Article(id=1307269644910355231, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269601637724372, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260108, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1754236800000, receivedDateStr=2025-08-04, revisedDate=1767024000000, revisedDateStr=2025-12-30, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606971242, onlineDateStr=2026-09-17, pubDate=1779206400000, pubDateStr=2026-05-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606971242, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606971242, creator=13701087609, updateTime=1789606971242, updator=13701087609, issue=Issue{id=1307269601637724372, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='5', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1779206400000', pubDateStr='2026-05-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606960925, creator='13701087609', updateTime=1789606960925, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=114, endPage=120, ext={EN=ArticleExt(id=1307269646667768608, articleId=1307269644910355231, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Research Progress on the Regulation of MAPK Signaling Pathway by Traditional Chinese Medicine in the Treatment of Endometriosis, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Endometriosis (EMs) is a chronic inflammatory and estrogen-dependent disease with obvious adverse reactions and a high recurrence rate in clinical treatment. The MAPK signaling pathway plays an important role in the occurrence and development of EMs. Studies have shown that traditional Chinese medicine exhibits the characteristics of multiple targets and multiple mechanisms in the treatment of EMs. It can exert an anti-EMs effect by regulating the MAPK signaling pathway, inhibiting the production of inflammatory factors, promoting cell apoptosis, suppressing abnormal proliferation, migration and invasion of EMs, and inhibiting pathological angiogenesis. This article explored the mechanism of action of active ingredients of traditional Chinese medicine and compound and patent traditional Chinese medicine in treating EMs by regulating the MAPK signaling pathway, with the aim of providing a certain theoretical basis for the prevention and treatment of EMs with traditional Chinese medicine.

, authors=Zhen ZHAO1, Fangyuan LIU2, Fengjuan HAN2, *, authorsList=Zhen ZHAO, Fangyuan LIU, Fengjuan HAN, authorCompany=null, correspAuthors=Fengjuan HAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269647452103458, articleId=1307269644910355231, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=中医药调控MAPK信号通路治疗子宫内膜异位症的研究进展, columnId=1303760941036888710, journalTitle=中医药学报, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

子宫内膜异位症(EMs)是一种慢性炎性、雌激素依赖性疾病,临床治疗不良反应明显、复发率高。MAPK信号通路可在EMs的发生发展过程中发挥重要作用。中医药治疗EMs展现出多靶点、多机制的特点,可通过调控MAPK信号通路,抑制炎症因子产生、促进细胞凋亡、抑制EMs异常增殖、迁移与侵袭、抑制病理性血管生成等,进而发挥抗EMs的作用。本文探讨了中药活性成分、中药复方和中成药,通过调控MAPK信号通路治疗EMs的作用机制,以期为中医药防治EMs提供一定的理论依据。

, authors=赵桢1, 刘芳媛2, 韩凤娟2, *, authorsList=赵桢, 刘芳媛, 韩凤娟, authorCompany=null, correspAuthors=韩凤娟, authorNote=

赵桢(1994-),女,博士研究生,研究方向:中西医结合治疗妇科肿瘤。

, correspAuthorsNote=
* 韩凤娟(1971-),女,博士,教授,主任医师,博士生导师,研究方向:中西医结合治疗妇科肿瘤。
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赵桢(1994-),女,博士研究生,研究方向:中西医结合治疗妇科肿瘤。

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赵桢(1994-),女,博士研究生,研究方向:中西医结合治疗妇科肿瘤。

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中医药调控MAPK信号通路治疗子宫内膜异位症的研究进展
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赵桢 1 , 刘芳媛 2 , 韩凤娟 2, *
中医药学报 | 研究进展 2026,54(5): 114-120
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中医药学报 |研究进展 2026 , 54 (5) : 114 -120
中医药调控MAPK信号通路治疗子宫内膜异位症的研究进展
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赵桢1, 刘芳媛2, 韩凤娟2, *
作者信息
  • 1.黑龙江中医药大学,黑龙江 哈尔滨 150040
  • 2.黑龙江中医药大学附属第一医院,黑龙江 哈尔滨 150040
通讯作者:
* 韩凤娟(1971-),女,博士,教授,主任医师,博士生导师,研究方向:中西医结合治疗妇科肿瘤。
作者简介:

赵桢(1994-),女,博士研究生,研究方向:中西医结合治疗妇科肿瘤。

Research Progress on the Regulation of MAPK Signaling Pathway by Traditional Chinese Medicine in the Treatment of Endometriosis
Zhen ZHAO1, Fangyuan LIU2, Fengjuan HAN2, *
Affiliations
  • 1.Heilongjiang University of Chinese Medicine, Harbin 150040, China
  • 2.The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China
出版时间: 2026-05-20 doi: 10.19664/j.cnki.1002-2392.260108
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子宫内膜异位症(EMs)是一种慢性炎性、雌激素依赖性疾病,临床治疗不良反应明显、复发率高。MAPK信号通路可在EMs的发生发展过程中发挥重要作用。中医药治疗EMs展现出多靶点、多机制的特点,可通过调控MAPK信号通路,抑制炎症因子产生、促进细胞凋亡、抑制EMs异常增殖、迁移与侵袭、抑制病理性血管生成等,进而发挥抗EMs的作用。本文探讨了中药活性成分、中药复方和中成药,通过调控MAPK信号通路治疗EMs的作用机制,以期为中医药防治EMs提供一定的理论依据。

子宫内膜异位症  /  MAPK信号通路  /  中医药  /  研究进展

Endometriosis (EMs) is a chronic inflammatory and estrogen-dependent disease with obvious adverse reactions and a high recurrence rate in clinical treatment. The MAPK signaling pathway plays an important role in the occurrence and development of EMs. Studies have shown that traditional Chinese medicine exhibits the characteristics of multiple targets and multiple mechanisms in the treatment of EMs. It can exert an anti-EMs effect by regulating the MAPK signaling pathway, inhibiting the production of inflammatory factors, promoting cell apoptosis, suppressing abnormal proliferation, migration and invasion of EMs, and inhibiting pathological angiogenesis. This article explored the mechanism of action of active ingredients of traditional Chinese medicine and compound and patent traditional Chinese medicine in treating EMs by regulating the MAPK signaling pathway, with the aim of providing a certain theoretical basis for the prevention and treatment of EMs with traditional Chinese medicine.

Endometriosis  /  MAPK signal pathway  /  Traditional Chinese medicine  /  Research progress
赵桢, 刘芳媛, 韩凤娟. 中医药调控MAPK信号通路治疗子宫内膜异位症的研究进展. 中医药学报, 2026 , 54 (5) : 114 -120 . DOI: 10.19664/j.cnki.1002-2392.260108
Zhen ZHAO, Fangyuan LIU, Fengjuan HAN. Research Progress on the Regulation of MAPK Signaling Pathway by Traditional Chinese Medicine in the Treatment of Endometriosis[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (5) : 114 -120 . DOI: 10.19664/j.cnki.1002-2392.260108
  • 中医药循证能力提升项目(国中医药科技中药便函〔2023〕24号)
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2026年第54卷第5期
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doi: 10.19664/j.cnki.1002-2392.260108
  • 接收时间:2025-08-04
  • 首发时间:2026-09-17
  • 出版时间:2026-05-20
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  • 收稿日期:2025-08-04
  • 修回日期:2025-12-30
基金
中医药循证能力提升项目(国中医药科技中药便函〔2023〕24号)
作者信息
    1.黑龙江中医药大学,黑龙江 哈尔滨 150040
    2.黑龙江中医药大学附属第一医院,黑龙江 哈尔滨 150040

通讯作者:

* 韩凤娟(1971-),女,博士,教授,主任医师,博士生导师,研究方向:中西医结合治疗妇科肿瘤。
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2种不同金属材料的力学参数

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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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