Article(id=1307269559275250048, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269516371719010, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260131, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729267200000, receivedDateStr=2024-10-19, revisedDate=1756915200000, revisedDateStr=2025-09-04, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606950824, onlineDateStr=2026-09-17, pubDate=1781884800000, pubDateStr=2026-06-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606950824, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606950824, creator=13701087609, updateTime=1789606950824, updator=13701087609, issue=Issue{id=1307269516371719010, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='6', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1781884800000', pubDateStr='2026-06-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606940596, creator='13701087609', updateTime=1789606940596, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=118, endPage=126, ext={EN=ArticleExt(id=1307269559434633601, articleId=1307269559275250048, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Research Progress on Chemical Composition and Pharmacological Effects of Cervi Cornu Pantotrichum as a "Cold-region Long Medicine", columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Cervi Cornu Pantotrichum is a traditional precious animal-derived medicinal material in China, with a history of application spanning over two thousand years. Cervi Cornu Pantotrichum from Heilongjiang Province has high yield and superior quality, making it one of the "Long Nine Botanicals" of Cold-region Long Medicine. Cervi Cornu Pantotrichum is rich in various active components such as peptides, fatty acids, and polysaccharides, and possesses multiple pharmacological activities including improving reproductive function, enhancing immunity, promoting wound healing, antioxidant, anti-fatigue, and anti-tumor effects. It can be used to treat various diseases such as chronic heart failure, osteoporosis, Alzheimer's disease, pulmonary fibrosis, and liver fibrosis. Cervi Cornu Pantotrichum stem cells and their exosomes also show great therapeutic potential and application prospects in promoting wound healing and anti-tumor effects. This article reviews the research progress in the chemical composition and pharmacological effects of Cervi Cornu Pantotrichum, aiming to provide a scientific basis for in-depth research and product development of Cervi Cornu Pantotrichum.

, authors=Nuonan LIU, Yuxin QIAO, Zeyu GAO, Li YAO*, authorsList=Nuonan LIU, Yuxin QIAO, Zeyu GAO, Li YAO, authorCompany=null, correspAuthors=Li YAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269559782760834, articleId=1307269559275250048, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=“寒地龙药”鹿茸的化学成分与药理作用研究进展, columnId=1303760941036888710, journalTitle=中医药学报, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

鹿茸是我国传统名贵动物药材,已有两千多年的应用历史。黑龙江省的鹿茸产量高、品质上乘,为寒地龙药“龙九味”之一。鹿茸中富含多肽、脂肪酸、多糖等多种活性成分,具有改善生殖功能、增强免疫、促进创伤愈合、抗氧化、抗疲劳、抗肿瘤等多种药理活性,可治疗慢性心力衰竭、骨质疏松症、阿尔茨海默症、肺纤维化、肝纤维化等多种疾病。鹿茸干细胞及其外泌体在促进创口愈合和抗肿瘤等方面也展现出极大的治疗潜力和应用前景。本文梳理了鹿茸的化学成分、药理作用两个方面的研究进展,以期为鹿茸的深入研究和产品开发提供科学依据。

, authors=柳诺男, 乔雨欣, 高泽宇, 姚丽*, authorsList=柳诺男, 乔雨欣, 高泽宇, 姚丽, authorCompany=null, correspAuthors=姚丽, authorNote=

柳诺男(2003-),女,研究方向:中药及复方药效物质基础与作用机制研究。

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* 姚丽(1979 -),女,博士,教授,研究方向:中药及复方药效物质基础与作用机制研究。
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柳诺男(2003-),女,研究方向:中药及复方药效物质基础与作用机制研究。

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柳诺男(2003-),女,研究方向:中药及复方药效物质基础与作用机制研究。

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“寒地龙药”鹿茸的化学成分与药理作用研究进展
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柳诺男 , 乔雨欣 , 高泽宇 , 姚丽 *
中医药学报 | 研究进展 2026,54(6): 118-126
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中医药学报 |研究进展 2026 , 54 (6) : 118 -126
“寒地龙药”鹿茸的化学成分与药理作用研究进展
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柳诺男, 乔雨欣, 高泽宇, 姚丽*
作者信息
  • 哈尔滨医科大学药学院,黑龙江 哈尔滨 150081
通讯作者:
* 姚丽(1979 -),女,博士,教授,研究方向:中药及复方药效物质基础与作用机制研究。
作者简介:

柳诺男(2003-),女,研究方向:中药及复方药效物质基础与作用机制研究。

Research Progress on Chemical Composition and Pharmacological Effects of Cervi Cornu Pantotrichum as a "Cold-region Long Medicine"
Nuonan LIU, Yuxin QIAO, Zeyu GAO, Li YAO*
Affiliations
  • College of Pharmacy, Harbin Medical University, Harbin 150081, China
出版时间: 2026-06-20 doi: 10.19664/j.cnki.1002-2392.260131
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鹿茸是我国传统名贵动物药材,已有两千多年的应用历史。黑龙江省的鹿茸产量高、品质上乘,为寒地龙药“龙九味”之一。鹿茸中富含多肽、脂肪酸、多糖等多种活性成分,具有改善生殖功能、增强免疫、促进创伤愈合、抗氧化、抗疲劳、抗肿瘤等多种药理活性,可治疗慢性心力衰竭、骨质疏松症、阿尔茨海默症、肺纤维化、肝纤维化等多种疾病。鹿茸干细胞及其外泌体在促进创口愈合和抗肿瘤等方面也展现出极大的治疗潜力和应用前景。本文梳理了鹿茸的化学成分、药理作用两个方面的研究进展,以期为鹿茸的深入研究和产品开发提供科学依据。

鹿茸  /  寒地龙药  /  化学成分  /  药理作用

Cervi Cornu Pantotrichum is a traditional precious animal-derived medicinal material in China, with a history of application spanning over two thousand years. Cervi Cornu Pantotrichum from Heilongjiang Province has high yield and superior quality, making it one of the "Long Nine Botanicals" of Cold-region Long Medicine. Cervi Cornu Pantotrichum is rich in various active components such as peptides, fatty acids, and polysaccharides, and possesses multiple pharmacological activities including improving reproductive function, enhancing immunity, promoting wound healing, antioxidant, anti-fatigue, and anti-tumor effects. It can be used to treat various diseases such as chronic heart failure, osteoporosis, Alzheimer's disease, pulmonary fibrosis, and liver fibrosis. Cervi Cornu Pantotrichum stem cells and their exosomes also show great therapeutic potential and application prospects in promoting wound healing and anti-tumor effects. This article reviews the research progress in the chemical composition and pharmacological effects of Cervi Cornu Pantotrichum, aiming to provide a scientific basis for in-depth research and product development of Cervi Cornu Pantotrichum.

Cervi Cornu Pantotrichum  /  Cold-region Long Medicine  /  Chemical composition  /  Pharmacological effects
柳诺男, 乔雨欣, 高泽宇, 姚丽. “寒地龙药”鹿茸的化学成分与药理作用研究进展. 中医药学报, 2026 , 54 (6) : 118 -126 . DOI: 10.19664/j.cnki.1002-2392.260131
Nuonan LIU, Yuxin QIAO, Zeyu GAO, Li YAO. Research Progress on Chemical Composition and Pharmacological Effects of Cervi Cornu Pantotrichum as a "Cold-region Long Medicine"[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (6) : 118 -126 . DOI: 10.19664/j.cnki.1002-2392.260131
  • 黑龙江省自然科学基金项目(LH2021H016)
  • 中央高校基本科研业务费专项基金(22X010201564)
  • 上海交通大学系统生物医学教育部重点实验室开放研究课题基金(KLSB2022KF-02)
  • 哈尔滨医科大学优势特色学科固强增效计划(HMUMIF-21026)
  • 组分中药重点实验室开放课题(CBCM2024105)
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2026年第54卷第6期
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doi: 10.19664/j.cnki.1002-2392.260131
  • 接收时间:2024-10-19
  • 首发时间:2026-09-17
  • 出版时间:2026-06-20
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  • 收稿日期:2024-10-19
  • 修回日期:2025-09-04
基金
黑龙江省自然科学基金项目(LH2021H016)
中央高校基本科研业务费专项基金(22X010201564)
上海交通大学系统生物医学教育部重点实验室开放研究课题基金(KLSB2022KF-02)
哈尔滨医科大学优势特色学科固强增效计划(HMUMIF-21026)
组分中药重点实验室开放课题(CBCM2024105)
作者信息
    哈尔滨医科大学药学院,黑龙江 哈尔滨 150081

通讯作者:

* 姚丽(1979 -),女,博士,教授,研究方向:中药及复方药效物质基础与作用机制研究。
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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260131
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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