Article(id=1305171237265764410, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260188, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753372800000, receivedDateStr=2025-07-25, revisedDate=1779120000000, revisedDateStr=2026-05-19, acceptedDate=null, acceptedDateStr=null, onlineDate=1789106671872, onlineDateStr=2026-09-11, pubDate=1789833600000, pubDateStr=2026-09-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789106671872, onlineIssueDateStr=2026-09-11, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789106671872, creator=13701087609, updateTime=1789106671872, updator=13701087609, issue=Issue{id=1305171206701871960, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='9', pageStart='1', pageEnd='133', issueExtLink='null', onlineDate='null', pubDate='1789833600000', pubDateStr='2026-09-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1789106664586, creator='13701087609', updateTime=1789106805687, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1305171798593663109, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1305171798593663110, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=99, endPage=103, ext={EN=ArticleExt(id=1305171237509034043, articleId=1305171237265764410, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Efficacy and Mechanism of Modified Baihu Guizhi Decoction Combined with Methotrexate in the Treatment of Rheumatoid Arthritis, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the clinical efficacy of modified Baihu Guizhi Decoction combined with methotrexate (MTX) in the treatment of rheumatoid arthritis (RA)

Methods

A randomized controlled trial was conducted. A total of 120 RA patients admitted to the outpatient and inpatient departments of Rheumatology and Immunology at Xinyang Central Hospital from January 2022 to April 2024 were randomly divided into a control group and an observation group, with 60 cases in each group. The control group received standard-dose MTX, while the observation group received modified Baihu Guizhi Decoction in addition to the MTX regimen. The treatment duration was 12 weeks. Traditional Chinese medicine (TCM) syndrome scores, Visual Analog Scale (VAS) scores, joint swelling degree, morning stiffness duration, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF) titer, C-reactive protein (CRP), and macrophage migration inhibitory factor (MIF) levels were compared between the two groups before and after treatment to evaluate efficacy and safety.

Results

After treatment, TCM syndrome scores, VAS scores, morning stiffness duration, and joint swelling degree improved in both groups, and ESR, RF, CRP, and MIF levels decreased (P < 0.05). The observation group showed significantly greater improvements compared to the control group (P <0.05). The proportion of patients achieving ACR50/70 improvement criteria was higher (P < 0.05), and the incidence of adverse reactions was lower (P < 0.05) in the observation group.

Conclusion

Modified Baihu Guizhi Decoction combined with MTX demonstrates significant efficacy in treating RA with Wind-Damp-Heat obstruction syndrome. Its mechanism of action may be related to the regulation of CRP and MIF expression.

, authors=Sheng ZHANG1, Qiankun ZHANG1, Manyi LI2, authorsList=Sheng ZHANG, Qiankun ZHANG, Manyi LI, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1305171237869744188, articleId=1305171237265764410, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=白虎加桂枝汤加减方联合甲氨蝶呤治疗类风湿性关节炎的疗效及机制研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的:

探讨白虎加桂枝汤加减方联合甲氨蝶呤(MTX)治疗类风湿性关节炎(RA)的临床疗效。

方法:

采用随机对照试验设计,选取2022年1月—2024年4月信阳市中心医院风湿免疫科门诊及住院收治的RA患者120例,随机分为对照组和观察组,每组60例。对照组给予MTX标准剂量治疗;观察组在对照组基础上联合使用白虎加桂枝汤加减方,治疗周期为12周。对比两组治疗前后中医证候积分、视觉模拟量表(VAS)、关节肿胀程度、晨僵时间、红细胞沉降率(ESR)、类风湿因子(RF)滴度、C反应蛋白(CRP)、巨噬细胞移动抑制因子(MIF)水平,评估其疗效及安全性。

结果:

治疗后,两组中医证候积分、VAS评分、晨僵时间、关节肿胀程度均改善,ESR、RF、CRP、MIF水平均下降(P < 0.05,P < 0.01),其中观察组变化更优(P < 0.05,P < 0.01)。观察组达到ACR50/70改善标准的比例更高(P < 0.05,P <0.01),不良反应发生率更低(P < 0.05)。

结论:

白虎加桂枝汤加减方联合MTX治疗RA风湿热痹证疗效显著,其作用机制可能与调节CRP、MIF表达有关。

, authors=张晟1, 张乾坤1, 李满意2, authorsList=张晟, 张乾坤, 李满意, authorCompany=null, correspAuthors=null, authorNote=

张晟(1984-),男,硕士,副主任中医师,从事风湿免疫病的中西结合治疗相关研究。

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张晟(1984-),男,硕士,副主任中医师,从事风湿免疫病的中西结合治疗相关研究。

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张晟(1984-),男,硕士,副主任中医师,从事风湿免疫病的中西结合治疗相关研究。

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白虎加桂枝汤加减方联合甲氨蝶呤治疗类风湿性关节炎的疗效及机制研究
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张晟 1 , 张乾坤 1 , 李满意 2
中医药学报 | 临床研究 2026,54(9): 99-103
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中医药学报 |临床研究 2026 , 54 (9) : 99 -103
白虎加桂枝汤加减方联合甲氨蝶呤治疗类风湿性关节炎的疗效及机制研究
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张晟1, 张乾坤1, 李满意2
作者信息
  • 1.信阳市中心医院,河南 信阳 464000
  • 2.河南风湿病医院,河南 郑州 450044
作者简介:

张晟(1984-),男,硕士,副主任中医师,从事风湿免疫病的中西结合治疗相关研究。

Efficacy and Mechanism of Modified Baihu Guizhi Decoction Combined with Methotrexate in the Treatment of Rheumatoid Arthritis
Sheng ZHANG1, Qiankun ZHANG1, Manyi LI2
Affiliations
  • 1.Xinyang Central Hospital, Xinyang 464000, China
  • 2.Henan Rheumatism Hospital, Zhengzhou 450044, China
出版时间: 2026-09-20 doi: 10.19664/j.cnki.1002-2392.260188
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目的:

探讨白虎加桂枝汤加减方联合甲氨蝶呤(MTX)治疗类风湿性关节炎(RA)的临床疗效。

方法:

采用随机对照试验设计,选取2022年1月—2024年4月信阳市中心医院风湿免疫科门诊及住院收治的RA患者120例,随机分为对照组和观察组,每组60例。对照组给予MTX标准剂量治疗;观察组在对照组基础上联合使用白虎加桂枝汤加减方,治疗周期为12周。对比两组治疗前后中医证候积分、视觉模拟量表(VAS)、关节肿胀程度、晨僵时间、红细胞沉降率(ESR)、类风湿因子(RF)滴度、C反应蛋白(CRP)、巨噬细胞移动抑制因子(MIF)水平,评估其疗效及安全性。

结果:

治疗后,两组中医证候积分、VAS评分、晨僵时间、关节肿胀程度均改善,ESR、RF、CRP、MIF水平均下降(P < 0.05,P < 0.01),其中观察组变化更优(P < 0.05,P < 0.01)。观察组达到ACR50/70改善标准的比例更高(P < 0.05,P <0.01),不良反应发生率更低(P < 0.05)。

结论:

白虎加桂枝汤加减方联合MTX治疗RA风湿热痹证疗效显著,其作用机制可能与调节CRP、MIF表达有关。

白虎加桂枝汤加减方  /  甲氨蝶呤  /  类风湿性关节炎  /  风湿热痹证  /  临床疗效
Objective

To investigate the clinical efficacy of modified Baihu Guizhi Decoction combined with methotrexate (MTX) in the treatment of rheumatoid arthritis (RA)

Methods

A randomized controlled trial was conducted. A total of 120 RA patients admitted to the outpatient and inpatient departments of Rheumatology and Immunology at Xinyang Central Hospital from January 2022 to April 2024 were randomly divided into a control group and an observation group, with 60 cases in each group. The control group received standard-dose MTX, while the observation group received modified Baihu Guizhi Decoction in addition to the MTX regimen. The treatment duration was 12 weeks. Traditional Chinese medicine (TCM) syndrome scores, Visual Analog Scale (VAS) scores, joint swelling degree, morning stiffness duration, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF) titer, C-reactive protein (CRP), and macrophage migration inhibitory factor (MIF) levels were compared between the two groups before and after treatment to evaluate efficacy and safety.

Results

After treatment, TCM syndrome scores, VAS scores, morning stiffness duration, and joint swelling degree improved in both groups, and ESR, RF, CRP, and MIF levels decreased (P < 0.05). The observation group showed significantly greater improvements compared to the control group (P <0.05). The proportion of patients achieving ACR50/70 improvement criteria was higher (P < 0.05), and the incidence of adverse reactions was lower (P < 0.05) in the observation group.

Conclusion

Modified Baihu Guizhi Decoction combined with MTX demonstrates significant efficacy in treating RA with Wind-Damp-Heat obstruction syndrome. Its mechanism of action may be related to the regulation of CRP and MIF expression.

Modified Baihu Guizhi Decoction  /  Methotrexate  /  Rheumatoid arthritis  /  Wind-Damp-Heat obstruction syndrome  /  Clinical efficacy
张晟, 张乾坤, 李满意. 白虎加桂枝汤加减方联合甲氨蝶呤治疗类风湿性关节炎的疗效及机制研究. 中医药学报, 2026 , 54 (9) : 99 -103 . DOI: 10.19664/j.cnki.1002-2392.260188
Sheng ZHANG, Qiankun ZHANG, Manyi LI. Efficacy and Mechanism of Modified Baihu Guizhi Decoction Combined with Methotrexate in the Treatment of Rheumatoid Arthritis[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (9) : 99 -103 . DOI: 10.19664/j.cnki.1002-2392.260188
  • 河南省中医药科学研究专项课题(20-21ZY3042)
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doi: 10.19664/j.cnki.1002-2392.260188
  • 接收时间:2025-07-25
  • 首发时间:2026-09-11
  • 出版时间:2026-09-20
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  • 收稿日期:2025-07-25
  • 修回日期:2026-05-19
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河南省中医药科学研究专项课题(20-21ZY3042)
作者信息
    1.信阳市中心医院,河南 信阳 464000
    2.河南风湿病医院,河南 郑州 450044
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2种不同金属材料的力学参数

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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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