细胞焦亡有关。

淫羊藿素  /  脓毒症  /  心肌损伤  /  细胞焦亡  /  AMPK/NLRP3通路
Objective:

To explore the intervention mechanism of icaritin (ICT) on myocardial injury in sepsis.

Methods:

Mice were divided into control group, model group, AMPK activator (MET) group, icaritin (ICT) group and icaritin+AMPK inhibitor compound C (ICT+CC) group, with 12 mice in each group. Except for the control group, the other mice were intraperitoneally injected with LPS. ICT group was intraperitoneally injected with ICT 30 minutes before modeling, and ICT+CC group was injected with AMPK inhibitor Compound C at the same time. After 24 hours of modeling, cardiac function, myocardial pathological changes, AMPK pathway and pyroptosis-related protein expression, serum inflammatory factors and myocardial injury markers were detected.

Results:

The intervention of ICT and AMPK activators significantly improved the survival rate of mice, increased cardiac LVEF and LVFS, and decreased LVIDD and LVIDS. Tissue damage was reduced and inflammatory cell infiltration was reduced. The levels of serum TNF-α, IL-1β, IL-18, CK-MB and LDH were decreased. The ratio of p-AMPK/AMPK was increased, and the expression of NLRP3, ASC, Cleaved Caspase-1, GSDMD-NT and Cleaved IL-1β was decreased (P < 0.05). Compound C could reverse the improvement effect of ICT on myocardial injury, increase inflammation index and pyroptosis protein expression (P <0.05).

Conclusion:

ICT can improve myocardial injury and inflammatory response in sepsis mice, and its mechanism may be related to the activation of AMPK to inhibit pyroptosis mediated by NLRP3 signaling pathway.

Icaritin  /  Sepsis  /  Myocardial injury  /  Pyroptosis  /  AMPK/NLRP3 pathway
孙凤霄, 王磬妍, 张敬, 董波. 淫羊藿素通过AMPK/NLRP3通路改善脓毒症小鼠心肌损伤的机制研究. 中医药学报, 2026 , 54 (7) : 5 -11 . DOI: 10.19664/j.cnki.1002-2392.260133
Fengxiao SUN, Qingyan WANG, Jing ZHANG, Bo DONG. Mechanism of Icaritin in Improving Myocardial Injury in Septic Mice via the AMPK/NLRP3 Pathway[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (7) : 5 -11 . DOI: 10.19664/j.cnki.1002-2392.260133
  • 国家自然科学基金面上项目(82070382)
  • 山东省泰山学者基金项目(ts20190979)
参考文献 引证文献
排序方式:
2026年第54卷第7期
PDF下载
6
1
引用本文
BibTeX
文章信息
doi: 10.19664/j.cnki.1002-2392.260133
  • 接收时间:2025-03-31
  • 首发时间:2026-09-17
  • 出版时间:2026-07-20
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期:2025-03-31
  • 修回日期:2025-12-02
基金
国家自然科学基金面上项目(82070382)
山东省泰山学者基金项目(ts20190979)
作者信息
    1.山东中医药大学,山东 济南 250013
    2.山东第一医科大学附属省立医院,山东 济南 250021

通讯作者:

* 董波(1964 -),男,博士,教授,从事中西医结合心系疾病相关研究。
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260133
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏