首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1307269480241976241, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269479684133809, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260134, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1737043200000, receivedDateStr=2025-01-17, revisedDate=1760544000000, revisedDateStr=2025-10-16, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606931982, onlineDateStr=2026-09-17, pubDate=1784476800000, pubDateStr=2026-07-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606931982, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606931982, creator=13701087609, updateTime=1789606931982, updator=13701087609, issue=Issue{id=1307269479684133809, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='7', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1784476800000', pubDateStr='2026-07-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606931849, creator='13701087609', updateTime=1789606931849, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=12, endPage=17, ext={EN=ArticleExt(id=1307269480392971186, articleId=1307269480241976241, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effects of Mulberry Twig Alkaloids on Diabetic Myocardial Fibrosis via the TGF-β1/Smad Signaling Pathway, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To investigate the effect of Mulberry twig (Sangzhi) alkaloids (SZ-A), which is a new traditional Chinese medicinal, on myocardial fibrosis in diabetes mellitus (DM) and its underlying molecular mechanism.

Methods:

The diabetic mouse model was established using high-fat diet combined with streptozotocin injections. Mice were randomly divided into non-diabetic (ND), diabetic (DM), and SZ-A low- (50 mg/kg/d) or high-dose (100 mg/kg/d) groups. Myocardial fibrosis-related proteins (Collagen Ⅰ, TGF-β1, Smad2/3, and their phosphorylated forms) were analyzed by Western blot, while mRNA levels of fibrosis markers (Collagen Ⅰ/Ⅲ, α-SMA, Fn1, Postn) were quantified via qRT-PCR. Molecular docking simulations (AlphaFold2/Autodock) were performed to validate interactions between SZ-A components (DNJ, FGM, DAB) and TGF-β1.

Results:

SZ-A treatment significantly reduced myocardial Collagen deposition in diabetic mice, downregulated mRNA expression of Collagen Ⅰ/Ⅲ, α-SMA, Fn1, and Postn (P < 0.05), and suppressed TGF-β1 expression and Smad2/3 phosphorylation. Molecular docking revealed stable binding affinities between DNJ/FGM/DAB and TGF-β1. Exogenous TGF-β1 administration reversed SZ-A's anti-fibrotic effects, restoring Collagen Ⅰ, TGF-β1, and p-Smad2/3 levels (P <0.05).

Conclusion:

SZ-A ameliorates diabetic myocardial fibrosis by targeting the TGF-β1/Smad signaling pathway, highlighting its therapeutic potential for diabetic cardiomyopathy.

, authors=Sasa KONG1, Mengting WANG1, Han MENG1, Zhaoyu XIE1, Tao XU1, Xuelian FU2, Hui CHE1, 3, *, authorsList=Sasa KONG, Mengting WANG, Han MENG, Zhaoyu XIE, Tao XU, Xuelian FU, Hui CHE, authorCompany=null, correspAuthors=Hui CHE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269480770458547, articleId=1307269480241976241, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于TGF-β1/Smad信号通路探讨桑枝总生物碱对糖尿病心肌纤维化的影响, columnId=1303760926633652690, journalTitle=中医药学报, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的：

探讨中药新药桑枝总生物碱（SZ-A）对糖尿病心肌纤维化的影响及其潜在的分子机制。

方法：

随机抽取6只C57BL/6小鼠作为非糖尿病组，其余采用高脂饮食联合链脲佐菌素建立糖尿病小鼠模型，随机分为糖尿病组及SZ-A低剂量组（50 mg·kg-1·d-1）和SZ-A高剂量组（100 mg·kg-1·d-1），每组6只。采用Western blot技术检测胶原蛋白I（CollagenⅠ）、TGF-β1及Smad通路相关蛋白表达水平，qRT-PCR技术分析纤维化相关标志物mRNA水平，并结合AlphaFold2/Autodock进行分子对接验证。

结果：

SZ-A干预显著降低糖尿病小鼠心肌组织Collagen Ⅰ、Collagen Ⅲ、α-SMA、Fn1和Postn的mRNA表达水平（P < 0.05），抑制TGF-β1表达及Smad2/3磷酸化水平（P < 0.05）。分子对接显示SZ-A主要成分（DNJ、FGM、DAB）与TGF-β1具有稳定结合能力。外源性TGF-β1可逆转SZ-A的抗纤维化作用，显著上调纤维化相关指标（P < 0.05）。

结论：

SZ-A通过靶向调控TGF-β1/Smad信号通路抑制糖尿病心肌纤维化进程。

, authors=孔洒洒1, 王梦亭1, 孟涵1, 谢兆宇1, 徐涛1, 傅雪莲2, 车慧1, 3, *, authorsList=孔洒洒, 王梦亭, 孟涵, 谢兆宇, 徐涛, 傅雪莲, 车慧, authorCompany=null, correspAuthors=车慧, authorNote=

孔洒洒（1998-），女，硕士，研究方向：糖尿病心肌病发病机制研究。

, correspAuthorsNote=
* 车慧（1985 -），女，博士，研究员，研究方向：糖尿病心肌病发病机制研究。
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=z2Y1JJh/BErnyfCEc3bVMg==, magXml=fhdIwN+4iAQFxQ2bBjQeSw==, pdfUrl=null, pdf=Kk+pUE2GXmphh8pfRJXqAw==, pdfFileSize=5388632, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=85qfqd61G89cl642Pf8Vpw==, mapNumber=null, fund=null)}, authors=[Author(id=1307269481223443390, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269481303135168, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481223443390, language=EN, stringName=Sasa KONG, firstName=Sasa, middleName=null, lastName=KONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269481361855425, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481223443390, language=CN, stringName=孔洒洒, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.皖南医学院药学院，安徽 芜湖 241002, bio={"content":"

孔洒洒（1998-），女，硕士，研究方向：糖尿病心肌病发病机制研究。

"}, bioImg=null, bioContent=

孔洒洒（1998-），女，硕士，研究方向：糖尿病心肌病发病机制研究。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)])]), Author(id=1307269481437352899, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269481500267461, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481437352899, language=EN, stringName=Mengting WANG, firstName=Mengting, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269481571570630, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481437352899, language=CN, stringName=王梦亭, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.皖南医学院药学院，安徽 芜湖 241002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)])]), Author(id=1307269481642873800, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269481718371274, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481642873800, language=EN, stringName=Han MENG, firstName=Han, middleName=null, lastName=MENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269481831617483, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481642873800, language=CN, stringName=孟涵, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.皖南医学院药学院，安徽 芜湖 241002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)])]), Author(id=1307269481932280781, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269482045526991, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481932280781, language=EN, stringName=Zhaoyu XIE, firstName=Zhaoyu, middleName=null, lastName=XIE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269482125218768, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481932280781, language=CN, stringName=谢兆宇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.皖南医学院药学院，安徽 芜湖 241002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)])]), Author(id=1307269482188133330, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269482272019412, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269482188133330, language=EN, stringName=Tao XU, firstName=Tao, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269482339128277, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269482188133330, language=CN, stringName=徐涛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.皖南医学院药学院，安徽 芜湖 241002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)])]), Author(id=1307269482406237143, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269484100735961, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269482406237143, language=EN, stringName=Xuelian FU, firstName=Xuelian, middleName=null, lastName=FU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269484180427738, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269482406237143, language=CN, stringName=傅雪莲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.哈尔滨医科大学附属第二医院，黑龙江 哈尔滨 150081, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269481047282615, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=2., ext=[AuthorCompanyExt(id=1307269481059865528, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481047282615, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China), AuthorCompanyExt(id=1307269481068254137, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481047282615, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.哈尔滨医科大学附属第二医院，黑龙江 哈尔滨 150081)])]), Author(id=1307269484247536604, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1307269484335616991, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269484247536604, language=EN, stringName=Hui CHE, firstName=Hui, middleName=null, lastName=CHE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 3, *, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China
3.Center for Basic Research and Innovation of Metabolic Diseases Drugs, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269484419503072, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269484247536604, language=CN, stringName=车慧, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 3, *, address=1.皖南医学院药学院，安徽 芜湖 241002
3.皖南医学院代谢性疾病药物基础研究创新中心，安徽 芜湖 241002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)]), AuthorCompany(id=1307269481135363002, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=3., ext=[AuthorCompanyExt(id=1307269481147945915, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481135363002, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Center for Basic Research and Innovation of Metabolic Diseases Drugs, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269481156334524, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481135363002, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.皖南医学院代谢性疾病药物基础研究创新中心，安徽 芜湖 241002)])])], keywords=[Keyword(id=1307269484511777761, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, language=EN, orderNo=1, keyword=Mulberry twig alkaloids), Keyword(id=1307269484578886626, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, language=EN, orderNo=2, keyword=Cardiac fibrosis), Keyword(id=1307269484645995491, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, language=EN, orderNo=3, keyword=TGF-β1/Smad signaling pathway), Keyword(id=1307269484708910052, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, language=EN, orderNo=4, keyword=Molecular docking), Keyword(id=1307269484767630309, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, language=CN, orderNo=1, keyword=桑枝总生物碱), Keyword(id=1307269484855710694, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, language=CN, orderNo=2, keyword=心肌纤维化), Keyword(id=1307269484935402471, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, language=CN, orderNo=3, keyword=TGF-β1/Smad信号通路), Keyword(id=1307269485002511336, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, language=CN, orderNo=4, keyword=分子对接)], refs=null, funds=[Fund(id=1307269485094786025, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, awardId=2022AH030124, language=CN, fundingSource=安徽省教育厅、安徽省高校优秀青年科研项目(2022AH030124), fundOrder=null, country=null), Fund(id=1307269485170283498, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, awardId=S202310368032; S202310368077, language=CN, fundingSource=安徽省大学生创新创业训练计划项目(S202310368032; S202310368077), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)]), AuthorCompany(id=1307269481047282615, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=2., ext=[AuthorCompanyExt(id=1307269481059865528, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481047282615, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China), AuthorCompanyExt(id=1307269481068254137, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481047282615, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.哈尔滨医科大学附属第二医院，黑龙江 哈尔滨 150081)]), AuthorCompany(id=1307269481135363002, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=3., ext=[AuthorCompanyExt(id=1307269481147945915, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481135363002, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Center for Basic Research and Innovation of Metabolic Diseases Drugs, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269481156334524, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481135363002, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.皖南医学院代谢性疾病药物基础研究创新中心，安徽 芜湖 241002)])], figs=null, attaches=null, journal=Journal(id=1302309566618370119, delFlag=0, nameCn=中医药学报, nameEn=Acta Chinese Medicine and Pharmacology, nameHistory1=null, nameHistory2=null, issn=1002-2392, eissn=null, cn=23-1193/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=waDramTH0+y3s1K97qNETA==, journalPrice=null, startedYear=null, abbrevIsoEn=Acta Chinese Medicine and Pharmacology, journalRemark=null, publicationField=null, createdTime=1788424396424, updatedTime=1788949300331, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=waDramTH0+y3s1K97qNETA==, picEn=VlAd9bvB1BDYZKhr1kPAgA==, jcr=null, cjcr=null, exts=[JournalExt(id=1304511173278326962, language=CN, name=中医药学报, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949300355, updatedTime=1788949300355, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://zyyxb.hljucm.net/ch/author/login.aspx, submissionEditorUrl=http://zyyxb.hljucm.net/ch/login.aspx, submissionReviewUrl=http://zyyxb.hljucm.net/ch/auditor/login.aspx, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304511173332852915, language=EN, name=Acta Chinese Medicine and Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949300368, updatedTime=1788949300368, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://zyyxb.hljucm.net/ch/author/login.aspx, submissionEditorUrl=http://zyyxb.hljucm.net/ch/login.aspx, submissionReviewUrl=http://zyyxb.hljucm.net/ch/auditor/login.aspx, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1302318977290174537, websiteList=[Website(id=1302319176404717747, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302318977290174537, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zyyxb/CN, language=CN, createTime=1788426687575, createBy=18614031015, updateTime=1788427253465, updateBy=18614031015, name=中医药学报-中文, tplId=1146099689490845704, title=中医药学报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302323257894527683, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=articleTextType, value=kx, createTime=1788427660678, updateTime=1788427660678, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257873556160, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=banner, value=null, createTime=1788427660673, updateTime=1788427660673, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257915499206, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=grayFlag, value=0, createTime=1788427660683, updateTime=1788427660683, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257865167551, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=logo, value=https://castjournals.cast.org.cn/joweb/zyyxb/CN/file/pic?fileId=YNbTWTD2kN1YqdKssxyBxQ==, createTime=1788427660671, updateTime=1788427660671, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257923887816, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=minRunFlag, value=0, createTime=1788427660685, updateTime=1788427660685, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257890333378, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zyyxb/CN/file/pic, createTime=1788427660677, updateTime=1788427660677, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257919693511, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=silenceFlag, value=0, createTime=1788427660684, updateTime=1788427660684, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257881944769, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1788427660675, updateTime=1788427660675, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257902916292, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=themeColor, value=null, createTime=1788427660680, updateTime=1788427660680, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323257907110597, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176404717747, code=themeStyle, value=null, createTime=1788427660681, updateTime=1788427660681, creator=18614031015, updator=18614031015)]), Website(id=1302319176459243701, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1302318977290174537, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zyyxb/EN, language=EN, createTime=1788426687588, createBy=18614031015, updateTime=1788427242219, updateBy=18614031015, name=中医药学报-英文, tplId=1146101810881728533, title=Acta Chinese Medicine and Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1302323289888678612, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=articleTextType, value=kx, createTime=1788427668306, updateTime=1788427668306, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289867707089, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=banner, value=null, createTime=1788427668301, updateTime=1788427668301, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289909650135, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=grayFlag, value=0, createTime=1788427668311, updateTime=1788427668311, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289859318480, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=logo, value=https://castjournals.cast.org.cn/joweb/zyyxb/EN/file/pic?fileId=YNbTWTD2kN1YqdKssxyBxQ==, createTime=1788427668299, updateTime=1788427668299, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289926427353, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=minRunFlag, value=0, createTime=1788427668315, updateTime=1788427668315, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289880290003, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zyyxb/EN/file/pic, createTime=1788427668304, updateTime=1788427668304, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289918038744, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=silenceFlag, value=0, createTime=1788427668313, updateTime=1788427668313, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289871901394, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1788427668302, updateTime=1788427668302, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289892872917, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=themeColor, value=null, createTime=1788427668307, updateTime=1788427668307, creator=18614031015, updator=18614031015), WebsiteProps(id=1302323289901261526, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1302319176459243701, code=themeStyle, value=null, createTime=1788427668309, updateTime=1788427668309, creator=18614031015, updator=18614031015)])], journalTitle=中医药学报, weixinUrl=null, journalUrl=http://zyyxb.hljucm.net/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Acta Chinese Medicine and Pharmacology, journalPhotoCn=waDramTH0+y3s1K97qNETA==, journalPhotoEn=VlAd9bvB1BDYZKhr1kPAgA==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260134, detailUrlEn=https://castjournals.cast.org.cn/joweb/zyyxb/EN/10.19664/j.cnki.1002-2392.260134, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zyyxb/CN/PDF/10.19664/j.cnki.1002-2392.260134, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zyyxb/EN/PDF/10.19664/j.cnki.1002-2392.260134, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1784476800000, fullTextJson=null, articleText=null, reference=null)
收藏切换
基于TGF-β1/Smad信号通路探讨桑枝总生物碱对糖尿病心肌纤维化的影响
收藏切换
PDF下载
孔洒洒 1 , 王梦亭 1 , 孟涵 1 , 谢兆宇 1 , 徐涛 1 , 傅雪莲 2 , 车慧 1, 3, *
中医药学报 | 实验研究 2026,54(7): 12-17
收起
收藏切换
中医药学报 |实验研究 2026 , 54 (7) : 12 -17
基于TGF-β1/Smad信号通路探讨桑枝总生物碱对糖尿病心肌纤维化的影响
全屏
[Author(id=1307269481223443390, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269481303135168, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481223443390, language=EN, stringName=Sasa KONG, firstName=Sasa, middleName=null, lastName=KONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269481361855425, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481223443390, language=CN, stringName=孔洒洒, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.皖南医学院药学院，安徽 芜湖 241002, bio={"content":"

孔洒洒（1998-），女，硕士，研究方向：糖尿病心肌病发病机制研究。

"}, bioImg=null, bioContent=

孔洒洒（1998-），女，硕士，研究方向：糖尿病心肌病发病机制研究。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)])]), Author(id=1307269481437352899, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269481500267461, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481437352899, language=EN, stringName=Mengting WANG, firstName=Mengting, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269481571570630, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481437352899, language=CN, stringName=王梦亭, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.皖南医学院药学院，安徽 芜湖 241002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)])]), Author(id=1307269481642873800, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269481718371274, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481642873800, language=EN, stringName=Han MENG, firstName=Han, middleName=null, lastName=MENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269481831617483, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481642873800, language=CN, stringName=孟涵, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.皖南医学院药学院，安徽 芜湖 241002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)])]), Author(id=1307269481932280781, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269482045526991, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481932280781, language=EN, stringName=Zhaoyu XIE, firstName=Zhaoyu, middleName=null, lastName=XIE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269482125218768, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269481932280781, language=CN, stringName=谢兆宇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.皖南医学院药学院，安徽 芜湖 241002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)])]), Author(id=1307269482188133330, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269482272019412, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269482188133330, language=EN, stringName=Tao XU, firstName=Tao, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269482339128277, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269482188133330, language=CN, stringName=徐涛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.皖南医学院药学院，安徽 芜湖 241002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)])]), Author(id=1307269482406237143, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269484100735961, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269482406237143, language=EN, stringName=Xuelian FU, firstName=Xuelian, middleName=null, lastName=FU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269484180427738, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269482406237143, language=CN, stringName=傅雪莲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.哈尔滨医科大学附属第二医院，黑龙江 哈尔滨 150081, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269481047282615, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=2., ext=[AuthorCompanyExt(id=1307269481059865528, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481047282615, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China), AuthorCompanyExt(id=1307269481068254137, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481047282615, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.哈尔滨医科大学附属第二医院，黑龙江 哈尔滨 150081)])]), Author(id=1307269484247536604, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1307269484335616991, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269484247536604, language=EN, stringName=Hui CHE, firstName=Hui, middleName=null, lastName=CHE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 3, *, address=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China
3.Center for Basic Research and Innovation of Metabolic Diseases Drugs, Wannan Medical College, Wuhu 241002, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1307269484419503072, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, authorId=1307269484247536604, language=CN, stringName=车慧, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 3, *, address=1.皖南医学院药学院，安徽 芜湖 241002
3.皖南医学院代谢性疾病药物基础研究创新中心，安徽 芜湖 241002, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1307269480975979444, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=1., ext=[AuthorCompanyExt(id=1307269480984368053, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269480988562358, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269480975979444, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.皖南医学院药学院，安徽 芜湖 241002)]), AuthorCompany(id=1307269481135363002, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, xref=3., ext=[AuthorCompanyExt(id=1307269481147945915, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481135363002, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Center for Basic Research and Innovation of Metabolic Diseases Drugs, Wannan Medical College, Wuhu 241002, China), AuthorCompanyExt(id=1307269481156334524, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269480241976241, companyId=1307269481135363002, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.皖南医学院代谢性疾病药物基础研究创新中心，安徽 芜湖 241002)])])]
孔洒洒1, 王梦亭1, 孟涵1, 谢兆宇1, 徐涛1, 傅雪莲2, 车慧1, 3, *
作者信息
  • 1.皖南医学院药学院，安徽 芜湖 241002
  • 2.哈尔滨医科大学附属第二医院，黑龙江 哈尔滨 150081
  • 3.皖南医学院代谢性疾病药物基础研究创新中心，安徽 芜湖 241002
通讯作者:
* 车慧（1985 -），女，博士，研究员，研究方向：糖尿病心肌病发病机制研究。
作者简介:

孔洒洒（1998-），女，硕士，研究方向：糖尿病心肌病发病机制研究。

Effects of Mulberry Twig Alkaloids on Diabetic Myocardial Fibrosis via the TGF-β1/Smad Signaling Pathway
Sasa KONG1, Mengting WANG1, Han MENG1, Zhaoyu XIE1, Tao XU1, Xuelian FU2, Hui CHE1, 3, *
Affiliations
  • 1.School of Pharmacy, Wannan Medical College, Wuhu 241002, China
  • 2.The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China
  • 3.Center for Basic Research and Innovation of Metabolic Diseases Drugs, Wannan Medical College, Wuhu 241002, China
出版时间: 2026-07-20 doi: 10.19664/j.cnki.1002-2392.260134
文章导航
收藏切换
摘要
收起
目的：

探讨中药新药桑枝总生物碱（SZ-A）对糖尿病心肌纤维化的影响及其潜在的分子机制。

方法：

随机抽取6只C57BL/6小鼠作为非糖尿病组，其余采用高脂饮食联合链脲佐菌素建立糖尿病小鼠模型，随机分为糖尿病组及SZ-A低剂量组（50 mg·kg-1·d-1）和SZ-A高剂量组（100 mg·kg-1·d-1），每组6只。采用Western blot技术检测胶原蛋白I（CollagenⅠ）、TGF-β1及Smad通路相关蛋白表达水平，qRT-PCR技术分析纤维化相关标志物mRNA水平，并结合AlphaFold2/Autodock进行分子对接验证。

结果：

SZ-A干预显著降低糖尿病小鼠心肌组织Collagen Ⅰ、Collagen Ⅲ、α-SMA、Fn1和Postn的mRNA表达水平（P < 0.05），抑制TGF-β1表达及Smad2/3磷酸化水平（P < 0.05）。分子对接显示SZ-A主要成分（DNJ、FGM、DAB）与TGF-β1具有稳定结合能力。外源性TGF-β1可逆转SZ-A的抗纤维化作用，显著上调纤维化相关指标（P < 0.05）。

结论：

SZ-A通过靶向调控TGF-β1/Smad信号通路抑制糖尿病心肌纤维化进程。

桑枝总生物碱  /  心肌纤维化  /  TGF-β1/Smad信号通路  /  分子对接
Objective:

To investigate the effect of Mulberry twig (Sangzhi) alkaloids (SZ-A), which is a new traditional Chinese medicinal, on myocardial fibrosis in diabetes mellitus (DM) and its underlying molecular mechanism.

Methods:

The diabetic mouse model was established using high-fat diet combined with streptozotocin injections. Mice were randomly divided into non-diabetic (ND), diabetic (DM), and SZ-A low- (50 mg/kg/d) or high-dose (100 mg/kg/d) groups. Myocardial fibrosis-related proteins (Collagen Ⅰ, TGF-β1, Smad2/3, and their phosphorylated forms) were analyzed by Western blot, while mRNA levels of fibrosis markers (Collagen Ⅰ/Ⅲ, α-SMA, Fn1, Postn) were quantified via qRT-PCR. Molecular docking simulations (AlphaFold2/Autodock) were performed to validate interactions between SZ-A components (DNJ, FGM, DAB) and TGF-β1.

Results:

SZ-A treatment significantly reduced myocardial Collagen deposition in diabetic mice, downregulated mRNA expression of Collagen Ⅰ/Ⅲ, α-SMA, Fn1, and Postn (P < 0.05), and suppressed TGF-β1 expression and Smad2/3 phosphorylation. Molecular docking revealed stable binding affinities between DNJ/FGM/DAB and TGF-β1. Exogenous TGF-β1 administration reversed SZ-A's anti-fibrotic effects, restoring Collagen Ⅰ, TGF-β1, and p-Smad2/3 levels (P <0.05).

Conclusion:

SZ-A ameliorates diabetic myocardial fibrosis by targeting the TGF-β1/Smad signaling pathway, highlighting its therapeutic potential for diabetic cardiomyopathy.

Mulberry twig alkaloids  /  Cardiac fibrosis  /  TGF-β1/Smad signaling pathway  /  Molecular docking
孔洒洒, 王梦亭, 孟涵, 谢兆宇, 徐涛, 傅雪莲, 车慧. 基于TGF-β1/Smad信号通路探讨桑枝总生物碱对糖尿病心肌纤维化的影响. 中医药学报, 2026 , 54 (7) : 12 -17 . DOI: 10.19664/j.cnki.1002-2392.260134
Sasa KONG, Mengting WANG, Han MENG, Zhaoyu XIE, Tao XU, Xuelian FU, Hui CHE. Effects of Mulberry Twig Alkaloids on Diabetic Myocardial Fibrosis via the TGF-β1/Smad Signaling Pathway[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (7) : 12 -17 . DOI: 10.19664/j.cnki.1002-2392.260134
基金
收起
  • 安徽省教育厅、安徽省高校优秀青年科研项目(2022AH030124)
  • 安徽省大学生创新创业训练计划项目(S202310368032; S202310368077)
文献
收起
参考文献 引证文献
排序方式：
2026年第54卷第7期
PDF下载
4
0
引用本文
BibTeX
文章信息
doi: 10.19664/j.cnki.1002-2392.260134
  • 接收时间：2025-01-17
  • 首发时间：2026-09-17
  • 出版时间：2026-07-20
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2025-01-17
  • 修回日期：2025-10-16
基金
安徽省教育厅、安徽省高校优秀青年科研项目(2022AH030124)
安徽省大学生创新创业训练计划项目(S202310368032; S202310368077)
作者信息
    1.皖南医学院药学院，安徽 芜湖 241002
    2.哈尔滨医科大学附属第二医院，黑龙江 哈尔滨 150081
    3.皖南医学院代谢性疾病药物基础研究创新中心，安徽 芜湖 241002

通讯作者:

* 车慧（1985 -），女，博士，研究员，研究方向：糖尿病心肌病发病机制研究。
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260134
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257（仅加盟咨询）
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持