Article(id=1307264810635256234, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307264617252680149, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260161, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1741276800000, receivedDateStr=2025-03-07, revisedDate=1765123200000, revisedDateStr=2025-12-08, acceptedDate=null, acceptedDateStr=null, onlineDate=1789605818660, onlineDateStr=2026-09-17, pubDate=1787155200000, pubDateStr=2026-08-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789605818660, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789605818660, creator=13701087609, updateTime=1789605818660, updator=13701087609, issue=Issue{id=1307264617252680149, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='8', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1787155200000', pubDateStr='2026-08-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789605772555, creator='13701087609', updateTime=1789605772555, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=58, endPage=63, ext={EN=ArticleExt(id=1307264810807222699, articleId=1307264810635256234, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effects of Sihuang Shengji Decoction on Postoperative Anal Function and Levels of ACTA, IL-1α, and PDGF in Patients with Perianal Abscess, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To analyze the effects of Sihuang Shengji decoction on serum activin A (AC-TA), interleukin-1 α (IL-1α), and platelet-derived growth factor (PDGF) after perianal abscess surgery with damp-heat toxicity accumulation.
Methods: 176 patients with perianal abscess who were treated by surgery in the Fourth People's Hospital of Jinan from December 2022 to December 2024 were selected and randomly divided into routine group and decoction group, with 88 cases in each group. Conventional group: Received conventional postoperative treatment. Decoction group: On the basis of the control group, Sihuang Shengji Decoction was used for treatment. Evaluate the level of TCM syndrome scores of patients; Calculate the improvement time of symptoms in the two groups; The degree of pain of the patients was evaluated by using the VAS score scale. The anal function of the patients was evaluated using the Wexner scoring scale; Detect the maximum systolic pressure of the anal canal and the resting pressure of the anal canal; Detect the levels of VEGF, TGF-β1, SOD, MDA, AC-TA, IL-1α and PDGF. Compare the clinical effective situation.
Results: After treatment, compared with the conventional group, TCM syndrome score, Wexner score, VAS score, MDA, AC-TA, IL-1 α level were decreased (P < 0.01) ; maximum anal tube systolic pressure, anal resting pressure, VE GF, TGF-β1, SOD, and PDGF levels were increased (P < 0.01) ; improvement time of symptoms in the decoction group was shortened (P <0.01) ; total response rate increased in the decoction group (P < 0.01). The incidence of adverse reactions in the decoction group was higher than that in the conventional group (P > 0.05).
Conclusion: For postoperative patients with perianal abscess caused by damp-heat toxicity accumulation, the treatment with Sihuang Shengji decoction can reduce the level of TCM syndrome score, improve anal function, and regulate the levels of serum AC-TA, IL-1α, and PDGF, with remarkable clinical effects.
, authors=Yuanyuan MA
1, Chunhua CHI
2, Jiawei SUN
1, *, authorsList=Yuanyuan MA, Chunhua CHI, Jiawei SUN, authorCompany=null, correspAuthors=Jiawei SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307264811155349932, articleId=1307264810635256234, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=四黄生肌汤对肛周脓肿术后肛门功能及AC-TA、IL-1α、PDGF水平的影响, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 分析四黄生肌汤对湿热毒蕴肛周脓肿术后血清激活素A（AC-TA）、白细胞介素-1α（IL-1α）、血小板源性生长因子（PDGF）的影响。
方法： 选取济南市第四人民医院 2022年12月—2024年12月收治的肛周脓肿手术治疗患者176例，随机分为常规组和汤药组，每组88例。常规组进行常规术后治疗。汤药组在对照组基础上进行四黄生肌汤治疗。评估患者中医证候积分情况；统计两组症状改善时间；采用VAS评分量表评估患者疼痛程度；采用Wexner评分量表评估患者肛门功能；检测肛管最大收缩压、肛管静息压；检测VEGF、TGF-β1、SOD、MDA、AC-TA、IL-1α、PDGF水平。对比两组临床有效情况。
结果： 治疗后，与常规组比较，汤药组中医证候积分、Wexner评分、VAS评分、MDA、AC-TA、IL-1α水平降低（P < 0.01）；肛管最大收缩压、肛管静息压、VEGF、TGF-β1、SOD、PDGF水平升高（P < 0.01）；汤药组症状改善时间缩短（P < 0.01）；汤药组总有效率升高（P < 0.01）。汤药组总不良反应发生率高于常规组，但差异无统计学意义（P > 0.05）。
结论： 对湿热毒蕴肛周脓肿术后患者，采用四黄生肌汤进行治疗，能降低中医证候积分，改善肛门功能，调节血清AC-TA、IL-1α、PDGF水平，临床效果显著。
, authors=马媛媛
1, 迟春华
2, 孙嘉伟
1, *, authorsList=马媛媛, 迟春华, 孙嘉伟, authorCompany=null, correspAuthors=孙嘉伟, authorNote=
马媛媛（1987-），女，硕士，主治医师，主要从事肛肠病学相关临床工作。
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* 孙嘉伟（1982-），男，硕士，副主任医师，主要从事肛肠病学相关临床工作。
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