Article(id=1307269513221791785, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269479684133809, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260152, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758470400000, receivedDateStr=2025-09-22, revisedDate=1774454400000, revisedDateStr=2026-03-26, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606939845, onlineDateStr=2026-09-17, pubDate=1784476800000, pubDateStr=2026-07-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606939845, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606939845, creator=13701087609, updateTime=1789606939845, updator=13701087609, issue=Issue{id=1307269479684133809, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='7', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1784476800000', pubDateStr='2026-07-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606931849, creator='13701087609', updateTime=1789606931849, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=122, endPage=128, ext={EN=ArticleExt(id=1307269513397952554, articleId=1307269513221791785, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Research Progress on the Regulation of TLR4/NF-κB Pathway by Traditional Chinese Medicine in the Intervention of Epilepsy, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Epilepsy is a neurological disorder characterized by complex and diverse pathogenesis, involving abnormal activation of multiple signaling pathways. In recent years, with the in-depth study of the pathogenesis of epilepsy, traditional Chinese medicine (TCM) has shown unique advantages as a traditional treatment method in the treatment of epilepsy. Especially, TCM has exerted significant anti-epileptic effects by regulating the Toll-like receptor 4 (TLR4) nuclear factor NF-κB signaling pathway. This article aims to review the latest research progress of TCM in regulating the TLR4/NF-κB pathway, focusing on analyzing the mechanisms of active components and compound prescriptions of traditional Chinese medicine via the TLR4/NF-κB pathway, in order to provide reference and inspiration for future research.

, authors=Liyang WEN^{1, 2}, Peng Liu², Jian Xue², Guangyu Cheng², Na Qi^{1, *}, authorsList=Liyang WEN, Peng Liu, Jian Xue, Guangyu Cheng, Na Qi, authorCompany=null, correspAuthors=Na Qi, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269513829965867, articleId=1307269513221791785, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=中医药调控TLR4/NF-κB通路干预癫痫的研究进展, columnId=1303760941036888710, journalTitle=中医药学报, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

癫痫是一种神经系统疾病，其机制复杂、病因多样，涉及多种信号通路的异常激活。近年来，随着对癫痫发病机制的深入研究，中医药在癫痫的治疗中展现出独特优势，特别是中医药通过调控Toll样受体4（TLR4）/ NF-κB信号通路，发挥了显著的抗癫痫作用。本文旨在综述中药活性成分、中药复方在调控TLR4/NF-κB通路方面干预癫痫的最新研究进展，并探讨中医药在癫痫治疗中的潜在应用前景，以期为今后的研究提供参考和启示。

, authors=文立杨^{1, 2}, 刘鹏², 薛剑², 程光宇², 齐娜^{1, *}, authorsList=文立杨, 刘鹏, 薛剑, 程光宇, 齐娜, authorCompany=null, correspAuthors=齐娜, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=lGmFUE400vY/HNvzBtR1Hg==, magXml=XyTiwqOzNAp0XFWnpKyIkw==, pdfUrl=null, pdf=MU288LZutYlk3obSBjIoCQ==, pdfFileSize=1192710, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=WOIz7bE5rg/9Gm35TFYDRw==, mapNumber=null, fund=null)}, authors=[Author(id=1307269514190676019, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269513221791785, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1307269514278756406, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1307269513221791785, authorId=1307269514190676019, language=EN, stringName=Liyang WEN, firstName=Liyang, middleName=null, lastName=WEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.Heilongjiang University of Chinese Medicine, Harbin 150040, China
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^2.黑龙江中医药大学附属第一医院，黑龙江 哈尔滨 150040, bio={"content":"

文立杨（1990-），女，博士，主治医师，研究方向：中西医结合治疗神经系统疾病。

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文立杨（1990-），女，博士，主治医师，研究方向：中西医结合治疗神经系统疾病。

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