Article(id=1307264627017019928, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307264617252680149, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260164, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1742486400000, receivedDateStr=2025-03-21, revisedDate=1774281600000, revisedDateStr=2026-03-24, acceptedDate=null, acceptedDateStr=null, onlineDate=1789605774883, onlineDateStr=2026-09-17, pubDate=1787155200000, pubDateStr=2026-08-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789605774883, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789605774883, creator=13701087609, updateTime=1789605774883, updator=13701087609, issue=Issue{id=1307264617252680149, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='8', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1787155200000', pubDateStr='2026-08-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789605772555, creator='13701087609', updateTime=1789605772555, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=76, endPage=80, ext={EN=ArticleExt(id=1307264628589883929, articleId=1307264627017019928, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Influence of Yangxin Decoction Combined with Valsartan on the TLR4/MyD88/NF-κB Pathway in Elderly Patients with Hypertension and Heart Failure, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
To observe the effect of Yangxin Decoction combined with Valsartan on the Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-κB (NF-κB) pathway in peripheral blood mononuclear cells of elderly patients with hypertension complicated with heart failure (referred to as heart failure).
Methods: A total of 82 elderly patients with hypertension complicated by heart failure and deficiency of qi-blood, as well as restlessness of the mind were selected from Henan Provincial Veterans' Hospital from January 2022 to January 2024. They were divided into the control group and the treatment group according to the random number table method, with 41 cases in each group. Both groups were given symptomatic treatment. The control group was treated with valsartan, while the treatment group was treated with Yangxin Decoction combined with valsartan. Both groups were given continuous treatment for 8 weeks. The cardiac function indicators, blood pressure, TLR4/Macrophage Differentiation Factor 88 (MyD88)/Nuclear Factor-κB (NF-κB) pathway factors, C1q Tumor Necrosis Factor-related Protein 3 (CTRP3), N-terminal Brain Natriuretic Peptide precursor (NT-proBNP), Troponin I (cTnI), and high-sensitivity C-reactive protein (hs-CRP) levels were compared between the two groups, and the incidence of adverse reactions was statistically analyzed.
Results There was no significant difference in the pre-treatment cardiac function indicators, blood pressure, CTRP3, BNP, cTnI, and hs-CRP between the two groups (P >0.05). After treatment, the left ventricular ejection fraction (LVEF), CTRP3, and the ratio of early to late diastolic filling velocity (E/A) in both groups increased compared with those before treatment, while blood pressure, BNP, left ventricular end-systolic diameter (LVESD), cTnI, hs-CRP, and left ventricular end-diastolic diameter (LVEDD) decreased (P <0.05). The LVEF and E/A in the treatment group were higher than those in the control group after treatment, while LVESD and LVEDD were lower (P < 0.05). There was no significant difference in the TLR4/MyD88/NF-κB pathway factors before treatment between the two groups (P > 0.05). After treatment, the relative expression levels of TLR4, MyD88, and NF-κB in both groups decreased compared with those before treatment (P < 0. 05). The relative expression levels of TLR4, MyD88, and NF-κB in the treatment group were lower than those in the control group after treatment (P <0.05). There was no significant difference in the cumulative incidence of adverse reactions between the two groups (P > 0.05).
Conclusion: The combination of Yangxin Decoction and Valsartan can regulate the TLR4/MyD88/NF-κB signaling pathway in elderly patients with hypertension, improve cardiac function, lower blood pressure, and does not increase adverse reactions.
, authors=Zhihua GUO
1, Lingzhi REN
1, Jing WANG
2, authorsList=Zhihua GUO, Lingzhi REN, Jing WANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307264628963176986, articleId=1307264627017019928, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=养心汤联合缬沙坦对老年高血压合并心衰患者TLR4/ MyD88/ NF-κB通路的影响, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 观察养心汤联合缬沙坦对老年高血压合并心力衰竭（简称心衰）患者血清Toll样受体4 （TLR4）、髓样分化因子88（MyD88）和核因子-κB（NF-κB）水平的影响。
方法： 选取河南省荣军医院2022年1月—2024年1月收治的老年高血压合并心衰气血不足、心神不宁证患者82例，根据随机数字表法分为对照组和治疗组，每组41例。两组各剔除1例，最终两组各40例完成研究。两组均给予对症治疗，对照组采用缬沙坦治疗，治疗组采用养心汤联合缬沙坦治疗，两组连续用药8周。比较两组心功能指标、血压、血清TLR4、MyD88、NF-κB水平、C1q肿瘤坏死因子相关蛋白3（CTRP3）、氨基末端脑利钠肽前体（NT-proBNP）、肌钙蛋白I（cTnI）、高敏-C反应蛋白（hs-CRP）水平，统计两组不良反应发生率。
结果： 两组治疗前心功能指标、血压、CTRP3、BNP、cTnI、hs-CRP差异无统计学意义（P > 0.05）。两组治疗后左室射血分数（LVEF）、CTRP3、左室舒张早期和晚期充盈速度比值（E/A）较治疗前升高（P < 0.05），血压、BNP、左心室收缩末期内径（LVESD）、cTnI、hs-CRP、左心室舒张末期内径（LVEDD）较治疗前降低（P < 0.05）。治疗组治疗后LVEF、E/A高于对照组（P < 0.05），LVESD、LVEDD低于对照组（P < 0.05）。两组治疗前血清TLR4、MyD88、NF-κB水平差异无统计学意义（P > 0.05）。两组治疗后血清TLR4、MyD88、NF-κB水平较治疗前降低（P < 0.05）。治疗组治疗后血清TLR4、MyD88、NF-κB水平低于对照组（P < 0.05）。两组累计不良反应发生率比较差异无统计学意义（P > 0.05）。
结论： 养心汤联合缬沙坦可调控老年高血压合并心衰患者TLR4/MyD88/NF-κB信号通路，改善心功能，降低血压，且不增加不良反应。
, authors=郭志华
1, 任凌之
1, 王静
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郭志华（1983-），女，主治医师，从事中医治疗高血压病、心力衰竭等相关研究。
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