中医药学报

基于中西医临床病症特点的肺结节动物模型分析

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王特哈斯 ¹ , 王秀珍 ² , 朴蕾 ¹ , 王天龙 ¹ , 付殷 ¹ , 李冀 ¹^,^*

中医药学报 | 研究进展 2026,54(8): 110-118

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中医药学报 |研究进展 2026 , 54 (8) : 110 -118

基于中西医临床病症特点的肺结节动物模型分析

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王特哈斯¹, 王秀珍², 朴蕾¹, 王天龙¹, 付殷¹, 李冀¹^,^*

作者信息

^1.黑龙江中医药大学，黑龙江哈尔滨 150040

^2.黑龙江中医药大学附属第二医院哈南分院，黑龙江哈尔滨 150066

通讯作者:

^* 李冀（1960-），男，博士，教授，博士生导师，主要从事方剂配伍与研究。

作者简介:

王特哈斯（1997-），女，博士研究生，研究方向：中医内科学。

Analysis of Animal Models of Pulmonary Nodules Based on the Characteristics of Clinical Symptoms in Traditional Chinese and Western Medicine

Tehasi WANG¹, Xiuzhen WANG², Lei PIAO¹, Tianlong WANG¹, Yin FU¹, Ji LI¹^,^*

Affiliations

^1.Graduate School of Heilongjiang University of Chinese Medicine, Harbin 150040, China

^2.Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150066, China

出版时间: 2026-08-20 doi: 10.19664/j.cnki.1002-2392.260170

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摘要

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本研究系统分析了近年肺结节动物模型的相关文献，并融合了中西医对其病因病机、诊断及治疗的认识。在此基础上，比较了现有模型的应用特点，并从中医证型与西医指标两方面评估了其临床吻合度。本研究发现，现有模型多通过诱导炎症、纤维化或肿瘤建立，在模拟肺结节影像学表现方面效果较好。西医指标方面，模型在病理、影像等西医指标上的吻合度为70% ~ 85%，表明其能较好地模拟结节的形态与部分病理过程，但在动态进展及系统生理变化方面仍存在局限。中医辨证方面，模型病理表现多对应“痰”“瘀”范畴，与痰瘀互结证的吻合度最高（约60%），但对气虚、阴虚等虚证的整体模拟明显不足。综上所述，现有模型虽可反映肺结节的部分关键特征，尤其在西医指标与痰瘀证型方面表现良好，但仍缺乏对中医整体辨证特别是虚证维度的系统模拟。未来研究可借助多组学动态监测技术，构建更符合中医辨证思想的新型动物模型，以期为肺结节的相关研究提供有益参佐。

关键词

肺结节 / 动物模型 / 病证结合 / 吻合度分析

Abstract

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This study systematically analyzed the relevant literature on animal models of pulmonary nodules in recent years and integrated the understanding of their etiology, pathogenesis, diagnosis, and syndrome differentiation treatment from both traditional Chinese medicine (TCM) and Western medicine. On this basis, the application characteristics of existing models were compared, and their clinical consistency was evaluated from both TCM syndrome types and Western medical indicators. The study found that most existing models were established by inducing inflammation, fibrosis, or tumors, and they performed well in simulating the imaging manifestations of pulmonary nodules. In terms of Western medical indicators, the consistency of the models in pathological and imaging indicators was 70%-85%, indicating that they could well simulate the morphology and some pathological processes of nodules, but there were still limitations in dynamic progression and systemic physiological changes. In terms of TCM syndrome differentiation, the pathological manifestations of the models mostly corresponded to the " phlegm" and " blood stasis" categories, with the highest consistency with the syndrome of phlegm and blood stasis combination (about 60%), but the overall simulation of " deficiency syndromes" such as qi deficiency and yin deficiency was significantly insufficient. In summary, although the existing models can reflect some key features of pulmonary nodules, especially in Western medical indicators and phlegm and blood stasis syndrome types, they still lack systematic simulation of TCM overall syndrome differentiation, especially in the dimension of deficiency syndromes. Future research can utilize multi-omics dynamic monitoring technology to construct new animal models that better conform to the TCM syndrome differentiation concept, in order to provide beneficial references for related research on pulmonary nodules. This study systematically reviewed and analyzed recent literature on animal models of pulmonary nodules. By integrating insights from both traditional Chinese medicine (TCM) and Western medicine regarding the etiology, pathogenesis, clinical diagnostic criteria, and syndrome differentiation and treatment of pulmonary nodules, the study compared the applications of existing animal models and evaluated their clinical relevance based on two criteria: consistency with TCM syndrome patterns and alignment with Western medical indicators. The findings indicate that current animal models are primarily established through induction of inflammation, fibrosis, or tumorigenesis, all of which effectively replicate the imaging characteristics of pulmonary nodules. The concordance with Western medical indicators ranges from 70% to 85%. Pathologically, these models most closely reflect the TCM concepts of phlegm and blood stasis, showing the highest correspondence-up to 60%-with the phlegm-stasis intermingling syndrome. While there is a measurable alignment between the pathological features of these models and the TCM theory of phlegm and stasis, they remain limited in representing systemic deficiency patterns. Therefore, future research should aim to integrate multi-omics dynamic monitoring approaches and develop more sophisticated animal models that better embody the holistic principles of TCM syndrome differentiation, thereby providing more meaningful support for pulmonary nodule research.

Key words

Pulmonary nodules / Animal models / Integration of disease and syndrome / Consistency analysis

引用本文

王特哈斯, 王秀珍, 朴蕾, 王天龙, 付殷, 李冀. 基于中西医临床病症特点的肺结节动物模型分析. 中医药学报, 2026 , 54 (8) : 110 -118 . DOI: 10.19664/j.cnki.1002-2392.260170

Tehasi WANG, Xiuzhen WANG, Lei PIAO, Tianlong WANG, Yin FU, Ji LI. Analysis of Animal Models of Pulmonary Nodules Based on the Characteristics of Clinical Symptoms in Traditional Chinese and Western Medicine[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (8) : 110 -118 . DOI: 10.19664/j.cnki.1002-2392.260170

基金

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全国名中医传承工作室建设项目(国中医药办人教函〔2022〕245号)
中医药传承与创新“百千万”人才工程（岐黄工程）岐黄学者项目(中国中医药人教函〔2018〕 284号)
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教发〔2014〕20号)

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2026年第54卷第8期

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文章信息

doi: 10.19664/j.cnki.1002-2392.260170

接收时间：2025-09-09
首发时间：2026-09-17
出版时间：2026-08-20

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出版历史

收稿日期：2025-09-09
修回日期：2026-03-17

基金

全国名中医传承工作室建设项目(国中医药办人教函〔2022〕245号)

中医药传承与创新“百千万”人才工程（岐黄工程）岐黄学者项目(中国中医药人教函〔2018〕 284号)

国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教发〔2014〕20号)

作者信息

^1.黑龙江中医药大学，黑龙江哈尔滨 150040

^2.黑龙江中医药大学附属第二医院哈南分院，黑龙江哈尔滨 150066

通讯作者:

^* 李冀（1960-），男，博士，教授，博士生导师，主要从事方剂配伍与研究。

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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260170

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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