Article(id=1307269554678296703, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269516371719010, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260123, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1736956800000, receivedDateStr=2025-01-16, revisedDate=1765814400000, revisedDateStr=2025-12-16, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606949728, onlineDateStr=2026-09-17, pubDate=1781884800000, pubDateStr=2026-06-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606949728, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606949728, creator=13701087609, updateTime=1789606949728, updator=13701087609, issue=Issue{id=1307269516371719010, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='6', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1781884800000', pubDateStr='2026-06-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606940596, creator='13701087609', updateTime=1789606940596, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=75, endPage=79, ext={EN=ArticleExt(id=1307269554862846080, articleId=1307269554678296703, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effect Analysis on Treating Ischemic Apoplexy (Wind-Phlegm-Stasis Blocking Syndrome) with Modified Tianma Gegen Decoction, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To analyze the effect of Tianma Gegen decoction on ischemic stroke (Wind-Phlegm-Stasis Blocking Syndrome).
Methods: The clinical data of 105 patients with ischemic stroke (Wind-Phlegm-Stasis blocking syndrome) admitted to Rugao Hospital of Traditional Chinese Medicine during January 2021 to December 2023 were retrospectively analyzed. According to different treatment methods, they were divided into control group (n = 55, conventional treatment) and observation group (n = 50, conventional treatment + modified Tianma Gegen decoction). After 2 weeks of continuous treatment, the clinical efficacy, adverse reactions, and TCM symptom scores, degree of neurological impairment [National Institutes of Health Stroke Scale (NIHSS) score], serum indexes [neuron-specific enolase (NSE), matrix metalloproteinase (MMP)-9, intercellular adhesion molecule (ICAM)-1, monocyte chemoattractant protein(MCP)-1] levels before and after treatment were evaluated.
Results: The total effective rate of observation group was 98.00%(49/50), which was higher than that of control group 85.45%(47/55) (P < 0.05). Compared with before treatment, TCM syndrome score, NIHSS score and serum levels of NSE, MMP-9, ICAM-1 and MCP-1 in both groups were decreased after treatment(P < 0.01), and the observation group was lower than the control group(P < 0.01). The total incidence of adverse reactions in observation group and control group was 8.00%(4/50) and 5.45%(3/55), respectively, with no statistical significance(P > 0.05).
Conclusion: The modified Tianma Gegen decoction in the treatment of ischemic stroke (Wind-Phlegm-Stasis Blocking Syndrome) can improve the therapeutic effect, alleviate symptoms, reduce the levels of serum NSE, MMP-9, ICAM-1 and MCP-1, which is conducive to the improvement of neurological impairment, and will not increase the occurrence of adverse reactions.
, authors=Miao ZHANG, Yi YU
*, authorsList=Miao ZHANG, Yi YU, authorCompany=null, correspAuthors=Yi YU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269555290665089, articleId=1307269554678296703, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=天麻葛根汤加减治疗缺血性中风(风痰瘀阻证)的效果分析, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 分析天麻葛根汤加减治疗缺血性中风（风痰瘀阻证）的效果。
方法： 回顾性分析2021年1月—2023年12月如皋市中医院收治的105例缺血性中风（风痰瘀阻证）患者的临床资料，按照治疗方法的不同分为对照组（55例，常规治疗）和观察组（50例，常规治疗+天麻葛根汤加减）。连续治疗2周后评估患者的临床疗效、不良反应及治疗前、后的中医证候积分、神经功能缺损程度［美国国立卫生研究院卒中量表（NIHSS）评分］、血清指标［神经元特异性烯醇化酶（NSE）、基质金属蛋白酶（MMP）-9、细胞间黏附分子（ICAM）-1、单核细胞趋化蛋白（MCP）-1］水平。
结果： 观察组总有效率为98.00% （49/50），高于对照组的85.45%（47/55），差异有统计学意义（P < 0.05）。与治疗前比较，治疗后两组中医证候积分、NIHSS评分及血清NSE、MMP-9、ICAM-1、MCP-1水平均降低（P < 0.01），且观察组低于对照组（P < 0.01）。观察组与对照组的不良反应总发生率分别为8.00%（4/50）、5.45%（3/55），差异无统计学意义（P > 0.05）。
结论： 天麻葛根汤加减辅助治疗缺血性中风（风痰瘀阻证），可提高治疗效果，减轻症状，降低血清NSE、MMP-9、ICAM-1、MCP-1水平，利于神经功能缺损的改善，且不会增加不良反应的发生。
, authors=张淼, 于毅
*, authorsList=张淼, 于毅, authorCompany=null, correspAuthors=于毅, authorNote=
张淼（1990-），女，主治中医师，从事中西医结合治疗神经系统疾病。
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* 于毅（1990-），男，硕士，主治中医师，从事中医内科学相关研究。
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张淼（1990-），女，主治中医师，从事中西医结合治疗神经系统疾病。
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张淼（1990-），女，主治中医师，从事中西医结合治疗神经系统疾病。
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