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Article(id=1307269526781976709, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269516371719010, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260114, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1742400000000, receivedDateStr=2025-03-20, revisedDate=1750694400000, revisedDateStr=2025-06-24, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606943077, onlineDateStr=2026-09-17, pubDate=1781884800000, pubDateStr=2026-06-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606943077, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606943077, creator=13701087609, updateTime=1789606943077, updator=13701087609, issue=Issue{id=1307269516371719010, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='6', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1781884800000', pubDateStr='2026-06-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606940596, creator='13701087609', updateTime=1789606940596, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=25, endPage=34, ext={EN=ArticleExt(id=1307269526987497606, articleId=1307269526781976709, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Study on HPLC Fingerprints and Quantitation Analysis of Four Components in Different Botanical Origins of Lycii Cortex, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To analyze the differences in chemical components between two types of Lycii cortex derived from Lycium chinense Mill. and Lycium barbarum L.

Methods:

HPLC was used to establish the fingerprint profiles of the two kinds of Lycii cortex samples, and the common pattern diagrams were compared for similarity analysis. An HPLC method was developed for the determination of four components: (E)-N-caffeoylputrescine, scopoline, kukoamine B, kukoamine A. Combined with principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA), the differences in chemical components of Lycii cortex from different origins were compared.

Results:

HPLC fingerprints of Lycii cortex from different origins were established. Lycii cortex originated from Lycium chinense Mill. had 14 common peaks, while Lycii cortex originated from Lycium barbarum L. had 11 common peaks. Five common peaks were identified: (E)-N-caffeoylputrescine (Peak 1), scopolin (Peak 2), kukoamine B (Peak 3), kukoamine A (Peak 5), and scopoletin (Peak 6). The quantitative analysis showed good linearity for the four components within the concentration ranges of 1.37 ~ 87.80 μg·mL-1(r=0.999 9), 1.97 ~ 125.83 μg·mL-1(r=0.999 7), 6.31 ~ 403.76 μg·mL-1(r = 0.999 9), and 10.67 ~ 341.57 μg·mL-1 (r = 0.999 8), with average recoveries of 100.52% ~ 103.84% and RSD of 2.33% ~ 3.42%. The content determination results showed that the average percentages of the four components in Lycii cortex originated from Lycium barbarum L. were higher than in Lycium chinense Mill. Chemical pattern recognition analysis classified the two types of Lycii cortex into two categories, and (E)-N-caffeoylputrescine played a prominent role in model construction.

Conclusion:

The established method is accurate and reliable, which can be utilized to distinguish the two varieties of Lycii Cortex and provide a reference for the quality control of them.

, authors=Feng GAO1, 2, Fang TIAN1, Changhong CAO1, Wenting ZHONG1, Yongan CHEN3, Huanjian LIANG3, Menghua WU1, 4, Ying ZHANG1, 2, Hui CAO1, 2, 4, Zhiguo MA1, 2, *, authorsList=Feng GAO, Fang TIAN, Changhong CAO, Wenting ZHONG, Yongan CHEN, Huanjian LIANG, Menghua WU, Ying ZHANG, Hui CAO, Zhiguo MA, authorCompany=null, correspAuthors=Zhiguo MA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269527364984967, articleId=1307269526781976709, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=不同基原地骨皮HPLC指纹图谱与4种成分的含量测定研究, columnId=1303760928135213534, journalTitle=中医药学报, columnName=中药研究, runingTitle=null, highlight=null, articleAbstract=
目的：

研究来源于枸杞Lycium chinense Mill.和宁夏枸杞Lycium barbarum L.的两种地骨皮的化学成分差异。

方法：

采用HPLC法建立两种地骨皮的指纹图谱，进行相似度分析并生成共有模式图；建立咖啡酰丁二胺、东莨菪苷、地骨皮乙素、地骨皮甲素4个成分的含量测定方法，并结合化学模式识别分析，比较两种基原地骨皮的化学成分差异。

结果：

建立了不同基原地骨皮HPLC指纹图谱，枸杞地骨皮有14个共有峰，宁夏枸杞地骨皮有11个共有峰，并指认其中5个共有峰，分别为咖啡酰丁二胺（1号峰）、东莨菪苷（2号峰）、地骨皮乙素（3号峰）、地骨皮甲素（5号峰）、东莨菪内酯（6号峰）；建立的含量测定方法中4种成分的质量浓度分别在1.37 ~ 87.80 μg·mL-1（r=0.999 9）、1.97 ~ 125.83 μg·mL-1 （r = 0.999 7）、6.31 ~ 403.76 μg·mL-1（r=0.999 9）、10.67 ~ 341.57 μg·mL-1（r=0.999 8）范围内线性关系良好，平均回收率为100.52% ~ 103.84%，RSD为2.33% ~ 3.42%；含量测定结果显示宁夏枸杞地骨皮中4个成分平均百分含量均高于枸杞地骨皮；化学模式识别分析可将两种基原地骨皮聚为两类，并且咖啡酰丁二胺在模型构建中具有突出贡献。

结论：

所建立的方法准确、可靠，可用于区分两种基原的地骨皮，也为地骨皮药材的质量控制提供参考。

, authors=高枫1, 2, 田芳1, 曹长鸿1, 钟文婷1, 陈永安3, 梁焕健3, 吴孟华1, 4, 张英1, 2, 曹晖1, 2, 4, 马志国1, 2, *, authorsList=高枫, 田芳, 曹长鸿, 钟文婷, 陈永安, 梁焕健, 吴孟华, 张英, 曹晖, 马志国, authorCompany=null, correspAuthors=马志国, authorNote=

高枫（2000-），男，硕士研究生，主要从事中药质量分析研究。

, correspAuthorsNote=
* 马志国（1979-），男，博士，教授，博士生导师，主要从事中药炮制与中药智能化研究。
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高枫（2000-），男，硕士研究生，主要从事中药质量分析研究。

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高枫（2000-），男，硕士研究生，主要从事中药质量分析研究。

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不同基原地骨皮HPLC指纹图谱与4种成分的含量测定研究
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高枫 1, 2 , 田芳 1 , 曹长鸿 1 , 钟文婷 1 , 陈永安 3 , 梁焕健 3 , 吴孟华 1, 4 , 张英 1, 2 , 曹晖 1, 2, 4 , 马志国 1, 2, *
中医药学报 | 中药研究 2026,54(6): 25-34
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中医药学报 |中药研究 2026 , 54 (6) : 25 -34
不同基原地骨皮HPLC指纹图谱与4种成分的含量测定研究
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高枫1, 2, 田芳1, 曹长鸿1, 钟文婷1, 陈永安3, 梁焕健3, 吴孟华1, 4, 张英1, 2, 曹晖1, 2, 4, 马志国1, 2, *
作者信息
  • 1.暨南大学岭南传统中药研究中心，广东 广州 510632
  • 2.广东省中医药信息化重点实验室，广东 广州 510632
  • 3.广东经典名方科技有限公司，广东 广州 511458
  • 4.国家中药现代化工程技术研究中心岭南资源分中心，广东 广州 510632
通讯作者:
* 马志国（1979-），男，博士，教授，博士生导师，主要从事中药炮制与中药智能化研究。
作者简介:

高枫（2000-），男，硕士研究生，主要从事中药质量分析研究。

Study on HPLC Fingerprints and Quantitation Analysis of Four Components in Different Botanical Origins of Lycii Cortex
Feng GAO1, 2, Fang TIAN1, Changhong CAO1, Wenting ZHONG1, Yongan CHEN3, Huanjian LIANG3, Menghua WU1, 4, Ying ZHANG1, 2, Hui CAO1, 2, 4, Zhiguo MA1, 2, *
Affiliations
  • 1.Research Center for Traditional Chinese Medicine of Lingnan (Southern China), Jinan University, Guangzhou 510632, China
  • 2.Guangdong Key Lab of Traditional Chinese Medicine Information Technology, Guangzhou 510632, China
  • 3.Guangdong Classic Mingfang Technology Co., Ltd., Guangzhou 511458, China
  • 4.National Engineering Research Center for Modernization of Traditional Chinese Medicine Lingnan Resources Branch, Guangzhou 510632, China
出版时间: 2026-06-20 doi: 10.19664/j.cnki.1002-2392.260114
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摘要
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目的：

研究来源于枸杞Lycium chinense Mill.和宁夏枸杞Lycium barbarum L.的两种地骨皮的化学成分差异。

方法：

采用HPLC法建立两种地骨皮的指纹图谱，进行相似度分析并生成共有模式图；建立咖啡酰丁二胺、东莨菪苷、地骨皮乙素、地骨皮甲素4个成分的含量测定方法，并结合化学模式识别分析，比较两种基原地骨皮的化学成分差异。

结果：

建立了不同基原地骨皮HPLC指纹图谱，枸杞地骨皮有14个共有峰，宁夏枸杞地骨皮有11个共有峰，并指认其中5个共有峰，分别为咖啡酰丁二胺（1号峰）、东莨菪苷（2号峰）、地骨皮乙素（3号峰）、地骨皮甲素（5号峰）、东莨菪内酯（6号峰）；建立的含量测定方法中4种成分的质量浓度分别在1.37 ~ 87.80 μg·mL-1（r=0.999 9）、1.97 ~ 125.83 μg·mL-1 （r = 0.999 7）、6.31 ~ 403.76 μg·mL-1（r=0.999 9）、10.67 ~ 341.57 μg·mL-1（r=0.999 8）范围内线性关系良好，平均回收率为100.52% ~ 103.84%，RSD为2.33% ~ 3.42%；含量测定结果显示宁夏枸杞地骨皮中4个成分平均百分含量均高于枸杞地骨皮；化学模式识别分析可将两种基原地骨皮聚为两类，并且咖啡酰丁二胺在模型构建中具有突出贡献。

结论：

所建立的方法准确、可靠，可用于区分两种基原的地骨皮，也为地骨皮药材的质量控制提供参考。

地骨皮  /  不同基原  /  指纹图谱  /  含量测定  /  化学模式识别
Objective:

To analyze the differences in chemical components between two types of Lycii cortex derived from Lycium chinense Mill. and Lycium barbarum L.

Methods:

HPLC was used to establish the fingerprint profiles of the two kinds of Lycii cortex samples, and the common pattern diagrams were compared for similarity analysis. An HPLC method was developed for the determination of four components: (E)-N-caffeoylputrescine, scopoline, kukoamine B, kukoamine A. Combined with principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA), the differences in chemical components of Lycii cortex from different origins were compared.

Results:

HPLC fingerprints of Lycii cortex from different origins were established. Lycii cortex originated from Lycium chinense Mill. had 14 common peaks, while Lycii cortex originated from Lycium barbarum L. had 11 common peaks. Five common peaks were identified: (E)-N-caffeoylputrescine (Peak 1), scopolin (Peak 2), kukoamine B (Peak 3), kukoamine A (Peak 5), and scopoletin (Peak 6). The quantitative analysis showed good linearity for the four components within the concentration ranges of 1.37 ~ 87.80 μg·mL-1(r=0.999 9), 1.97 ~ 125.83 μg·mL-1(r=0.999 7), 6.31 ~ 403.76 μg·mL-1(r = 0.999 9), and 10.67 ~ 341.57 μg·mL-1 (r = 0.999 8), with average recoveries of 100.52% ~ 103.84% and RSD of 2.33% ~ 3.42%. The content determination results showed that the average percentages of the four components in Lycii cortex originated from Lycium barbarum L. were higher than in Lycium chinense Mill. Chemical pattern recognition analysis classified the two types of Lycii cortex into two categories, and (E)-N-caffeoylputrescine played a prominent role in model construction.

Conclusion:

The established method is accurate and reliable, which can be utilized to distinguish the two varieties of Lycii Cortex and provide a reference for the quality control of them.

Lycii cortex  /  Different botanical origin  /  Fingerprints  /  Content determination  /  Chemical pattern recognition
高枫, 田芳, 曹长鸿, 钟文婷, 陈永安, 梁焕健, 吴孟华, 张英, 曹晖, 马志国. 不同基原地骨皮HPLC指纹图谱与4种成分的含量测定研究. 中医药学报, 2026 , 54 (6) : 25 -34 . DOI: 10.19664/j.cnki.1002-2392.260114
Feng GAO, Fang TIAN, Changhong CAO, Wenting ZHONG, Yongan CHEN, Huanjian LIANG, Menghua WU, Ying ZHANG, Hui CAO, Zhiguo MA. Study on HPLC Fingerprints and Quantitation Analysis of Four Components in Different Botanical Origins of Lycii Cortex[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (6) : 25 -34 . DOI: 10.19664/j.cnki.1002-2392.260114
基金
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  • 广州市重点领域科技项目(2021ZD006)
  • 全国名老中医药专家传承工作室项目(国中医药人教函〔2022〕75号)
  • 广东省中医药信息化重点实验室项目(2021B1212040007)
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doi: 10.19664/j.cnki.1002-2392.260114
  • 接收时间：2025-03-20
  • 首发时间：2026-09-17
  • 出版时间：2026-06-20
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  • 收稿日期：2025-03-20
  • 修回日期：2025-06-24
基金
广州市重点领域科技项目(2021ZD006)
全国名老中医药专家传承工作室项目(国中医药人教函〔2022〕75号)
广东省中医药信息化重点实验室项目(2021B1212040007)
作者信息
    1.暨南大学岭南传统中药研究中心，广东 广州 510632
    2.广东省中医药信息化重点实验室，广东 广州 510632
    3.广东经典名方科技有限公司，广东 广州 511458
    4.国家中药现代化工程技术研究中心岭南资源分中心，广东 广州 510632

通讯作者:

* 马志国（1979-），男，博士，教授，博士生导师，主要从事中药炮制与中药智能化研究。
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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260114
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2种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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