Article(id=1307264914683351168, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307264617252680149, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260167, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1741104000000, receivedDateStr=2025-03-05, revisedDate=1777305600000, revisedDateStr=2026-04-28, acceptedDate=null, acceptedDateStr=null, onlineDate=1789605843468, onlineDateStr=2026-09-17, pubDate=1787155200000, pubDateStr=2026-08-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789605843468, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789605843468, creator=13701087609, updateTime=1789605843468, updator=13701087609, issue=Issue{id=1307264617252680149, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='8', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1787155200000', pubDateStr='2026-08-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789605772555, creator='13701087609', updateTime=1789605772555, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=92, endPage=97, ext={EN=ArticleExt(id=1307264914830151809, articleId=1307264914683351168, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Clinical Study on the Self-Formulated Jianpi Chuji Formula for Ameliorating Adverse Reactions Following Immune Checkpoint Inhibitor Therapy in Patients with Advanced Non-Small Cell Lung Cancer, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: Investigating the Clinical Efficacy of a self-formulated Jianpi Chuji Formula in Alleviating Toxic Side Effects Following Immune Checkpoint Inhibitor (ICI) Therapy in Advanced Non-Small Cell Lung Cancer Patients.
Methods: A total of 98 patients with advanced non-small cell lung cancer (NSCLC) who received immunotherapy (ICIs) at Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province from May 2019 to May 2021 were enrolled as study subjects. They were randomly divided into a control group (n=49) and a treatment group (n = 49). The control group received immune checkpoint inhibitor therapy combined with a platinum-based dual-drug regimen. The treatment group received the same regimen supplemented with self-formulated Jianpi Chuji Formula. Changes in thyroid function indicators, Traditional Chinese Medicine (TCM) syndrome scores, Karnofsky Performance Status (KPS), carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), adverse reaction incidence, and clinical efficacy were compared between the two groups.
Results: Following treatment, both groups exhibited elevated levels of thyroid-stimulating hormone (TSH) and KPS scores. Symptoms including fatigue, skin keratosis, pain, limb numbness, sallow complexion, pulse, dark tongue, total score, total thyroxine (TT4), free triiodothyronine (FT3), free thyroxine (FT4), CYFRA21-1, and CEA levels decreased in both groups, with greater improvement observed in the treatment group compared to the control group (P < 0. 01). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P >0. 05). Compared to the control group, the treatment group demonstrated higher objective response rates (ORR) and disease control rates (DCR) (P <0. 01). Multivariate analysis showed that age and pathological type had no significant effect on treatment response (P >0. 05) ; After 6 months of follow-up, progression-free survival was better in the treatment group than that in the control group (P <0.05).
Conclusion: Treatment with self-formulated Jianpi Chuji Formula in non-small cell lung cancer patients following ICIs therapy demonstrated significant efficacy. This approach effectively improved patients' quality of life, reduced tumor marker levels, enhanced thyroid function, and decreased the incidence of toxic side effects.
, authors=Ya'nan MENG, Jinhong LI
*, Yue JIANG, authorsList=Ya'nan MENG, Jinhong LI, Yue JIANG, authorCompany=null, correspAuthors=Jinhong LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307264915182473346, articleId=1307264914683351168, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=自拟健脾除积方改善晚期非小细胞肺癌患者免疫检查点抑制剂治疗后毒副反应的临床研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探究自拟健脾除积方改善晚期非小细胞肺癌患者免疫检查点抑制剂（ICIs）治疗后毒副反应的临床效果。
方法： 选取2019年5月—2021年5月于河北省沧州中西医结合医院接受ICIs治疗的98例晚期非小细胞肺癌患者为研究对象，将其随机分为对照组和治疗组，每组49例。对照组选用免疫检查点抑制剂+含铂双药治疗，治疗组则是在对照组基础上联合自拟健脾除积方进行治疗。比较两组甲状腺功能指标、中医证候积分、卡式功能状态评分（KPS）、癌胚抗原（CEA）、细胞角蛋白19片段（CY-FRA21-1）、不良反应发生率、临床疗效的情况变化。
结果： 治疗后，两组促甲状腺激素（TSH）、KPS评分升高（P < 0.05），体倦乏力、肌肤甲错、疼痛、肢体麻木、面色晦暗、脉涩、舌暗、总积分、总甲状腺素（TT4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、CYFRA21-1、CEA水平降低（P < 0.05），且治疗组情况改善优于对照组（P < 0.01）。两组的重度不良反应发生率对比，差异无统计学意义（P >0.05）。与对照组比较，研究组的客观缓解率（ORR）、疾病控制率（DCR）均较高（P < 0.01）。多因素分析显示，年龄、病理类型对疗效无显著影响（P > 0.05）；随访6个月，治疗组无进展生存期优于对照组（P < 0.05）。
结论： ICIs治疗后的非小细胞肺癌患者应用自拟健脾除积方进行治疗，效果显著，可有效提升患者生活质量，降低肿瘤标志物水平，改善甲状腺功能，减少毒副反应的发生率。
, authors=孟雅楠, 李金红
*, 蒋玥, authorsList=孟雅楠, 李金红, 蒋玥, authorCompany=null, correspAuthors=李金红, authorNote=
孟雅楠（1990-），女，硕士，主治医师，从事肿瘤学相关研究。
, correspAuthorsNote=
* 李金红（1979-），女，副主任医师，从事肿瘤内科相关研究。
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孟雅楠（1990-），女，硕士，主治医师，从事肿瘤学相关研究。
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