Article(id=1305171243708207767, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260189, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756915200000, receivedDateStr=2025-09-04, revisedDate=1779120000000, revisedDateStr=2026-05-19, acceptedDate=null, acceptedDateStr=null, onlineDate=1789106673408, onlineDateStr=2026-09-11, pubDate=1789833600000, pubDateStr=2026-09-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789106673408, onlineIssueDateStr=2026-09-11, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789106673408, creator=13701087609, updateTime=1789106673408, updator=13701087609, issue=Issue{id=1305171206701871960, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='9', pageStart='1', pageEnd='133', issueExtLink='null', onlineDate='null', pubDate='1789833600000', pubDateStr='2026-09-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1789106664586, creator='13701087609', updateTime=1789106805687, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1305171798593663109, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1305171798593663110, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=104, endPage=110, ext={EN=ArticleExt(id=1305171244022780568, articleId=1305171243708207767, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Efficacy of External Application of Zihua Shengji Formula on Postoperative Wounds in Anorectal Department Based on the Theory of "Fostering Exudate to Promote Tissue Regeneration", columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To analyze the efficacy of external application of Zihua Shengji Formula (Purple Flower Tissue Regeneration Formula) on postoperative wounds in anorectal surgery based on the theory of "Fostering exudate to promote tissue regeneration" Theory.
Methods: A total of 120 patients with low simple anal fistula/external haemorrhoid undergoing surgery in the Anorectal Department of Handan Hospital of Traditional Chinese Medicine from November 2023 to November 2024 were selected as the study subjects. Patients were numbered 1-120 according to their visit sequence and randomly divided into a control group (60 cases, receiving routine postoperative wound care with Western medicine) and a study group (60 cases, receiving routine postoperative wound care with Western medicine plus external application of Zihua Shengji Formula). The wound healing status, wound pain level, inflammatory cytokine levels in wound tissue, growth factor levels, and extracellular matrix (ECM) metabolism-related indicators were compared between the two groups.
Results: Compared with the control group, the study group showed significantly higher wound healing rates on the 7th and 14th postoperative days, significantly lower Visual Analogue Scale (VAS) pain scores on the 7th and 14th postoperative days, and a significantly shorter wound healing time (P <0.05). Compared with levels on the 1st postoperative day within each group, the levels of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 in wound tissue on the 14th postoperative day decreased significantly in both groups, while IL-10 levels increased significantly. Furthermore, compared with the control group, the study group exhibited significantly lower levels of TNF-α, IL-1β, and IL-6, and significantly higher levels of IL-10 on the 14th postoperative day (P < 0.05). Compared with levels on the 1st postoperative day within each group, the levels of platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) in wound tissue on the 14th postoperative day increased significantly in both groups. Additionally, compared with the control group, the study group showed significantly higher levels of PDGF, VEGF, and bFGF on the 14th postoperative day (P < 0.05). Compared with levels on the 1st postoperative day within each group, the levels of matrix metalloproteinase-2 (MMP-2) in wound tissue on the 14th postoperative day decreased significantly in both groups, while type I collagen (Col I) levels increased significantly. Moreover, compared with the control group, the study group had significantly lower levels of MMP-2 and significantly higher levels of Col I on the 14th postoperative day (P < 0.05).
Conclusion: External application of Zihua Shengji Formula facilitates the reduction of postoperative pain and wound inflammation in anorectal surgery patients. It regulates the levels of wound growth factors and ECM metabolism-related indicators, promotes wound repair, and shortens wound healing time.
, authors=Jianfeng LI, Xin SONG, Xiaosa SUN, Zhida ZHANG, Zhaozhao LI, authorsList=Jianfeng LI, Xin SONG, Xiaosa SUN, Zhida ZHANG, Zhaozhao LI, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1305171244333159065, articleId=1305171243708207767, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于“煨脓长肉”理论分析紫花生肌方外敷对肛肠科术后创面的疗效, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 基于“煨脓长肉”理论分析紫花生肌方外敷对肛肠科术后创面的疗效。
方法： 选取2023年11月—2024年11月于邯郸市中医院肛肠科行手术治疗的120例低位单纯性肛瘘/外痔患者作为研究对象，依据随机数字表法分为对照组（60例，术后创面采用常规西医处理）与研究组（60例，术后创面采用常规西医处理+紫花生肌方外敷），对比两组创面修复情况、创面疼痛程度、创面组织炎症因子、生长因子及细胞外基质（ECM）代谢相关指标水平。
结果： 与对照组比较，研究组术后第7天及术后第14天创面愈合率均较高，创面疼痛VAS评分均较低，创面愈合时间较短（P < 0.01）；与本组术后第1天比较，两组术后第14天创面组织肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1β、IL-6水平均降低，IL-10水平均提高（P < 0.05），且与对照组比较，研究组TNF-α、IL-1β、IL-6水平较低，IL-10水平较高（P < 0.05）；与本组术后第1天比较，两组术后第14天创面组织血小板源性生长因子（PDGF）、血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）水平均提高，且与对照组比较，研究组PDGF、VEGF、bFGF水平均较高（P < 0.05）；与本组术后第1天比较，两组术后第14天创面组织基质金属蛋白酶-2（MMP-2）水平均降低，Ⅰ型胶原蛋白（ColⅠ）水平均提高，且与对照组比较，研究组MMP-2水平较低（P < 0.05），ColⅠ水平均较高（P < 0.05）。
结论： 紫花生肌方外敷利于减轻肛肠科患者术后疼痛及创面炎症反应，调节创面生长因子、ECM代谢相关指标水平，促进创面修复，缩短创面愈合时间。
, authors=李建锋, 宋欣, 孙潇洒, 张智达, 李召召, authorsList=李建锋, 宋欣, 孙潇洒, 张智达, 李召召, authorCompany=null, correspAuthors=null, authorNote=
李建锋（1979-），男，副主任医师，从事中医临床相关研究。
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李建锋（1979-），男，副主任医师，从事中医临床相关研究。
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李建锋（1979-），男，副主任医师，从事中医临床相关研究。
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