Article(id=1307264638635242099, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307264617252680149, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260171, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1741968000000, receivedDateStr=2025-03-15, revisedDate=1760976000000, revisedDateStr=2025-10-21, acceptedDate=null, acceptedDateStr=null, onlineDate=1789605777652, onlineDateStr=2026-09-17, pubDate=1787155200000, pubDateStr=2026-08-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789605777652, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789605777652, creator=13701087609, updateTime=1789605777652, updator=13701087609, issue=Issue{id=1307264617252680149, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='8', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1787155200000', pubDateStr='2026-08-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789605772555, creator='13701087609', updateTime=1789605772555, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=119, endPage=128, ext={EN=ArticleExt(id=1307264638794625652, articleId=1307264638635242099, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Research Progress on Regulating Metabolic Reprogramming with Traditional Chinese Medicine to Improve Ovarian Aging, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Ovarian aging is an important factor causing female infertility, and its pathogenesis is complex. Currently, the use of hormone replacement therapy has limitations. Therefore, in-depth exploration of the pathogenesis of ovarian aging and seeking safe and effective treatment methods have great clinical application value. Metabolic reprogramming plays an important role in the growth, development, and maturation of oocytes, and its abnormalities can accelerate ovarian aging by activating related signaling pathways and regulating the expression of apoptosis related proteins. In recent years, research on the regulation of metabolic reprogramming by traditional Chinese medicine to delay ovarian aging has made certain progress. This article summarizes and analyzes the metabolic reprogramming abnormalities in sugar, lipid, amino acid, and immune metabolism during ovarian aging, and summarizes the relevant studies on the regulation of these core metabolic links by traditional Chinese medicine extracts and formulas to delay the process of ovarian aging. The aim is to provide new clinical treatment ideas for delaying ovarian aging and improving female fertility from the perspective of regulating metabolic reprogramming by traditional Chinese medicine.

, authors=Wenlong QI1, Zhicheng JIA2, Yongqian LI1, Peixuan WANG1, Mengyu SHI1, Xinxin YANG1, Xinwei SUN1, Ying GUO1, 3, *, authorsList=Wenlong QI, Zhicheng JIA, Yongqian LI, Peixuan WANG, Mengyu SHI, Xinxin YANG, Xinwei SUN, Ying GUO, authorCompany=null, correspAuthors=Ying GUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307264639138558581, articleId=1307264638635242099, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=中医药调控代谢重编程改善卵巢衰老的研究进展, columnId=1303760941036888710, journalTitle=中医药学报, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

卵巢衰老是造成女性不孕的重要因素,其发病机制复杂,目前采用激素替代疗法存在局限性,因此深入探索卵巢衰老的发病机制,寻求安全有效的治疗方法极具临床应用价值。代谢重编程在卵母细胞生长、发育和成熟过程中发挥重要作用,其异常可通过激活相关信号通路和调控凋亡相关蛋白的表达,加速卵巢衰老进程。近年来,中医药调控代谢重编程延缓卵巢衰老的研究取得了一定进展,本文汇总分析了卵巢衰老过程中糖、脂质、氨基酸及免疫代谢等方面的代谢重编程异常,并对中药提取物和中药复方调控这些核心代谢环节的重编程异常,从而延缓卵巢衰老进程的相关研究进行归纳总结,以期从中医药调控代谢重编程角度,为延缓卵巢衰老、提高女性生育能力提供新的临床治疗思路。

, authors=亓文隆1, 贾志诚2, 李永谦1, 王培璇1, 石梦雨1, 杨鑫鑫1, 孙昕玮1, 郭颖1, 3, *, authorsList=亓文隆, 贾志诚, 李永谦, 王培璇, 石梦雨, 杨鑫鑫, 孙昕玮, 郭颖, authorCompany=null, correspAuthors=郭颖, authorNote=

亓文隆(2000-),男,硕士研究生,从事中医药在辅助生殖领域的相关研究。

, correspAuthorsNote=
* 郭颖(1983-),女,博士,主任医师,从事中医药在辅助生殖领域的相关研究。
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亓文隆(2000-),男,硕士研究生,从事中医药在辅助生殖领域的相关研究。

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亓文隆(2000-),男,硕士研究生,从事中医药在辅助生殖领域的相关研究。

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中医药调控代谢重编程改善卵巢衰老的研究进展
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亓文隆 1 , 贾志诚 2 , 李永谦 1 , 王培璇 1 , 石梦雨 1 , 杨鑫鑫 1 , 孙昕玮 1 , 郭颖 1, 3, *
中医药学报 | 研究进展 2026,54(8): 119-128
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中医药学报 |研究进展 2026 , 54 (8) : 119 -128
中医药调控代谢重编程改善卵巢衰老的研究进展
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亓文隆(2000-),男,硕士研究生,从事中医药在辅助生殖领域的相关研究。

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亓文隆(2000-),男,硕士研究生,从事中医药在辅助生殖领域的相关研究。

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亓文隆1, 贾志诚2, 李永谦1, 王培璇1, 石梦雨1, 杨鑫鑫1, 孙昕玮1, 郭颖1, 3, *
作者信息
  • 1.山东中医药大学,山东 济南 250014
  • 2.中国中医科学院广安门医院,北京 100053
  • 3.山东中医药大学附属医院,山东 济南 250011
通讯作者:
* 郭颖(1983-),女,博士,主任医师,从事中医药在辅助生殖领域的相关研究。
作者简介:

亓文隆(2000-),男,硕士研究生,从事中医药在辅助生殖领域的相关研究。

Research Progress on Regulating Metabolic Reprogramming with Traditional Chinese Medicine to Improve Ovarian Aging
Wenlong QI1, Zhicheng JIA2, Yongqian LI1, Peixuan WANG1, Mengyu SHI1, Xinxin YANG1, Xinwei SUN1, Ying GUO1, 3, *
Affiliations
  • 1.Shandong University of Traditional Chinese Medicine, Jinan 250014, China
  • 2.Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
  • 3.The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China
出版时间: 2026-08-20 doi: 10.19664/j.cnki.1002-2392.260171
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卵巢衰老是造成女性不孕的重要因素,其发病机制复杂,目前采用激素替代疗法存在局限性,因此深入探索卵巢衰老的发病机制,寻求安全有效的治疗方法极具临床应用价值。代谢重编程在卵母细胞生长、发育和成熟过程中发挥重要作用,其异常可通过激活相关信号通路和调控凋亡相关蛋白的表达,加速卵巢衰老进程。近年来,中医药调控代谢重编程延缓卵巢衰老的研究取得了一定进展,本文汇总分析了卵巢衰老过程中糖、脂质、氨基酸及免疫代谢等方面的代谢重编程异常,并对中药提取物和中药复方调控这些核心代谢环节的重编程异常,从而延缓卵巢衰老进程的相关研究进行归纳总结,以期从中医药调控代谢重编程角度,为延缓卵巢衰老、提高女性生育能力提供新的临床治疗思路。

中医药  /  代谢重编程  /  卵巢衰老  /  不孕  /  综述

Ovarian aging is an important factor causing female infertility, and its pathogenesis is complex. Currently, the use of hormone replacement therapy has limitations. Therefore, in-depth exploration of the pathogenesis of ovarian aging and seeking safe and effective treatment methods have great clinical application value. Metabolic reprogramming plays an important role in the growth, development, and maturation of oocytes, and its abnormalities can accelerate ovarian aging by activating related signaling pathways and regulating the expression of apoptosis related proteins. In recent years, research on the regulation of metabolic reprogramming by traditional Chinese medicine to delay ovarian aging has made certain progress. This article summarizes and analyzes the metabolic reprogramming abnormalities in sugar, lipid, amino acid, and immune metabolism during ovarian aging, and summarizes the relevant studies on the regulation of these core metabolic links by traditional Chinese medicine extracts and formulas to delay the process of ovarian aging. The aim is to provide new clinical treatment ideas for delaying ovarian aging and improving female fertility from the perspective of regulating metabolic reprogramming by traditional Chinese medicine.

Traditional Chinese Medicine (TCM)  /  Metabolic reprogramming  /  Ovarian aging  /  Infertility  /  Review
亓文隆, 贾志诚, 李永谦, 王培璇, 石梦雨, 杨鑫鑫, 孙昕玮, 郭颖. 中医药调控代谢重编程改善卵巢衰老的研究进展. 中医药学报, 2026 , 54 (8) : 119 -128 . DOI: 10.19664/j.cnki.1002-2392.260171
Wenlong QI, Zhicheng JIA, Yongqian LI, Peixuan WANG, Mengyu SHI, Xinxin YANG, Xinwei SUN, Ying GUO. Research Progress on Regulating Metabolic Reprogramming with Traditional Chinese Medicine to Improve Ovarian Aging[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (8) : 119 -128 . DOI: 10.19664/j.cnki.1002-2392.260171
  • 国家自然科学基金面上项目(82374505)
  • 山东省自然科学基金面上项目(ZR2023MH219)
  • 济南市科技发展计划项目(202225005)
  • 泰山学者青年专家项目(202211353)
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doi: 10.19664/j.cnki.1002-2392.260171
  • 接收时间:2025-03-15
  • 首发时间:2026-09-17
  • 出版时间:2026-08-20
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  • 收稿日期:2025-03-15
  • 修回日期:2025-10-21
基金
国家自然科学基金面上项目(82374505)
山东省自然科学基金面上项目(ZR2023MH219)
济南市科技发展计划项目(202225005)
泰山学者青年专家项目(202211353)
作者信息
    1.山东中医药大学,山东 济南 250014
    2.中国中医科学院广安门医院,北京 100053
    3.山东中医药大学附属医院,山东 济南 250011

通讯作者:

* 郭颖(1983-),女,博士,主任医师,从事中医药在辅助生殖领域的相关研究。
参考文献
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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260171
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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