Article(id=1305171226129888231, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260186, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1742832000000, receivedDateStr=2025-03-25, revisedDate=1766419200000, revisedDateStr=2025-12-23, acceptedDate=null, acceptedDateStr=null, onlineDate=1789106669217, onlineDateStr=2026-09-11, pubDate=1789833600000, pubDateStr=2026-09-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789106669217, onlineIssueDateStr=2026-09-11, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789106669217, creator=13701087609, updateTime=1789106669217, updator=13701087609, issue=Issue{id=1305171206701871960, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='9', pageStart='1', pageEnd='133', issueExtLink='null', onlineDate='null', pubDate='1789833600000', pubDateStr='2026-09-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1789106664586, creator='13701087609', updateTime=1789106805687, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1305171798593663109, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1305171798593663110, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1305171206701871960, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=86, endPage=93, ext={EN=ArticleExt(id=1305171226268300264, articleId=1305171226129888231, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Study on the Effects of Comprehensive Traditional Chinese Medicine Therapy Based on the Theory of Simultaneous Treatment of the Lung, Spleen, and Kidney on Th1/Th2 Balance and Airway Remodeling in Patients with Stable Chronic Obstructive Pulmonary Disease, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the impact of traditional Chinese medicine (TCM) comprehensive therapy, grounded in the theoretical framework of lung, spleen, and kidney treatment, on the balance of Th1/Th2 cytokines and airway remodeling in patients with stable chronic obstructive pulmonary disease (COPD).
Methods: A total of 180 patients with stable COPD who attended the hospital between March 2023 and December 2024 were selected as study participants. A total of 180 patients with stable chronic obstructive pulmonary disease (COPD) who were treated at our hospital between January 2022 and September 2023 were recruited as research participants. These patients were allocated into four groups: the Traditional Chinese Medicine (TCM) group (n = 60), which received basic Western medicine treatment combined with a TCM formula for replenishing qi, dredging collaterals, strengthening the spleen, and tonifying the kidney; the Acupoint group (n = 60), which received basic Western medicine treatment combined with acupoint application therapy; the Combined group (n = 60), which received basic Western medicine treatment combined with both the TCM formula and acupoint application therapy. Data collection included pulmonary function indices [forced vital capacity (FVC), forced expiratory volume in the first second (FEV1)], COPD Assessment Test (CAT) scores, modified British Medical Research Council dyspnea questionnaire (mMRC) scores, serum interferon-γ (IFN-γ), and interleukin-4 (IL-4) levels. Additionally, the study evaluated the ratio of airway wall thickness to external diameter (T/D), the percentage of airway wall thickness relative to total airway diameter (WA%), airway smooth muscle area (ASM%), emphysema index (LAA%), and the incidence of adverse reactions.
Results: The total efficacy rate in the combined treatment group was 100.00% (60/60), which was significantly higher than that in the TCM group (86.67%, 52/60) and the acupoint therapy group (88.33%, 53/60) (86.67%) and the acupoint therapy group (88.33%) (P < 0.05). No significant difference was observed in the total clinical effective rate between the Chinese Medicine group and the Acupoint Therapy group (P > 0.05). After 9 months of treatment, there were no significant differences in serum IFN-γ, IL-4 levels or the IFN-γ/IL-4 ratio between the Chinese medicine group and the acupoint therapy group (P >0.05). At the 9-month mark, serum IFN-γ levels and the IFN-γ/IL-4 ratio in the Combined Therapy group were significantly higher than those in both the Chinese Medicine group and the Acupoint Therapy group (P < 0.05). At the 9-month mark, serum IL-4 levels in the Combined Therapy group were significantly lower than those in both the Chinese Medicine group and the Acupoint Therapy group (P < 0.05). At 3, 6, and 9 months of treatment, the T/D, WA, ASM, and LAA values in the combined treatment group were significantly lower than those in the Chinese medicine group and the acupoint therapy group (P <0.05). At 3, 6, and 9 months of treatment, there were no significant differences in T/D, WA, ASM, or LAA values between the Chinese medicine group and the acupoint therapy group (P >0.05). No significant difference in clinical efficacy was observed between the TCM group and the acupoint therapy group (P >0.05). Post-treatment analysis revealed no significant differences in serum IFN-γ and IL-4 levels, the IFN-γ/IL-4 ratio, as well as T/D, WA, ASM, and LAA values between the TCM group and the acupoint therapy group (P > 0.05). In contrast, the combined treatment group exhibited significantly higher post-treatment serum IFN-γ levels and IFN-γ/IL-4 ratios compared to both the TCM and acupoint therapy groups (P <0.05). Additionally, the combined treatment group demonstrated significantly lower post-treatment serum IL-4 levels and T/D, WA, ASM, and LAA values compared to the TCM and acupoint therapy groups (P < 0.05). The incidence of adverse reactions in the three groups was 15.00%, 16.67%, and 5.00%, respectively, with no statistically significant differences observed among the groups (P > 0.05).
Conclusion: Traditional Chinese medicine comprehensive therapy, grounded in the theoretical framework of lung, spleen, and kidney treatment, can regulate the Th1/Th2 immune balance via multiple targets and inhibit airway remodeling. This approach effectively enhances lung function and alleviates clinical symptoms in patients with stable COPD. It demonstrates significant advantages in terms of efficacy stability and safety, thereby exhibiting high application value.
, authors=Yuanyuan XIN, Jing LUO, Shengli YUAN, Henan XIAO, Meng CUI, authorsList=Yuanyuan XIN, Jing LUO, Shengli YUAN, Henan XIAO, Meng CUI, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1305171226591261673, articleId=1305171226129888231, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于肺脾肾同治理论的中医综合疗法对慢性阻塞性肺疾病稳定期患者Th1/Th2平衡及气道重塑的影响研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探究基于肺脾肾同治理论的中医综合疗法对慢性阻塞性肺疾病（COPD）稳定期患者Th1/Th2平衡及气道重塑的影响。
方法： 选取2023年3月—2024年12月于张家口市中医院就诊的COPD稳定期患者180例，采用随机数字表法分为中药组60例（基础西医治疗+益气通络、健脾补肾方加减），穴位组60例（基础西医治疗+穴位贴敷），联合组60例（基础西医治疗+益气通络、健脾补肾方加减 +穴位贴敷），检测3组肺功能指标［用力肺活量（FVC）、第一秒用力呼气容积（FEV1）］水平，COPD患者自我评估测试（CAT）评分，改良版英国医学研究委员会呼吸困难问卷（mMRC）评分，血清干扰素-γ（IFN-γ）、白细胞介素-4（IL-4）水平，气道壁厚度与外径比值（T/D），气道壁厚度/总气道直径比（WA），气道平滑肌面积（ASM），肺气肿指数（LAA）及不良反应发生率，评估临床整体效果。
结果： 联合组治疗总有效率达100.00% （60/60），分别高于中药组的86.67% （52/60）和穴位组的88.33% （53/60），差异有统计学意义（P < 0.05）；中药组临床总有效率与穴位组比较，差异无统计学意义（P > 0.05）；治疗9个月，中药组患者血清IFN-γ、IL-4水平及IFN-γ/IL-4比值与穴位组比较，差异无统计学意义（P > 0.05）；治疗9个月，联合组血清IFN-γ水平及IFN-γ/IL-4比值分别高于中药组和穴位组（P <0.05）；治疗9个月，联合组血清IL-4水平分别低于中药组和穴位组（P < 0.05）；治疗3个月、6个月、9个月联合组T/D、WA、ASM、LAA值低于中药组和穴位组（P < 0.05）；治疗3个月、6个月、9个月中药组患者T/D、WA、ASM、LAA值与穴位组比较，差异无统计学意义（P > 0.05）。3组患者不良反应发生率分别为15.00% （1/60）、16.67% （10/60）、5.00% （3/60），组间比较差异无统计学意义（P > 0.05）。
结论： 基于肺脾肾同治理论的中医综合疗法可通过多靶点调节Th1/Th2免疫平衡，抑制气道重塑进程，从而显著改善COPD稳定期患者的肺功能及临床症状，在疗效稳定性、安全性方面具较大优势，应用价值颇高。
, authors=辛元元, 罗静, 袁胜利, 肖赫男, 崔朦, authorsList=辛元元, 罗静, 袁胜利, 肖赫男, 崔朦, authorCompany=null, correspAuthors=null, authorNote=
辛元元（1991-），女，硕士，主治中医师，从事中医内科学相关研究。
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