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The patients were randomly divided into a control group and an observation group, with 50 cases in each group. Case data were sourced from the hospital's electronic medical record system. The control group received conventional Western medicine treatment, while the observation group received conventional Western medicine combined with modified Banxia Xiexin Decoction. After 4 weeks of treatment, the efficacy of the two groups was compared. Before treatment, at week 1, and at week 4 of treatment, Traditional Chinese Medicine syndrome scores (epigastric fullness, reduced appetite, fatigue), gastric antrum contraction frequency, gastric antrum contraction amplitude, gastric half - emptying time, motilin, gastrin, and somatostatin (SS) were compared between the two groups. Adverse reactions in both groups were also recorded.Results: After 4 weeks of treatment, the total effective rate in the observation group was higher than that in the control group (P < 0.05) ; before treatment, at 1 week, and at 4 weeks of treatment, scores of traditional Chinese medicine (TCM) syndromes such as epigastric and abdominal fullness, reduced appetite, and fatigue, as well as antral contraction amplitude, gastric half - emptying time, and SS showed a gradual decreasing trend (P < 0.05), with the observation group lower than the control group (P <0.05). Antral contraction frequency, motilin, and gastrin showed a gradual increasing trend (P < 0.05), with the observation group higher than the control group. The main effects between groups were significant (P <0.05).Conclusion: modified Banxia Xiexin Decoction with significantly effective in treating functional dyspepsia (FD) can effectively improve patients' gastrointestinal motility and gastrointestinal hormone levels, and relieve clinical symptoms., authors=LI Li1 , HUA Haibing1 , SHEN Ming1 , ZHONG Xiaofeng1 , authorsList=LI Li, HUA Haibing, SHEN Ming, ZHONG Xiaofeng, authorCompany=1 Department of Gastroenterology, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin 214400, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=2021年度江苏省中医药科技发展计划项目 (ZX2021A1); 花海兵无锡市名中医工作室 (锡中医〔2023〕2号)), CN=ArticleExt(id=1304438831583879805, articleId=1304438831365775996, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=半夏泻心汤治疗功能性消化不良的临床研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=目的: 分析加味半夏泻心汤治疗功能性消化不良(FD)的效果。 方法: 回顾性纳入2024年1月—2024年12月江阴市中医院门诊收治的100例FD患者作为研究对象,按照随机数表法分为对照组和观察组,每组50例,病例来源于江阴市中医院电子病例系统。对照组采取常规西药治疗,观察组采取常规西药联合加味半夏泻心汤治疗。治疗4周后比较两组疗效;于治疗前、治疗1周、治疗4周,比较两组中医证候积分(脘腹痞闷、饮食减少、疲乏无力)、胃窦收缩频率、胃窦收缩幅度、胃半排空时间、胃动素、胃泌素、生长抑素(SS);记录两组不良反应发生情况。 结果: 治疗4周时,观察组总有效率高于对照组(P < 0.05);治疗前、治疗1周、治疗4周,两组脘腹痞闷、饮食减少、疲乏无力中医证候积分、胃窦收缩幅度、胃半排空时间、SS呈逐渐下降趋势(P < 0.05),观察组低于对照组(P < 0.05),胃窦收缩频率、胃动素、胃泌素呈逐渐上升趋势(P < 0.05),观察组高于对照组,两组组别主效应显著(P < 0.05)。 结论: 加味半夏泻心汤治疗FD效果显著,可有效改善患者胃肠动力及胃肠激素水平,缓解临床症状。, authors=李丽1 , 花海兵1 , 沈明1 , 钟晓锋1 , authorsList=李丽, 花海兵, 沈明, 钟晓锋, authorCompany=1 江阴市中医院脾胃病科,江苏 江阴 214400, correspAuthors=* 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中医药学报
|临床研究
2026
, 54
(2) :
103
-107
半夏泻心汤治疗功能性消化不良的临床研究
全屏
李丽1 , 花海兵1 , 沈明1 , 钟晓锋1
作者信息
1 江阴市中医院脾胃病科,江苏 江阴 214400
通讯作者:
* 钟晓锋(1985-),男,副主任中医师,从事功能性胃肠病相关研究。
作者简介:
李丽(1986-),女,硕士,副主任中医师,从事功能性胃肠病相关研究。
Clinical Study on Banxia Xiexin Decoction for the Treatment of Functional Dyspepsia
LI Li1 , HUA Haibing1 , SHEN Ming1 , ZHONG Xiaofeng1
Affiliations
1 Department of Gastroenterology, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin 214400, China
doi: 10.19664/j.cnki.1002-2392.260043
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目的: 分析加味半夏泻心汤治疗功能性消化不良(FD)的效果。 方法: 回顾性纳入2024年1月—2024年12月江阴市中医院门诊收治的100例FD患者作为研究对象,按照随机数表法分为对照组和观察组,每组50例,病例来源于江阴市中医院电子病例系统。对照组采取常规西药治疗,观察组采取常规西药联合加味半夏泻心汤治疗。治疗4周后比较两组疗效;于治疗前、治疗1周、治疗4周,比较两组中医证候积分(脘腹痞闷、饮食减少、疲乏无力)、胃窦收缩频率、胃窦收缩幅度、胃半排空时间、胃动素、胃泌素、生长抑素(SS);记录两组不良反应发生情况。 结果: 治疗4周时,观察组总有效率高于对照组(P < 0.05);治疗前、治疗1周、治疗4周,两组脘腹痞闷、饮食减少、疲乏无力中医证候积分、胃窦收缩幅度、胃半排空时间、SS呈逐渐下降趋势(P < 0.05),观察组低于对照组(P < 0.05),胃窦收缩频率、胃动素、胃泌素呈逐渐上升趋势(P < 0.05),观察组高于对照组,两组组别主效应显著(P < 0.05)。 结论: 加味半夏泻心汤治疗FD效果显著,可有效改善患者胃肠动力及胃肠激素水平,缓解临床症状。
功能性消化不良
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半夏泻心汤
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胃动力
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胃肠激素
Objective: To analyze the effect of modified Banxia Xiexin Decoction in treating functional dyspepsia (FD).Methods: A total of 100 FD patients treated in the outpatient department of Jiangyin Traditional Chinese Medicine Hospital from January 2024 to December 2024 were retrospectively included as study subjects. The patients were randomly divided into a control group and an observation group, with 50 cases in each group. Case data were sourced from the hospital's electronic medical record system. The control group received conventional Western medicine treatment, while the observation group received conventional Western medicine combined with modified Banxia Xiexin Decoction. After 4 weeks of treatment, the efficacy of the two groups was compared. Before treatment, at week 1, and at week 4 of treatment, Traditional Chinese Medicine syndrome scores (epigastric fullness, reduced appetite, fatigue), gastric antrum contraction frequency, gastric antrum contraction amplitude, gastric half - emptying time, motilin, gastrin, and somatostatin (SS) were compared between the two groups. Adverse reactions in both groups were also recorded.Results: After 4 weeks of treatment, the total effective rate in the observation group was higher than that in the control group (P < 0.05) ; before treatment, at 1 week, and at 4 weeks of treatment, scores of traditional Chinese medicine (TCM) syndromes such as epigastric and abdominal fullness, reduced appetite, and fatigue, as well as antral contraction amplitude, gastric half - emptying time, and SS showed a gradual decreasing trend (P < 0.05), with the observation group lower than the control group (P <0.05). Antral contraction frequency, motilin, and gastrin showed a gradual increasing trend (P < 0.05), with the observation group higher than the control group. The main effects between groups were significant (P <0.05).Conclusion: modified Banxia Xiexin Decoction with significantly effective in treating functional dyspepsia (FD) can effectively improve patients' gastrointestinal motility and gastrointestinal hormone levels, and relieve clinical symptoms.
Functional dyspepsia
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Banxia Xiexin Decoction
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Gastric motility
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Gastrointestinal hormones
李丽, 花海兵, 沈明, 钟晓锋.
半夏泻心汤治疗功能性消化不良的临床研究.
中医药学报,
2026
, 54
(2)
: 103
-107
.
DOI: 10.19664/j.cnki.1002-2392.260043
LI Li, HUA Haibing, SHEN Ming, ZHONG Xiaofeng.
Clinical Study on Banxia Xiexin Decoction for the Treatment of Functional Dyspepsia[J].
Acta Chinese Medicine and Pharmacology ,
2026
, 54
(2)
: 103
-107
.
DOI: 10.19664/j.cnki.1002-2392.260043
2026年第54卷第2期
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doi: 10.19664/j.cnki.1002-2392.260043
接收时间:2025-02-28
首发时间:2026-09-09
https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260043
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