中医药学报

蛇床子散加减熏洗配合高强度聚焦超声对外阴白色病变患者中医证候积分和神经生长因子水平的影响

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叶荣蕾 , 张俊杰 , 王晓宇

中医药学报 | 临床研究 2026,54(10): 89-94

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中医药学报 |临床研究 2026 , 54 (10) : 89 -94

蛇床子散加减熏洗配合高强度聚焦超声对外阴白色病变患者中医证候积分和神经生长因子水平的影响

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叶荣蕾, 张俊杰, 王晓宇

作者信息

衡水市妇幼保健院，河北　衡水　053000

作者简介:

叶荣蕾（1985-），女，主治医师，从事中医妇科相关研究。

Effects of Modified Shechuangzi Powder Fumigation and Washing Combined with High-Intensity Focused Ultrasound on Traditional Chinese Medicine Syndrome Scores and Nerve Growth Factor Levels in Patients with Vulvar Leukoplakia

Ronglei YE, Junjie ZHANG, Xiaoyu WANG

Affiliations

Hengshui Maternal and Child Health Hospital, Hengshui 053000, China

出版时间: 2026-10-20 doi: 10.19664/j.cnki.1002-2392.260208

文章导航

摘要

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目的：

探究蛇床子散加减熏洗配合高强度聚焦超声（HIFU）治疗外阴白色病变（WLV）的效果及对患者中医证候积分、神经生长因子（NGF）水平的影响。

方法：

选取衡水市妇幼保健院2023年1月—2024年6月就诊的肝肾阴虚证WLV患者196例，按随机数字表法分为联合组与对照组，每组98例。联合组与对照组WLV患者因失访分别脱落1例与2例，最终各自纳入统计分析为97例与96例。对照组接受HIFU治疗，联合组在对照组基础上加用蛇床子散加减熏洗。评估两组疗效、治疗前后中医证候积分及皮肤病生活质量指数（DLQI）评分，测定治疗前后血清及外阴组织相关指标，统计两组不良反应及随访6个月复发情况。

结果：

联合组治疗总有效率为100.00%，高于对照组的90.63%（P<0.01）；联合组治疗后中医证候积分、DLQI评分均明显低于对照组（P<0.05）；血清指标方面，联合组治疗后血清NGF、P物质（SP）、C反应蛋白（CRP）、白细胞介素-6（IL-6）水平均明显低于对照组（P<0.05）；外阴组织指标方面，联合组治疗后NGF阳性表达的光密度（OD）值明显低于对照组（P<0.05），血管内皮生长因子（VEGF）阳性表达的OD值明显高于对照组（P<0.05）；两组不良反应对比无明显差异（P>0.05）；联合组随访6个月复发率为3.09%，低于对照组的10.42%（P<0.05）。

结论：

蛇床子散加减熏洗联合HIFU治疗WLV安全有效，能明显减少患者中医证候积分，下调NGF及促炎因子水平，上调VEGF表达，降低复发率，且能改善其生活质量。

关键词

外阴白色病变 / 蛇床子散 / 熏洗 / 高强度聚焦超声 / 中医证候积分 / 神经生长因子

Abstract

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Objective:

To investigate the efficacy of modified Shechuangzi Powder fumigation and washing combined with high-intensity focused ultrasound (HIFU) in the treatment of vulvar leukoplakia (WLV) and its effects on traditional Chinese medicine (TCM) syndrome scores and nerve growth factor (NGF) levels in patients.

Methods:

A total of 196 WLV patients with liver-kidney yin deficiency pattern treated at Hengshui Maternal and Child Health Hospital from January 2023 to June 2024 were selected and randomly divided into a combination group and a control group using a random number table method, with 98 cases in each group. Due to loss to follow-up, 1 case in the combination group and 2 cases in the control group were excluded, resulting in 97 and 96 cases being included in the final statistical analysis, respectively. The control group received HIFU treatment, while the combination group received additional modified Shechuangzi Powder fumigation and washing on the basis of HIFU. The therapeutic efficacy, TCM syndrome scores, and Dermatology Life Quality Index (DLQI) scores were evaluated before and after treatment. Serum and vulvar tissue-related indicators were measured before and after treatment. Adverse reactions and recurrence within 6 months of follow-up were recorded in both groups.

Results:

The total effective rate in the combination group was 100.00%, which was higher than that in the control group (90.63%) (P<0.01). After treatment, TCM syndrome scores and DLQI scores in the combination group were significantly lower than those in the control group (P<0.05). Regarding serum indicators, the levels of NGF, substance P (SP), C-reactive protein (CRP), and interleukin-6 (IL-6) in the combination group after treatment were significantly lower than those in the control group (P<0.05). Regarding vulvar tissue indicators, the optical density (OD) value of NGF positive expression in the combination group after treatment was significantly lower than that in the control group (P<0.05), while the OD value of vascular endothelial growth factor (VEGF) positive expression was significantly higher than that in the control group (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). The 6-month recurrence rate in the combination group was 3.09%, which was lower than that in the control group (10.42%) (P<0.05).

Conclusion:

Modified Shechuangzi Powder fumigation and washing combined with HIFU is safe and effective in the treatment of WLV. It can significantly reduce TCM syndrome scores, down-regulate NGF and pro-inflammatory factor levels, upregulate VEGF expression, reduce the recurrence rate, and improve patients' quality of life.

Key words

Vulvar leukoplakia / Shechuangzi Powder / Fumigation and washing / High-intensity focused ultrasound / Traditional Chinese medicine syndrome score / Nerve growth factor

引用本文

叶荣蕾, 张俊杰, 王晓宇. 蛇床子散加减熏洗配合高强度聚焦超声对外阴白色病变患者中医证候积分和神经生长因子水平的影响. 中医药学报, 2026 , 54 (10) : 89 -94 . DOI: 10.19664/j.cnki.1002-2392.260208

Ronglei YE, Junjie ZHANG, Xiaoyu WANG. Effects of Modified Shechuangzi Powder Fumigation and Washing Combined with High-Intensity Focused Ultrasound on Traditional Chinese Medicine Syndrome Scores and Nerve Growth Factor Levels in Patients with Vulvar Leukoplakia[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (10) : 89 -94 . DOI: 10.19664/j.cnki.1002-2392.260208

基金

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衡水市科技计划项目(2023014015Z)

参考文献

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参考文献引证文献

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2026年第54卷第10期

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文章信息

doi: 10.19664/j.cnki.1002-2392.260208

接收时间：2025-04-02
首发时间：2026-10-14
出版时间：2026-10-20

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收稿日期：2025-04-02
修回日期：2026-03-20

基金

衡水市科技计划项目(2023014015Z)

作者信息

衡水市妇幼保健院，河北　衡水　053000

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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