Article(id=1307269617055985977, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269601637724372, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260106, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1740672000000, receivedDateStr=2025-02-28, revisedDate=1773849600000, revisedDateStr=2026-03-19, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606964600, onlineDateStr=2026-09-17, pubDate=1779206400000, pubDateStr=2026-05-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606964600, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606964600, creator=13701087609, updateTime=1789606964600, updator=13701087609, issue=Issue{id=1307269601637724372, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='5', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1779206400000', pubDateStr='2026-05-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606960925, creator='13701087609', updateTime=1789606960925, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=104, endPage=108, ext={EN=ArticleExt(id=1307269617215369530, articleId=1307269617055985977, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Clinical Observation of the Treatment of Chronic Hepatitis B with Liver Stagnation, Spleen Deficiency, and Blood Stasis Obstructing the Collaterals by Modified Yanggan Powder Combined with Si Ni Powder, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the clinical efficacy of modified Yanggan Powder combined with Sini Powder in the treatment of chronic hepatitis B (CHB) with liver depression, spleen deficiency, and blood stasis obstructing the collaterals.
Methods: A total of 122 CHB patients diagnosed in the Hai'an Traditional Chinese Medicine Hospital from April 2021 to December 2023 were randomly divided into an observation group (n=61) and a control group (n = 61) using a computer-generated random number method. The control group was treated with entecavir, while the observation group received a combination of modified Yanggan Powder and Sini Powder. After 6 months of treatment, the two groups were compared for TCM syndrome scores, liver function, HBV-DNA load, inflammatory factors (IL-1β, IL-6), liver function ultrasound indicators, therapeutic efficacy, and adverse reactions.
Results: After treatment, both groups showed a reduction in TCM syndrome scores, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBiL), HBV-DNA load, IL-1β, and IL-6, with the observation group showing lower values than the control group (P <0.05). Both groups had an increase in albumin (ALB), with the observation group showing a higher increase than the control group. There were no significant changes in the hepatic portal vein diameter, splenic vein diameter, or spleen thickness before and after treatment in both groups (P > 0.05). The therapeutic efficacy rate in the observation group was higher than that in the control group (P <0.05). No serious adverse reactions were observed in either group.
Conclusion: Modified Yanggan Powder combined with Sini Powder is effective in treating HBV with liver qi stagnation, spleen deficiency, and blood stasis obstructing the channels, helping to relieve liver function symptoms, reduce inflammatory responses, and achieve good therapeutic effects.
, authors=Zhaoyun WANG, Guangquan ZHOU, authorsList=Zhaoyun WANG, Guangquan ZHOU, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269617643188539, articleId=1307269617055985977, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=养肝散合四逆散加减方治疗慢性乙型肝炎肝郁脾虚兼瘀血阻络证的临床观察, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探讨养肝散合四逆散加减方治疗慢性乙型肝炎（CHB）肝郁脾虚兼瘀血阻络证的临床效果。
方法： 选取2021年4月—2023年12月海安市中医院接诊的CHB患者122例，采用电脑随机数字表法分为观察组和对照组，每组61例。对照组给予恩替卡韦治疗，观察组联合养肝散合四逆散加减方治疗。治疗6个月后，比较两组的中医证候评分、肝功能、HBV-DNA载量、炎症因子［白细胞介素-1β （IL-1β）、IL-6］、肝功能超声指标、临床疗效及不良反应。
结果： 治疗后，两组中医证候评分、天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、总胆红素（TBiL）、HBV-DNA载量、IL-1β、IL-6均降低（P < 0.05），且观察组低于对照组（P < 0.05）。两组白蛋白（ALB）升高（P < 0.05），观察组高于对照组（P < 0.05）。治疗前后，观察组和对照组的肝门静脉主干内径、脾静脉内径、脾脏厚度无明显变化（P > 0.05）。观察组治疗有效率高于对照组（P < 0.01）。两组未见严重不良反应。
结论： 养肝散合四逆散加减方治疗肝郁脾虚兼瘀血阻络证CHB，有助于缓解患者的肝功能症状，减轻炎症反应，疗效良好。
, authors=王赵云, 周广泉, authorsList=王赵云, 周广泉, authorCompany=null, correspAuthors=null, authorNote=
王赵云（1989-），男，硕士，主治中医师，从事消化系统疾病相关研究。
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王赵云（1989-），男，硕士，主治中医师，从事消化系统疾病相关研究。
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王赵云（1989-），男，硕士，主治中医师，从事消化系统疾病相关研究。
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