Article(id=1305171238654071395, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260191, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1750953600000, receivedDateStr=2025-06-27, revisedDate=1778774400000, revisedDateStr=2026-05-15, acceptedDate=null, acceptedDateStr=null, onlineDate=1789106672204, onlineDateStr=2026-09-11, pubDate=1789833600000, pubDateStr=2026-09-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789106672204, onlineIssueDateStr=2026-09-11, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789106672204, creator=13701087609, updateTime=1789106672204, updator=13701087609, issue=Issue{id=1305171206701871960, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='9', pageStart='1', pageEnd='133', issueExtLink='null', onlineDate='null', pubDate='1789833600000', pubDateStr='2026-09-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1789106664586, creator='13701087609', updateTime=1789106805687, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1305171798593663109, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1305171798593663110, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=116, endPage=120, ext={EN=ArticleExt(id=1305171238805066340, articleId=1305171238654071395, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effects of Banxia Xiexin Decoction on Immune and Nutritional Status in Patients with Locally Advanced Gastric Cancer Receiving Postoperative SOX Regimen Chemotherapy, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore and analyze the application effect of Banxia Xiexin Decoction on patients with locally advanced gastric cancer during postoperative SOX regimen chemotherapy, and to analyze its influence on immunity and nutritional status of patients.
Methods: A total of 118 patients with locally advanced gastric cancer who visited department of gastrointestinal surgery of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from May 2021 to May 2024 were included. They were randomly divided into the conventional group and the combined group using a random number table (simple random grouping method), with 59 cases in each group. The patients in the conventional group received SOX regimen chemotherapy after surgery, whereas the patients in the combined group were added with Banxia Xiexin Decoction. The changes of tumor factors, immune factors, gastrointestinal function and nutritional indicators were observed in the two groups after treatment.
Results: After treatment, the levels of carcinoembryonic antigen, vascular endothelial growth factor, matrix metalloproteinase-9 and other tumor factors in the combined group were lower than those in the conventional group (P < 0.05). The levels of diamine oxidase and fecal calprotectin in the combined group were lower while the level of motilin was higher compared to the conventional group (P <0.05). The neutrophil-to-lymphocyte ratio and interleukin-6 in the combined group were lower compared with those in the conventional group while the proportion of CD8 + T was higher (P <0.05). The levels of albumin, prealbumin and transferrin and body mass in the combined group were higher than those in the conventional group (P <0.05). In terms of treatment safety, the incidence rates of adverse chemotherapy reactions were lower in the combined group compared to the conventional group (P <0.05).
Conclusion: Banxia Xiexin Decoction can reduce the levels of tumor factors, promote the improvements of gastrointestinal function, immunity and nutritional status, and play a role in reducing toxicity and increasing efficiency in patients with locally advanced gastric cancer receiving SOX regimen chemotherapy after surgery.
, authors=Jian HU, Hangjun GONG, Gang HAN, Yu CAO, Yun ZHANG, Yanyan ZHANG, Xu ZHANG, authorsList=Jian HU, Hangjun GONG, Gang HAN, Yu CAO, Yun ZHANG, Yanyan ZHANG, Xu ZHANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1305171239119639141, articleId=1305171238654071395, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=半夏泻心汤对局部进展期胃癌术后SOX方案化疗患者免疫及营养状态的影响, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探析中药方剂半夏泻心汤在局部进展期胃癌患者术后接受SOX方案化疗中的应用效果，并分析其对患者免疫、营养状态的影响。
方法： 纳入2021年5月—2024年5月在上海中医药大学附属曙光医院胃肠外科就诊的118例局部进展期胃癌患者，利用随机数字表随机（简单随机分组法）均分为常规组和联合组，每组59例。常规组患者在接受手术后给予SOX方案化疗，联合组则加用半夏泻心汤治疗，观察治疗后两组肿瘤因子、免疫因子、胃肠道功能及营养指标的变化。
结果： 治疗后，联合组癌胚抗原、血管内皮生长因子、金属基质蛋白酶-9等肿瘤因子水平低于常规组（P < 0.05）；联合组二胺氧化酶、粪钙卫蛋白水平低于常规组，胃动素水平高于常规组（P < 0.05）；联合组中性粒细胞与淋巴细胞比值、白介素-6水平低于常规组，CD8+T比例高于常规组（P < 0.05）；联合组白蛋白、前白蛋白、转铁蛋白水平及体质量高于常规组（P < 0.05）；在治疗安全性方面，联合组化疗不良反应发生率低于常规组（P < 0.05）。
结论： 局部进展期胃癌患者术后接受SOX方案化疗应用半夏泻心汤能降低肿瘤因子水平，促进胃肠道功能、免疫和营养状态改善，发挥减毒增效的作用。
, authors=胡建, 龚航军, 韩刚, 曹羽, 张云, 张言言, 张旭, authorsList=胡建, 龚航军, 韩刚, 曹羽, 张云, 张言言, 张旭, authorCompany=null, correspAuthors=null, authorNote=
胡建（1993-），男，硕士，主治医师，主要从事胃肠道肿瘤综合治疗相关研究。
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胡建（1993-），男，硕士，主治医师，主要从事胃肠道肿瘤综合治疗相关研究。
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胡建（1993-），男，硕士，主治医师，主要从事胃肠道肿瘤综合治疗相关研究。
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