中医药学报

扶正祛风汤对慢性荨麻疹患者的疗效观察及对活动性评分、血清CRP和免疫球蛋白水平的影响

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白玉蓉 , 高月 ^*

中医药学报 | 临床研究 2026,54(7): 96-102

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中医药学报 |临床研究 2026 , 54 (7) : 96 -102

扶正祛风汤对慢性荨麻疹患者的疗效观察及对活动性评分、血清CRP和免疫球蛋白水平的影响

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白玉蓉, 高月^*

作者信息

北京中医药大学孙思邈医院药学部，陕西铜川 727000

通讯作者:

^* 高月（1987 -），女，主管中药师，从事中药学相关研究。

作者简介:

白玉蓉（1989-），女，主管中药师，从事中药学相关研究。

Efficacy of Fuzheng Qufeng Decoction in Patients with Chronic Urticaria: Observation and Impact on Activity Scores, Serum CRP, and Immunoglobulin Levels

Yurong BAI, Yue GAO^*

Affiliations

Pharmacy Department, SUN Simiao Hospital of BUCM, Tongchuan 727000, China

出版时间: 2026-07-20 doi: 10.19664/j.cnki.1002-2392.260148

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摘要

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目的：

探讨扶正祛风汤对慢性荨麻疹患者的临床疗效、活动性评分（UAS7）、皮肤病生活质量指数（DLQI）及血清C反应蛋白（CRP）、免疫球蛋白水平的影响，并评估其对血清炎症因子、趋化因子及免疫功能的调节作用。

方法：

本研究为前瞻性研究，选取2020年3月—2024年3月在北京中医药大学孙思邈医院进行治疗的211例慢性荨麻疹患者，采用随机数字表法分为对照组106例与观察组105例。对照组接受盐酸左西替利嗪片治疗，观察组在对照组基础上接受扶正祛风汤治疗。两组患者均治疗4周。对两组患者治疗前后UAS7及DLQI进行评估，比较两组患者治疗前后中医证候积分，检测并比较血清炎症因子、趋化因子水平及免疫功能相关指标水平，统计并比较两组患者治疗效果及不良反应发生情况。

结果：

治疗后两组UAS7及DLQI均降低（P < 0.01），治疗后观察组中医证候积分低于对照组（P < 0.01）。治疗后观察组血清IL-17、IL-23、IL-31、IL-33、IFN-γ、TGF-β、CRP、SAA、D-D、MCP-1、RANTES、Eotaxin、C5a、IgE水平均低于对照组（P < 0.01）。治疗后观察组血清C3、C4水平均高于对照组（P < 0.01）。观察组治疗总有效率高于对照组（P < 0.01）。观察组不良反应总发生率低于对照组（P <0.05）。

结论：

扶正祛风汤能够显著改善慢性荨麻疹患者的临床症状、减少UAS7和DLQI评分，降低血清炎症因子及趋化因子水平，提升免疫功能，且安全性较高，不良反应少，具有较好的临床应用价值。

关键词

扶正祛风汤 / 慢性荨麻疹 / 盐酸左西替利嗪片 / 免疫球蛋白 / 炎症因子 / 趋化因子 / 免疫功能

Abstract

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Objective:

To explore the efficacy of Fuzheng Qufeng Decoction in patients with chronic urticaria, its effects on the Weekly Urticaria Activity Score (UAS7), Dermatology Life Quality Index (DLQI), and serum C-reactive protein (CRP) and immunoglobulin levels. Additionally, it evaluated the decoction's regulatory effects on serum inflammatory factors, chemokines, and immune function.

Methods:

This prospective study enrolled 211 patients with chronic urticaria treated at our hospital from March 2020 to March 2024. Patients were randomly assigned into a control group (n=106), receiving levocetirizine hydrochloride tablets, and an observation group (n=105), receiving Fuzheng Qufeng Decoction in combination with levocetirizine hydrochloride. Both groups were treated for 4 weeks. UAS7 and DLQI scores were evaluated before and after treatment in both groups. Traditional Chinese Medicine (TCM) symptom scores, serum levels of inflammatory cytokines, chemokines, and immune function-related indicators were measured and compared between the two groups. The efficacy and incidence of adverse reactions were statistically analyzed.

Results:

After treatment, both the UAS7 and DLQI scores decreased in the observation group and the control group, with median UAS7 and DLQI scores in the observation group being 7.00 and 2.00, respectively, both lower than the control group's 7.50 and 3.00 (P < 0.05). The primary and secondary symptom scores of Traditional Chinese Medicine (TCM) syndromes also decreased in both groups, with the observation group showing significantly lower scores than the control group (P <0.05). Post-treatment, serum levels of IL-17, IL-23, IL-31, IL-33, IFN-γ, TGF-β, CRP, SAA, D-dimer, MCP-1, RANTES, Eotaxin, C5a, and IgE were all lower in the observation group compared to the control group (P <0.05), while serum C3 and C4 levels were higher in the observation group (P <0.05). The total treatment efficacy rate in the observation group was higher than that in the control group. The total incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05).

Conclusion:

Fuzheng Qufeng Decoction significantly improved clinical symptoms, reduced UAS7 and DLQI scores, lowered serum levels of inflammatory cytokines and chemokines, enhanced immune function, and demonstrated high safety with fewer adverse reactions. It holds substantial clinical value for treating chronic urticaria.

Key words

Fuzheng Qufeng Decoction / Chronic urticaria / Levocetirizine hydrochloride / Immunoglobulins / Inflammatory cytokines / Chemokines / Immune function

引用本文

白玉蓉, 高月. 扶正祛风汤对慢性荨麻疹患者的疗效观察及对活动性评分、血清CRP和免疫球蛋白水平的影响. 中医药学报, 2026 , 54 (7) : 96 -102 . DOI: 10.19664/j.cnki.1002-2392.260148

Yurong BAI, Yue GAO. Efficacy of Fuzheng Qufeng Decoction in Patients with Chronic Urticaria: Observation and Impact on Activity Scores, Serum CRP, and Immunoglobulin Levels[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (7) : 96 -102 . DOI: 10.19664/j.cnki.1002-2392.260148

基金

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陕西省重点研发计划项目(2021ZDLSF04-06)

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排序方式：

2026年第54卷第7期

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文章信息

doi: 10.19664/j.cnki.1002-2392.260148

接收时间：2025-01-14
首发时间：2026-09-17
出版时间：2026-07-20

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出版历史

收稿日期：2025-01-14
修回日期：2025-12-02

基金

陕西省重点研发计划项目(2021ZDLSF04-06)

作者信息

北京中医药大学孙思邈医院药学部，陕西铜川 727000

通讯作者:

^* 高月（1987 -），女，主管中药师，从事中药学相关研究。

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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260148

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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