Article(id=1307269521379713113, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269516371719010, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260110, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1745251200000, receivedDateStr=2025-04-22, revisedDate=1765382400000, revisedDateStr=2025-12-11, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606941790, onlineDateStr=2026-09-17, pubDate=1781884800000, pubDateStr=2026-06-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606941790, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606941790, creator=13701087609, updateTime=1789606941790, updator=13701087609, issue=Issue{id=1307269516371719010, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='6', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1781884800000', pubDateStr='2026-06-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606940596, creator='13701087609', updateTime=1789606940596, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1, endPage=5, ext={EN=ArticleExt(id=1307269521555873882, articleId=1307269521379713113, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Exploration on the Regulation of Lung Cancer through Short-Chain Fatty Acids Based on the Theory of "Lung and Large Intestine Being Internally-Exteriorly Related", columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=

The incidence and mortality rates of lung cancer remain the highest among all cancers. Although advances have been made in Western medical treatments, limitations still exist due to adverse reactions and drug resistance. The Traditional Chinese Medicine (TCM) theory of "the lung and large intestine being interiorly-exteriorly related" is associated with the modern medical concept of the "lung-gut axis. "It is well-established that both gut microbiota and short-chain fatty acids (SCFAs) are closely linked to the occurrence and progression of lung cancer. This study aims to explore the feasibility and effectiveness of intervening in lung cancer based on the "lung and large intestine being interiorly-exteriorly related" theory from the perspective of SCFAs. The importance of SCFAs in lung cancer treatment and prognosis will be analyzed. A new strategy for intervening in lung cancer by regulating intestinal SCFA levels will be proposed, providing new ideas and methods for comprehensive treatment and prognostic improvement of lung cancer.

, authors=Lingli JIANG, Qiyuan MAO, Ying YANG, Genming ZHANG, Daorui LI*, Hongsheng LIN, authorsList=Lingli JIANG, Qiyuan MAO, Ying YANG, Genming ZHANG, Daorui LI, Hongsheng LIN, authorCompany=null, correspAuthors=Daorui LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269521883029595, articleId=1307269521379713113, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于“肺与大肠相表里”理论探讨从短链脂肪酸角度调控肺癌, columnId=1303760927581561416, journalTitle=中医药学报, columnName=学术探讨, runingTitle=null, highlight=null, articleAbstract=

当前肺癌发病率与死亡率仍居癌症首位,已有的西医治疗手段在不良反应与耐药性上仍存在限制。“肺与大肠相表里”的中医理论在现代医学中与“肺-肠轴”理论相关,已知肠道菌群与短链脂肪酸均与肺癌发生发展有密切联系。本文旨在从短链脂肪酸角度,探讨基于“肺与大肠相表里”理论干预肺癌的可行性和有效性,分析短链脂肪酸在肺癌治疗及预后中的重要性,提出调节肠道短链脂肪酸水平来干预肺癌的新策略,为肺癌的综合治疗与预后改善提供新的思路和方法。

, authors=蒋伶俐, 毛启远, 杨莹, 张根明, 李道睿*, 林洪生, authorsList=蒋伶俐, 毛启远, 杨莹, 张根明, 李道睿, 林洪生, authorCompany=null, correspAuthors=李道睿, authorNote=

蒋伶俐(1999-),女,硕士研究生,研究方向:中西医结合防治肿瘤。

, correspAuthorsNote=
* 李道睿(1979-),男,博士,主任医师,硕士研究生导师,研究方向:中西医结合防治肿瘤。
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蒋伶俐(1999-),女,硕士研究生,研究方向:中西医结合防治肿瘤。

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蒋伶俐(1999-),女,硕士研究生,研究方向:中西医结合防治肿瘤。

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基于“肺与大肠相表里”理论探讨从短链脂肪酸角度调控肺癌
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蒋伶俐 , 毛启远 , 杨莹 , 张根明 , 李道睿 * , 林洪生
中医药学报 | 学术探讨 2026,54(6): 1-5
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中医药学报 |学术探讨 2026 , 54 (6) : 1 -5
基于“肺与大肠相表里”理论探讨从短链脂肪酸角度调控肺癌
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蒋伶俐, 毛启远, 杨莹, 张根明, 李道睿*, 林洪生
作者信息
  • 中国中医科学院广安门医院,北京 100053
通讯作者:
* 李道睿(1979-),男,博士,主任医师,硕士研究生导师,研究方向:中西医结合防治肿瘤。
作者简介:

蒋伶俐(1999-),女,硕士研究生,研究方向:中西医结合防治肿瘤。

Exploration on the Regulation of Lung Cancer through Short-Chain Fatty Acids Based on the Theory of "Lung and Large Intestine Being Internally-Exteriorly Related"
Lingli JIANG, Qiyuan MAO, Ying YANG, Genming ZHANG, Daorui LI*, Hongsheng LIN
Affiliations
  • Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
出版时间: 2026-06-20 doi: 10.19664/j.cnki.1002-2392.260110
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当前肺癌发病率与死亡率仍居癌症首位,已有的西医治疗手段在不良反应与耐药性上仍存在限制。“肺与大肠相表里”的中医理论在现代医学中与“肺-肠轴”理论相关,已知肠道菌群与短链脂肪酸均与肺癌发生发展有密切联系。本文旨在从短链脂肪酸角度,探讨基于“肺与大肠相表里”理论干预肺癌的可行性和有效性,分析短链脂肪酸在肺癌治疗及预后中的重要性,提出调节肠道短链脂肪酸水平来干预肺癌的新策略,为肺癌的综合治疗与预后改善提供新的思路和方法。

肺与大肠相表里  /  短链脂肪酸  /  肺癌

The incidence and mortality rates of lung cancer remain the highest among all cancers. Although advances have been made in Western medical treatments, limitations still exist due to adverse reactions and drug resistance. The Traditional Chinese Medicine (TCM) theory of "the lung and large intestine being interiorly-exteriorly related" is associated with the modern medical concept of the "lung-gut axis. "It is well-established that both gut microbiota and short-chain fatty acids (SCFAs) are closely linked to the occurrence and progression of lung cancer. This study aims to explore the feasibility and effectiveness of intervening in lung cancer based on the "lung and large intestine being interiorly-exteriorly related" theory from the perspective of SCFAs. The importance of SCFAs in lung cancer treatment and prognosis will be analyzed. A new strategy for intervening in lung cancer by regulating intestinal SCFA levels will be proposed, providing new ideas and methods for comprehensive treatment and prognostic improvement of lung cancer.

Lung and large intestine being interiorly-exteriorly related  /  Short-chain fatty acids  /  Lung cancer
蒋伶俐, 毛启远, 杨莹, 张根明, 李道睿, 林洪生. 基于“肺与大肠相表里”理论探讨从短链脂肪酸角度调控肺癌. 中医药学报, 2026 , 54 (6) : 1 -5 . DOI: 10.19664/j.cnki.1002-2392.260110
Lingli JIANG, Qiyuan MAO, Ying YANG, Genming ZHANG, Daorui LI, Hongsheng LIN. Exploration on the Regulation of Lung Cancer through Short-Chain Fatty Acids Based on the Theory of "Lung and Large Intestine Being Internally-Exteriorly Related"[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (6) : 1 -5 . DOI: 10.19664/j.cnki.1002-2392.260110
  • 国家自然科学基金项目(82074405)
  • 中国中医科学院科技创新工程(C12022C002-02)
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doi: 10.19664/j.cnki.1002-2392.260110
  • 接收时间:2025-04-22
  • 首发时间:2026-09-17
  • 出版时间:2026-06-20
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  • 收稿日期:2025-04-22
  • 修回日期:2025-12-11
基金
国家自然科学基金项目(82074405)
中国中医科学院科技创新工程(C12022C002-02)
作者信息
    中国中医科学院广安门医院,北京 100053

通讯作者:

* 李道睿(1979-),男,博士,主任医师,硕士研究生导师,研究方向:中西医结合防治肿瘤。
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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