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Article(id=1305171225039360513, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260181, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753718400000, receivedDateStr=2025-07-29, revisedDate=1779292800000, revisedDateStr=2026-05-21, acceptedDate=null, acceptedDateStr=null, onlineDate=1789106668957, onlineDateStr=2026-09-11, pubDate=1789833600000, pubDateStr=2026-09-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789106668957, onlineIssueDateStr=2026-09-11, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789106668957, creator=13701087609, updateTime=1789106668957, updator=13701087609, issue=Issue{id=1305171206701871960, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='9', pageStart='1', pageEnd='133', issueExtLink='null', onlineDate='null', pubDate='1789833600000', pubDateStr='2026-09-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1789106664586, creator='13701087609', updateTime=1789106805687, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1305171798593663109, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1305171798593663110, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=60, endPage=64, ext={EN=ArticleExt(id=1305171225567842818, articleId=1305171225039360513, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=A Prospective Cohort Study on the Intervention of Shiwei Shengxue Decoction in Advanced Non-Small-Cell Lung Cancer with Cachexia (Qi and Blood Deficiency Syndrome), columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To investigate the efficacy and safety of Shiwei Shengxue Decoction in improving the nutritional status of patients with advanced non-small cell lung cancer (NSCLC) cachexia (Qi and Blood Deficiency Syndrome).

Methods:

A prospective cohort study design was adopted. Patients with advanced NSCLC who met the diagnostic criteria for Qi and Blood Deficiency Syndrome and cancer cachexia, admitted to Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, and Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, from March 2023 to March 2024, were enrolled. Based on whether they received Shiwei Shengxue Decoction (treatment for≥4 weeks), patients were naturally assigned to an exposed group and a non-exposed group. Both groups received conventional nutritional treatment.

Results:

After propensity score matching (PSM), 45 pairs of patients were included. The total effective rate for improving nutritional status in the exposed group was 77.8% (35/42), which was significantly higher than that in the non-exposed group (48.9%, 22/45), with a statistically significant difference (P < 0. 05). The exposed group showed superior improvements in increasing food intake, maintaining body weight, enhancing grip strength, and raising serum hemoglobin (Hgb) levels compared to the non-exposed group (P <0.05). However, no statistically significant differences were observed in KPS scores or serum albumin (ALB) levels between the two groups (P > 0.05). No adverse events were reported during the study period.

Conclusion:

Shiwei Shengxue Decoction can effectively improve the nutritional status of patients with advanced NSCLC cachexia (Qi and Blood Deficiency Syndrome) with a favorable safety profile.

, authors=Xu ZHANG1, Guowang YANG1, *, Li TONG1, Qiongyang LI1, Yi YUAN1, Yanxin MA1, Chi ZHANG2, Xiao DU2, authorsList=Xu ZHANG, Guowang YANG, Li TONG, Qiongyang LI, Yi YUAN, Yanxin MA, Chi ZHANG, Xiao DU, authorCompany=null, correspAuthors=Guowang YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1305171226272485891, articleId=1305171225039360513, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=十味升血汤干预进展期非小细胞肺癌恶病质(气血两虚证)的前瞻性队列研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的：

探讨十味升血汤干预进展期非小细胞肺癌恶病质（气血两虚证）患者营养状况的有效性及安全性。

方法：

采用前瞻性队列研究设计，纳入2023年3月—2024年3月首都医科大学附属北京中医医院及北京中医医院顺义医院收治的符合气血两虚证、癌性恶病质诊断的进展期非小细胞肺癌患者。根据是否应用十味升血汤自然形成暴露组（治疗≥4周）和非暴露组，两组均接受常规营养治疗。

结果：

经倾向评分匹配（PSM）后共纳入45对患者。暴露组营养状况改善总有效率为77.8% （35/45）显著高于非暴露组的48.9% （22/45），差异有统计学意义（P < 0.05）。暴露组在增加患者进食量，维持体质量，提高握力及血清Hgb水平均优于非暴露组（P < 0.05），但在KPS评分和血清ALB水平差异无统计学意义（P > 0.05）。研究期间未报告不良事件。

结论：

十味升血汤可有效改善进展期非小细胞肺癌恶病质（气血两虚证）患者的营养状况，且安全性良好。

, authors=张旭1, 杨国旺1, *, 佟丽1, 栗琼洋1, 袁怿1, 马艳新1, 张驰2, 杜霄2, authorsList=张旭, 杨国旺, 佟丽, 栗琼洋, 袁怿, 马艳新, 张驰, 杜霄, authorCompany=null, correspAuthors=杨国旺, authorNote=

张旭（1992-），女，博士，主治医师，研究方向：中西医结合临床营养与代谢调节研究。

, correspAuthorsNote=
* 杨国旺（1969 -），男，博士，主任医师，博士生导师，研究方向：中医药治疗肿瘤并发症及机制研究。
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张旭（1992-），女，博士，主治医师，研究方向：中西医结合临床营养与代谢调节研究。

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张旭（1992-），女，博士，主治医师，研究方向：中西医结合临床营养与代谢调节研究。

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十味升血汤干预进展期非小细胞肺癌恶病质(气血两虚证)的前瞻性队列研究
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张旭 1 , 杨国旺 1, * , 佟丽 1 , 栗琼洋 1 , 袁怿 1 , 马艳新 1 , 张驰 2 , 杜霄 2
中医药学报 | 临床研究 2026,54(9): 60-64
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中医药学报 |临床研究 2026 , 54 (9) : 60 -64
十味升血汤干预进展期非小细胞肺癌恶病质(气血两虚证)的前瞻性队列研究
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张旭（1992-），女，博士，主治医师，研究方向：中西医结合临床营养与代谢调节研究。

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张旭（1992-），女，博士，主治医师，研究方向：中西医结合临床营养与代谢调节研究。

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张旭1, 杨国旺1, *, 佟丽1, 栗琼洋1, 袁怿1, 马艳新1, 张驰2, 杜霄2
作者信息
  • 1．首都医科大学附属北京中医医院，北京 100010
  • 2．首都医科大学附属北京中医医院顺义医院，北京 101300
通讯作者:
* 杨国旺（1969 -），男，博士，主任医师，博士生导师，研究方向：中医药治疗肿瘤并发症及机制研究。
作者简介:

张旭（1992-），女，博士，主治医师，研究方向：中西医结合临床营养与代谢调节研究。

A Prospective Cohort Study on the Intervention of Shiwei Shengxue Decoction in Advanced Non-Small-Cell Lung Cancer with Cachexia (Qi and Blood Deficiency Syndrome)
Xu ZHANG1, Guowang YANG1, *, Li TONG1, Qiongyang LI1, Yi YUAN1, Yanxin MA1, Chi ZHANG2, Xiao DU2
Affiliations
  • 1.Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China
  • 2.Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 101300, China
出版时间: 2026-09-20 doi: 10.19664/j.cnki.1002-2392.260181
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摘要
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目的：

探讨十味升血汤干预进展期非小细胞肺癌恶病质（气血两虚证）患者营养状况的有效性及安全性。

方法：

采用前瞻性队列研究设计，纳入2023年3月—2024年3月首都医科大学附属北京中医医院及北京中医医院顺义医院收治的符合气血两虚证、癌性恶病质诊断的进展期非小细胞肺癌患者。根据是否应用十味升血汤自然形成暴露组（治疗≥4周）和非暴露组，两组均接受常规营养治疗。

结果：

经倾向评分匹配（PSM）后共纳入45对患者。暴露组营养状况改善总有效率为77.8% （35/45）显著高于非暴露组的48.9% （22/45），差异有统计学意义（P < 0.05）。暴露组在增加患者进食量，维持体质量，提高握力及血清Hgb水平均优于非暴露组（P < 0.05），但在KPS评分和血清ALB水平差异无统计学意义（P > 0.05）。研究期间未报告不良事件。

结论：

十味升血汤可有效改善进展期非小细胞肺癌恶病质（气血两虚证）患者的营养状况，且安全性良好。

进展期非小细胞肺癌  /  营养状况  /  恶病质  /  十味升血汤  /  队列研究
Objective:

To investigate the efficacy and safety of Shiwei Shengxue Decoction in improving the nutritional status of patients with advanced non-small cell lung cancer (NSCLC) cachexia (Qi and Blood Deficiency Syndrome).

Methods:

A prospective cohort study design was adopted. Patients with advanced NSCLC who met the diagnostic criteria for Qi and Blood Deficiency Syndrome and cancer cachexia, admitted to Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, and Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, from March 2023 to March 2024, were enrolled. Based on whether they received Shiwei Shengxue Decoction (treatment for≥4 weeks), patients were naturally assigned to an exposed group and a non-exposed group. Both groups received conventional nutritional treatment.

Results:

After propensity score matching (PSM), 45 pairs of patients were included. The total effective rate for improving nutritional status in the exposed group was 77.8% (35/42), which was significantly higher than that in the non-exposed group (48.9%, 22/45), with a statistically significant difference (P < 0. 05). The exposed group showed superior improvements in increasing food intake, maintaining body weight, enhancing grip strength, and raising serum hemoglobin (Hgb) levels compared to the non-exposed group (P <0.05). However, no statistically significant differences were observed in KPS scores or serum albumin (ALB) levels between the two groups (P > 0.05). No adverse events were reported during the study period.

Conclusion:

Shiwei Shengxue Decoction can effectively improve the nutritional status of patients with advanced NSCLC cachexia (Qi and Blood Deficiency Syndrome) with a favorable safety profile.

Advanced non-small cell lung cancer  /  Nutritional status  /  Cachexia  /  Shiwei Shengxue Decoction  /  Cohort study
张旭, 杨国旺, 佟丽, 栗琼洋, 袁怿, 马艳新, 张驰, 杜霄. 十味升血汤干预进展期非小细胞肺癌恶病质(气血两虚证)的前瞻性队列研究. 中医药学报, 2026 , 54 (9) : 60 -64 . DOI: 10.19664/j.cnki.1002-2392.260181
Xu ZHANG, Guowang YANG, Li TONG, Qiongyang LI, Yi YUAN, Yanxin MA, Chi ZHANG, Xiao DU. A Prospective Cohort Study on the Intervention of Shiwei Shengxue Decoction in Advanced Non-Small-Cell Lung Cancer with Cachexia (Qi and Blood Deficiency Syndrome)[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (9) : 60 -64 . DOI: 10.19664/j.cnki.1002-2392.260181
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  • 国家自然科学基金青年基金项目(82405507)
  • 北京中医医院院级课题暨两院合作课题(LYYB202217)
  • 北京市属医院科研培育计划项目(PZ2024029)
  • 北京中医医院院级青年职工创新工作室项目(2025-013)
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2026年第54卷第9期
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doi: 10.19664/j.cnki.1002-2392.260181
  • 接收时间：2025-07-29
  • 首发时间：2026-09-11
  • 出版时间：2026-09-20
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  • 收稿日期：2025-07-29
  • 修回日期：2026-05-21
基金
国家自然科学基金青年基金项目(82405507)
北京中医医院院级课题暨两院合作课题(LYYB202217)
北京市属医院科研培育计划项目(PZ2024029)
北京中医医院院级青年职工创新工作室项目(2025-013)
作者信息
    1．首都医科大学附属北京中医医院，北京 100010
    2．首都医科大学附属北京中医医院顺义医院，北京 101300

通讯作者:

* 杨国旺（1969 -），男，博士，主任医师，博士生导师，研究方向：中医药治疗肿瘤并发症及机制研究。
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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260181
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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