中医药学报

当归芍药散联合小剂量低分子肝素钙治疗早发型重度子痫前期的临床研究

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吴志兵 ¹ , 陆瑞 ¹ , 姜雪 ¹ , 张博 ²^,^*

中医药学报 | 临床研究 2026,54(10): 117-121

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中医药学报 |临床研究 2026 , 54 (10) : 117 -121

当归芍药散联合小剂量低分子肝素钙治疗早发型重度子痫前期的临床研究

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吴志兵¹, 陆瑞¹, 姜雪¹, 张博²^,^*

作者信息

^1.南京中医药大学沭阳附属医院妇产科，江苏　沭阳　223600

^2.江苏省人民医院宿迁医院中医科，江苏　宿迁　223800

通讯作者:

^* 张博（1987-），女，硕士，副主任中医师，从事心血管疾病及相关妊娠病的发病机制研究。

作者简介:

吴志兵（1992-），男，硕士，副主任中医师，从事中医药治疗妇产科疾病相关研究。

Clinical Study on Danggui Shaoyao Powder Combined Low-dose and Low-molecular-weight Heparin Calcium in the Treatment of Early-onset Severe Preeclampsia

Zhibing WU¹, Rui LU¹, Xue JIANG¹, Bo ZHANG²^,^*

Affiliations

^1.Department of Obstetrics and Gynecology, Shuyang Affiliated Hospital of Nanjing University of Chinese Medicine, Shuyang 223600, China

^2.Department of Traditional Chinese Medicine, Suqian Branch, Jiangsu Province Hospital, Suqian 223800, China

出版时间: 2026-10-20 doi: 10.19664/j.cnki.1002-2392.260213

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摘要

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目的：

探讨当归芍药散联合小剂量低分子肝素钙治疗早发型重度子痫前期的临床疗效。

方法：

纳入2022年9月—2024年9月于南京中医药大学沭阳附属医院收治的早发型重度子痫前期患者96例，将其随机分为观察组和对照组，每组48例，对照组皮下注射低分子肝素钙，观察组在对照组基础上联合当归芍药散治疗。治疗1周后，比较两组的中医证候评分、血压、血管内皮细胞黏附因子-1（VCAM-1）、血管紧张素Ⅱ（AngII）、凝血指标[凝血酶时间（TT）、凝血酶原时间（PT）、血浆纤维蛋白原（FIB）、D二聚体]、蛋白尿[24 h尿蛋白定量、尿微量白蛋白（mAlb）、尿转铁蛋白（TRF）、尿α1微球蛋白（α1-MG）]、围产期结局及不良反应。

结果：

治疗后，两组头晕头痛、视力模糊、腹部或胸部不适、水肿评分下降（P<0.05），观察组低于对照组（P<0.05）。治疗后，两组PT、TT延长（P<0.05），观察组长于对照组（P<0.05）；两组FIB、D二聚体下降（P<0.05），观察组低于对照组（P<0.05）。治疗后，两组舒张压、收缩压、血清VCAM-1、血清AngII、24 h尿蛋白定量、mAlb、TRF、α1-MG下降（P<0.05），观察组低于对照组（P<0.05）。观察组分娩孕周长于对照组（P<0.05），新生儿出生体质量高于对照组（P<0.05），胎儿生长受限、胎儿窘迫及新生儿窒息的发生率低于对照组（P<0.05）。

结论：

当归芍药散治疗早发型重度子痫前期，有助于减轻患者的临床症状，改善围产期结局。

关键词

早发型重度子痫前期 / 低分子肝素 / 当归芍药散 / 血不利 / 围产期结局

Abstract

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Objective:

To explore the clinical efficacy of Danggui Shaoyao Powder combined with low-dose low-molecular-weight heparin calcium in the treatment of early-onset severe preeclampsia.

Methods:

96 patients with early-onset severe preeclampsia admitted to Shuyang Affiliated Hospital of Nanjing University of Chinese Medicine from September 2022 to September 2024 were included.96 patients with early-onset severe preeclampsia were randomly divided into an observation group and a control group, with 48 cases in each group. The control group received subcutaneous injection of low molecular weight heparin calcium, while the observation group received treatment in combination with Danggui Shaoyao Powder. After one week of treatment, the traditional Chinese medicine syndrome scores, blood pressure, vascular endothelial cell adhesion molecule-1 (VCAM-1), angiotensinⅡ (AngII), coagulation indicators [thrombin time (TT), prothrombin time (PT), plasma fibrinogen (FIB), D-dimer], proteinuria [24-hour urine protein quantification, microalbumin (mAlb), transferrin (TRF), urinary alpha 1-microglobulin (α 1-MG)], perinatal outcomes, and adverse reactions were compared between the two groups.

Results:

After treatment, the scores of dizziness, headache, blurred vision, abdominal or chest discomfort, and edema decreased in both groups (P<0.05), and the observation group was lower than the control group (P<0.05). After treatment, both groups showed prolonged PT and TT (P<0.05), with the observation group exhibiting longer durations than the control group (P<0.05). Both groups experienced a decrease in FIB and D-dimer levels (P<0.05), with the observation group showing lower levels than the control group (P<0.05). After treatment, both groups showed a decrease in diastolic blood pressure, systolic blood pressure, serum VCAM-1, serum AngII, 24-hour urinary protein quantification, mAlb, TRF, and α 1-MG (P<0.05), with the observation group being lower than the control group (P<0.05). The gestational age of delivery in the observation group was longer than that in the control group (P<0.05), and the birth weight of newborns was higher than that in the control group (P<0.05). Additionally, the incidence of fetal growth restriction, fetal distress, and neonatal asphyxia was lower in the observation group than in the control group (P<0.05).

Conclusion:

Danggui Shaoyao Powder in the treatment of early-onset severe preeclampsia helps alleviate clinical symptoms and improve perinatal outcomes.

Key words

Early onset severe preeclampsia / Low molecular weight heparin / Danggui Shaoyao Powder / Blood disadvantage / Perinatal outcome

引用本文

吴志兵, 陆瑞, 姜雪, 张博. 当归芍药散联合小剂量低分子肝素钙治疗早发型重度子痫前期的临床研究. 中医药学报, 2026 , 54 (10) : 117 -121 . DOI: 10.19664/j.cnki.1002-2392.260213

Zhibing WU, Rui LU, Xue JIANG, Bo ZHANG. Clinical Study on Danggui Shaoyao Powder Combined Low-dose and Low-molecular-weight Heparin Calcium in the Treatment of Early-onset Severe Preeclampsia[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (10) : 117 -121 . DOI: 10.19664/j.cnki.1002-2392.260213

基金

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江苏省卫生健康委青年项目(ZQ2024015)
宿迁市中医药科技项目(MS202305)

参考文献

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2026年第54卷第10期

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文章信息

doi: 10.19664/j.cnki.1002-2392.260213

接收时间：2025-04-30
首发时间：2026-10-14
出版时间：2026-10-20

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出版历史

收稿日期：2025-04-30
修回日期：2026-05-29

基金

江苏省卫生健康委青年项目(ZQ2024015)

宿迁市中医药科技项目(MS202305)

作者信息

^1.南京中医药大学沭阳附属医院妇产科，江苏　沭阳　223600

^2.江苏省人民医院宿迁医院中医科，江苏　宿迁　223800

通讯作者:

^* 张博（1987-），女，硕士，副主任中医师，从事心血管疾病及相关妊娠病的发病机制研究。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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