Article(id=1307264617709859285, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307264617252680149, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260163, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756137600000, receivedDateStr=2025-08-26, revisedDate=1779984000000, revisedDateStr=2026-05-29, acceptedDate=null, acceptedDateStr=null, onlineDate=1789605772663, onlineDateStr=2026-09-17, pubDate=1787155200000, pubDateStr=2026-08-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789605772663, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789605772663, creator=13701087609, updateTime=1789605772663, updator=13701087609, issue=Issue{id=1307264617252680149, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='8', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1787155200000', pubDateStr='2026-08-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789605772555, creator='13701087609', updateTime=1789605772555, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=69, endPage=75, ext={EN=ArticleExt(id=1307264617877631446, articleId=1307264617709859285, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Clinical Study on Qutan Huayu Tongbi Decoction Combined with VRD Regimen in the Treatment of Multiple Myeloma with Phlegm-Stasis Obstructing Collateral Syndrome, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the efficacy of Qutan Huayu Tongbi Decoction combined with VRD regimen in the treatment of multiple myeloma (MM) with phlegm-stasis obstructing collateral syndrome.
Methods: A prospective randomized controlled placebo study was conducted, enrolling 132 MM patients with phlegm-stasis obstructing collateral syndrome admitted to the Department of Hematopathy of Qingyang Traditional Chinese Medicine Hospital from January 2022 to December 2024. Patients were randomly divided into two groups using a random number table. The control group (66 cases) received VRD chemotherapy combined with Chinese medicine placebo, while the observation group (66 cases) received VRD chemotherapy combined with Qutan Huayu Tongbi Decoction. Both groups were treated continuously for 4 cycles. The chemotherapy efficacy, TCM syndrome score, degree of bone pain, quality of life, blood biochemistry, coagulation indicators and adverse reactions were compared between the two groups.
Results: The DCR (95. 45% vs 63. 63%), ORR (81. 82% vs 51. 52%), and the total effective rate of traditional Chinese medicine (93. 94% vs 77. 27%) in the observation group were all higher than those in the control group (P <0.01), while the overall incidence of adverse reactions was lower (7. 58% vs 22. 73% , P <0.05). After treatment, both groups showed a decrease in TCM syndrome score, bone pain Visual Analog Scale (VAS) score, and levels of vascular endothelial growth factor (VEGF), derived neutrophil-to-lymphocyte ratio (dNLR), neutrophil-to-lymphocyte ratio (NLR), bone marrow plasma cell proportion, β2-microglobulin (β2-MG), lactate dehydrogenase (LDH), serum creatinine (Scr), blood urea nitrogen (BUN), D-dimer (D-D), and plasma fibrinogen (FIB) compared to before treatment (P < 0.01), with the observation group showing lower values than the control group (P < 0.01). The lymphocyte-to-monocyte ratio (LMR), hemoglobin (Hb), Karnofsky Performance Status (KPS) score, and Activities of Daily Living (ADL) score increased compared to before treatment (P < 0.05), with the observation group showing higher values than the control group (P <0.01). Prothrombin time (PT) and activated partial thromboplastin time (APTT) were prolonged compared to before treatment (P < 0.01), with the observation group showing longer times than the control group (P < 0.01).
Conclusion: The combination of Qutan Huayu Tongbi Decoction and VRD chemotherapy regimen can effectively enhance the therapeutic effect of chemotherapy for multiple myeloma, alleviate clinical symptoms, bone pain and anemia, improve coagulation and renal functions, regulate immune inflammation, enhance the physical condition and quality of life of patients, and has good safety.
, authors=Rong SUN, Jianmei ZHANG, Jie WANG, Xiaogang CHANG, Shengmei WANG
*, authorsList=Rong SUN, Jianmei ZHANG, Jie WANG, Xiaogang CHANG, Shengmei WANG, authorCompany=null, correspAuthors=Shengmei WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307264619924451799, articleId=1307264617709859285, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=祛痰化瘀通痹汤联合VRD方案治疗多发性骨髓瘤痰瘀痹阻证的临床研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探讨祛痰化瘀通痹汤联合VRD方案治疗多发性骨髓瘤痰瘀痹阻证的疗效。
方法： 采用前瞻性随机对照安慰剂研究设计，选取2022年1月—2024年12月庆阳市中医医院血液肿瘤科收治的132例痰瘀痹阻型多发性骨髓瘤患者，随机数字表法分为对照组和观察组，每组66例。对照组接受VRD方案化疗联合中药安慰剂治疗，观察组接受祛痰化瘀通痹汤联合VRD方案化疗，两组均连续治疗4个周期。比较两组化疗疗效、中医证候积分、骨痛程度、生活质量以及血生化、凝血指标以及不良反应。
结果： 观察组的疾病控制率（95.45% vs 63.63%）、客观缓解率（81.82% vs 51.52%）和中医证候总有效率（93.94% vs 77.27%）均显著高于对照组（P < 0.01），且不良反应总发生率更低（7.58% vs 22.73%，P < 0.05）。两组治疗后中医证候积分、骨痛视觉模拟评分法（VAS）评分、血管内皮生长因子（VEGF）、衍生中性粒细胞淋巴细胞比值（dNLR）、中性粒细胞淋巴细胞比值（NLR）、骨髓浆细胞比例、β2-微球蛋白（Β2-MG）、乳酸脱氢酶（LDH）、血肌酐（Scr）、血尿素氮（BUN）、D-二聚体（D-D）、血浆纤维蛋白原（FIB）水平较治疗前降低（P < 0.01），且观察组低于对照组（P < 0.01）；淋巴细胞单核细胞比值（LMR）、血红蛋白（HG）、Karnofsky功能状态（KPS）评分、常生活活动能力（ADL）评分较治疗前增高（P < 0.01），且观察组高于对照组（P < 0.01）；凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）较治疗前延长（P < 0.01），且观察组长于对照组（P < 0.01）。
结论： 祛痰化瘀通痹汤联合VRD方案化疗能有效提高多发性骨髓瘤化疗疗效，减轻临床症状、骨痛和贫血程度，改善凝血功能和肾功能，调节免疫炎症，提升患者体能状态和生活质量，且安全性较好。
, authors=孙榕, 张建梅, 王杰, 常小刚, 王生梅
*, authorsList=孙榕, 张建梅, 王杰, 常小刚, 王生梅, authorCompany=null, correspAuthors=王生梅, authorNote=
孙榕（1983-），女，硕士，副主任医师，研究方向：多发性骨髓瘤的中医药防治。
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* 王生梅（1985 -），女，副主任医师，研究方向：恶性血液病的临床诊疗。
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孙榕（1983-），女，硕士，副主任医师，研究方向：多发性骨髓瘤的中医药防治。
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孙榕（1983-），女，硕士，副主任医师，研究方向：多发性骨髓瘤的中医药防治。
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