中医药学报

从线粒体生物发生与自噬机制探讨益气活血法促进糖尿病足溃疡愈合的科学内涵

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常金霞 ¹ , 杨俏丽 ¹ , 王唱 ¹ , 滕汝枫 ¹ , 卜雯钰 ¹ , 顾汉程 ² , 曹建春 ²^,^*

中医药学报 | 学术探讨 2026,54(10): 1-6

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中医药学报 |学术探讨 2026 , 54 (10) : 1 -6

从线粒体生物发生与自噬机制探讨益气活血法促进糖尿病足溃疡愈合的科学内涵

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常金霞¹, 杨俏丽¹, 王唱¹, 滕汝枫¹, 卜雯钰¹, 顾汉程², 曹建春²^,^*

作者信息

^1.北京中医药大学，北京　100029

^2.北京中医药大学东方医院，北京　100078

通讯作者:

^* 曹建春（1972-），男，博士，主任医师，研究方向：中西医结合治疗周围血管病。

作者简介:

常金霞（1996-），女，博士研究生，研究方向：中西医结合治疗周围血管病。

Exploration on the Scientific Connotation of the “Tonifying Qi and Activating Blood” Method in Promoting Diabetic Foot Ulcer Healing from the Perspective of Mitochondrial Biogenesis and Autophagy Mechanisms

Jinxia CHANG¹, Qiaoli YANG¹, Chang WANG¹, Rufeng TENG¹, Wenyu BU¹, Hancheng GU², Jianchun CAO²^,^*

Affiliations

^1.Beijing University of Chinese Medicine, Beijing 100029, China

^2.Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China

出版时间: 2026-10-20 doi: 10.19664/j.cnki.1002-2392.260194

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摘要

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本研究基于糖尿病足溃疡（DFU）中医气虚血瘀核心病机，从线粒体生物发生与自噬协同调控失衡的微观机制，深度阐释DFU“气虚为本，致能量代谢障碍；血瘀为标，致病理产物蓄积”的中医病机本质。气虚的本质为线粒体生物发生障碍导致的功能性线粒体不足、氧化磷酸化受阻、ATP合成减少，形成“低新生”的创面环境；血瘀的本质为线粒体自噬缺陷、损伤线粒体、线粒体活性氧等毒性代谢产物清除障碍，形成“高瘀阻”的慢性炎症微环境。二者互结形成恶性循环，共同阻滞创面修复进程。益气法调控线粒体生物发生，活血法调控线粒体自噬，二者协同打破线粒体质量控制失衡循环，为益气活血法通过重塑线粒体稳态，促进创面修复提供了科学依据，为中西医结合防治DFU提供了新理论支点。

关键词

糖尿病足溃疡 / 线粒体生物发生 / 线粒体自噬 / 气虚血瘀 / 益气活血

Abstract

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Based on the traditional Chinese medicine (TCM) pathogenesis of “Qi-deficiency and blood-stasis” in diabetic foot ulcer (DFU), this study elucidates the microscopic mechanism underlying DFU from the perspective of dysregulated coordination between mitochondrial biogenesis and mitophagy. We propose that qi-deficiency corresponds to insufficient functional mitochondria caused by impaired biogenesis, resulting in compromised oxidative phosphorylation and reduced ATP production, thereby generating a “low-renewal” wound milieu. Blood-stasis is defined as the failure to eliminate damaged mitochondria and toxic metabolites such as mtROS due to defective mitophagy, establishing a “high-stasis” chronic inflammatory microenvironment. These two processes mutually reinforce each other, forming a vicious cycle that impedes wound healing. Tonifying Qi enhances mitochondrial biogenesis, whereas activating blood resolves stasis by restoring mitophagy; their synergism disrupts the cycle of mitochondrial quality-control imbalance. This mechanism provides a scientific rationale for the TCM strategy of “tonifying qi and activating blood” in re-establishing mitochondrial homeostasis and promoting DFU repair, offering a novel theoretical basis for integrated Chinese-Western management of DFU.

Key words

Diabetic foot ulcer (DFU) / Mitochondrial biogenesis / Mitophagy / Qi-deficiency and blood-stasis / Tonifying qi and activating blood

引用本文

常金霞, 杨俏丽, 王唱, 滕汝枫, 卜雯钰, 顾汉程, 曹建春. 从线粒体生物发生与自噬机制探讨益气活血法促进糖尿病足溃疡愈合的科学内涵. 中医药学报, 2026 , 54 (10) : 1 -6 . DOI: 10.19664/j.cnki.1002-2392.260194

Jinxia CHANG, Qiaoli YANG, Chang WANG, Rufeng TENG, Wenyu BU, Hancheng GU, Jianchun CAO. Exploration on the Scientific Connotation of the “Tonifying Qi and Activating Blood” Method in Promoting Diabetic Foot Ulcer Healing from the Perspective of Mitochondrial Biogenesis and Autophagy Mechanisms[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (10) : 1 -6 . DOI: 10.19664/j.cnki.1002-2392.260194

基金

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国家自然科学基金面上项目(8187151877)
北京中医药大学研究生自主科研课题(ZJKT2025021)
中央高水平中医医院临床科研业务费资助项目(DFGZRB-2024GJRC016)

参考文献

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2026年第54卷第10期

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文章信息

doi: 10.19664/j.cnki.1002-2392.260194

接收时间：2025-07-21
首发时间：2026-10-14
出版时间：2026-10-20

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出版历史

收稿日期：2025-07-21
修回日期：2026-04-24

基金

国家自然科学基金面上项目(8187151877)

北京中医药大学研究生自主科研课题(ZJKT2025021)

中央高水平中医医院临床科研业务费资助项目(DFGZRB-2024GJRC016)

作者信息

^1.北京中医药大学，北京　100029

^2.北京中医药大学东方医院，北京　100078

通讯作者:

^* 曹建春（1972-），男，博士，主任医师，研究方向：中西医结合治疗周围血管病。

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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