Article(id=1307264624592712193, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307264617252680149, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260162, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1748016000000, receivedDateStr=2025-05-24, revisedDate=1777305600000, revisedDateStr=2026-04-28, acceptedDate=null, acceptedDateStr=null, onlineDate=1789605774305, onlineDateStr=2026-09-17, pubDate=1787155200000, pubDateStr=2026-08-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789605774305, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789605774305, creator=13701087609, updateTime=1789605774305, updator=13701087609, issue=Issue{id=1307264617252680149, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='8', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1787155200000', pubDateStr='2026-08-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789605772555, creator='13701087609', updateTime=1789605772555, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=64, endPage=68, ext={EN=ArticleExt(id=1307264624726929922, articleId=1307264624592712193, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Clinical Efficacy and Safety of a Self-designed Yiqi Yangyin Tongluo Formula Combined with Intestinal Microecological Regulators in the Treatment of Rheumatoid Arthritis, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To observe the clinical efficacy and safety of self-designed Yiqi Yangyin Tongluo Formula combined with intestinal microecological regulators in the treatment of rheumatoid arthritis.
Methods: A prospective cohort study was conducted on 120 patients with rheumatoid arthritis admitted to Xinyang Central Hospital from January 2022 to January 2025, using a random number table method. Both groups received leflunomide tablets. The conventional group was treated with intestinal microecological modulators, while the combined group received self-designed Yiqi Yangyin Tongluo Formula combined with intestinal microecological modulators. Microbiome diversity metrics (evenness and richness), anti-cyclic citrullinated peptide (CCP) antibody levels, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured in both groups. Clinical efficacy outcomes were statistically analyzed.
Results: There was no difference in the uniformity and richness of the microbiome flora between the two groups before treatment (P >0.05). Before and after treatment, the uniformity and richness of the microbiome in both groups increased, and the uniformity and richness of the microbiome in the comprehensive group after treatment were higher than those in the conventional group (P <0.05). There was no difference in the relevant scores between the two groups before treatment (P >0.05). Before and after treatment, the scores of the Arthritis Quality of Life Scale 2 (AIMS2-SF) in both groups increased, and the comprehensive group was higher than the conventional group after treatment (P < 0.05). The TCM symptom scores, DAS28 scores and VAS scores of both groups decreased, and the comprehensive group was lower than the conventional group (P < 0.05). There was no difference in anti-CCP antibody, ESR and CRP between the two groups before treatment (P > 0.05). Before and after treatment, the anti-CCP antibody, ESR and CRP in both groups decreased, and the comprehensive group was lower than the conventional group after treatment (P <0.05). The improvement rate of ACR20 in the comprehensive group was 61. 67%, which was higher than 43. 33% in the conventional group. The improvement rates of ACR50 and ACR70 were 46. 67% and 15. 00% respectively, and there was no difference compared with 31. 67% and 6. 67% in the control group (P >0.05).
Conclusion: The Self-designed Yiqi Yangyin Tongluo Formula combined with intestinal microecological regulators in the treatment of rheumatoid arthritis can reduce the levels of anti-CCP antibody, ESR and CRP, alleviate symptoms.
, authors=Sheng ZHANG, Qiankun ZHANG, authorsList=Sheng ZHANG, Qiankun ZHANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307264625054085635, articleId=1307264624592712193, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=自拟益气养阴通络方联合肠道微生态调节剂治疗类风湿关节炎的临床效果及安全性, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 观察自拟益气养阴通络方联合肠道微生态调节剂治疗类风湿关节炎的临床疗效及安全性。
方法： 前瞻性选取信阳市中心医院2022年1月—2025年1月收治的类风湿关节炎患者120例，采用随机数字表法分为常规组和综合组，每组60例。两组均给予来氟米特片治疗，常规组加用肠道微生态调节剂治疗，综合组加用自拟益气养阴通络方联合肠道微生态调节剂治疗。检测两组微生物组菌群均匀度与丰富度、抗环瓜氨酸肽（CCP）抗体、血沉（ESR）、C反应蛋白（CRP）水平，统计两组临床疗效。
结果： 两组治疗前微生物组菌群均匀度、丰富度比较差异无统计学意义（P > 0.05）。与治疗前比较，治疗后两组微生物组菌群均匀度、丰富度均升高（P < 0.05），且综合组治疗后微生物组菌群均匀度、丰富度高于常规组（P < 0.05）。两组治疗前相关评分比较差异无统计学意义（P > 0.05）。与治疗前比较，治疗后两组关节炎生活质量量表2（AIMS2-SF）评分升高（P < 0.05），且综合组治疗后高于常规组（P <0.05）；治疗后，两组中医症状积分、DAS28评分、VAS评分均降低（P < 0.05），且综合组低于常规组（P <0.05）。两组治疗前抗CCP抗体、ESR、CRP比较差异无统计学意义（P > 0.05）。与治疗前比较，治疗后两组抗CCP抗体、ESR、CRP均降低（P < 0.05），且综合组治疗后低于常规组（P < 0.05）。综合组ACR20改善率为62.71% （37/59）高于常规组43.33% （26/60），ACR50、ACR70改善率分别为47.46% （28/59）、15.25% （9/59）与对照组的31.67% （19/60）、6.67% （4/60）比较差异无统计学意义（P > 0.05）。
结论： 自拟益气养阴通络方联合肠道微生态调节剂治疗类风湿关节炎可降低抗CCP抗体、ESR、CRP水平，减轻症状。
, authors=张晟, 张乾坤, authorsList=张晟, 张乾坤, authorCompany=null, correspAuthors=null, authorNote=
张晟（1984-），男，硕士，副主任中医师，研究方向：风湿免疫病的中西结合治疗。
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张晟（1984-），男，硕士，副主任中医师，研究方向：风湿免疫病的中西结合治疗。
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张晟（1984-），男，硕士，副主任中医师，研究方向：风湿免疫病的中西结合治疗。
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