Article(id=1307264901701980193, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307264617252680149, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260168, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1741104000000, receivedDateStr=2025-03-05, revisedDate=1765209600000, revisedDateStr=2025-12-09, acceptedDate=null, acceptedDateStr=null, onlineDate=1789605840373, onlineDateStr=2026-09-17, pubDate=1787155200000, pubDateStr=2026-08-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789605840373, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789605840373, creator=13701087609, updateTime=1789605840373, updator=13701087609, issue=Issue{id=1307264617252680149, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='8', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1787155200000', pubDateStr='2026-08-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789605772555, creator='13701087609', updateTime=1789605772555, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=98, endPage=103, ext={EN=ArticleExt(id=1307264903287427106, articleId=1307264901701980193, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Efficacy Observation and Safety Analysis of Bushen Huoxue Formula as an Adjuvant to 3HRZE/6HRE Regimen in the Anti-Tuberculosis Treatment of Mid-to-Late Stage Renal Tuberculosis Patients, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the clinical efficacy of 3HRZE/6HRE regimen assisted by Bushen Huoxue Formula in the treatment of patients with intermediate and advanced renal tuberculosis, and to analyze the safety of this therapeutic strategy.
Methods: The clinical data of 122 patients with advanced renal tuberculosis who were treated in Shaanxi Provincial Tuberculosis Prevention and Treatment Hospital from March 2021 to June 2024 were retrospectively analyzed. According to different treatment regimens, they were divided into control group and observation group. 61 patients in the control group were treated with 3HRZE/6HRE regimen alone. 61 patients in the observation group were treated with Bushen Huoxue Formula combined with 3HRZE/6HRE regimen. The course of treatment was 9 months. The clinical efficacy, inflammatory response [interferon-gamma (IFN-γ), interleukin-6 (IL-6), blood sedimentation rate (ESR)], liver and kidney function [azelaic transaminase (AST), blood urea nitrogen (BUN), quantitative 24 h urinary protein (24 h UTP)], quality of life determination scale (QLICD-PT) scores, and the incidence rate of adverse reactions were observed in the two groups.
Results: The total effective rate of the observation group was higher than that of the control group (P <0.05). After treatment, the levels of IFN-γ, IL-6, ESR, BUN, and 24 h UTP were lower than those before treatment in both groups (P <0.05), and the observation group was lower than the control group (P <0.05); and the levels of AST and the scores of each dimension of QLICD-PT were higher than those before treatment, and the observation group was higher than the control group (P <0.05). There was no statistically significant difference in the incidence of adverse reactions in the observation group compared with the control group (P > 0.05).
Conclusion: Bushen Huoxue Formula assisted 3HRZE/6HRE regimen in treating patients with intermediate and advanced renal tuberculosis can significantly improve the therapeutic efficacy and quality of survival, and improve the liver and kidney function, inhibit the expression of inflammation, and have a good safety.
, authors=Ya NAN, Yanpeng LI
*, Fengying JING, Yan ZHANG, Xiying MA, authorsList=Ya NAN, Yanpeng LI, Fengying JING, Yan ZHANG, Xiying MA, authorCompany=null, correspAuthors=Yanpeng LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307264904243728420, articleId=1307264901701980193, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=补肾活血方辅助3HRZE/6HRE方案抗结核治疗中晚期肾结核患者疗效观察及安全性分析, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探究补肾活血方辅助3HRZE/6HRE方案对中晚期肾结核患者的临床疗效，并分析此治疗策略的用药安全性。
方法： 回顾性分析2021年3月—2024年6月于陕西省结核病防治院就诊的122例中晚期肾结核患者临床资料，依据不同治疗方案分为对照组与观察组，每组61例。对照组仅接受3HRZE/6HRE方案治疗，观察组采用补肾活血方辅助3HRZE/6HRE方案治疗，疗程均为9个月，剔除脱落病例后，观察组与对照组每组60例。观察两组临床疗效、炎性反应［干扰素-γ（IFN-γ）、白细胞介素-6（IL-6）、血沉（ESR）］、肝肾功能［谷草转氨酶（AST）、血尿素氮（BUN）、24 h尿蛋白定量（24 h UTP）］、生命质量测定量表（QLICD-PT）评分及不良反应发生率情况。
结果： 观察组总有效率高于对照组（P < 0.05）。治疗后，两组患者IFN-γ、IL-6、ESR、BUN、24 h UTP水平均低于治疗前（P < 0.05），观察组低于对照组（P < 0.05）；且AST水平及QLICD-PT各维度评分均高于治疗前，观察组高于对照组（P <0.05）。观察组不良反应发生率与对照组比较，差异无统计学意义（P > 0.05）。
结论： 补肾活血方辅助3HRZE/6HRE方案治疗中晚期肾结核患者可显著提升治疗效果与生存质量，并能改善肝肾功能、抑制炎性表达，且安全性良好。
, authors=南亚, 李彦鹏
*, 景凤英, 张燕, 马喜迎, authorsList=南亚, 李彦鹏, 景凤英, 张燕, 马喜迎, authorCompany=null, correspAuthors=李彦鹏, authorNote=
南亚（1989-），女，住院医师，从事中医内科、肺结核、肺病相关研究。
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* 李彦鹏（1995-），男，主治医师，从事中医学相关研究。
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南亚（1989-），女，住院医师，从事中医内科、肺结核、肺病相关研究。
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南亚（1989-），女，住院医师，从事中医内科、肺结核、肺病相关研究。
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