Article(id=1307269618024862211, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269601637724372, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260104, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1733673600000, receivedDateStr=2024-12-09, revisedDate=1760112000000, revisedDateStr=2025-10-11, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606964832, onlineDateStr=2026-09-17, pubDate=1779206400000, pubDateStr=2026-05-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606964832, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606964832, creator=13701087609, updateTime=1789606964832, updator=13701087609, issue=Issue{id=1307269601637724372, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='5', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1779206400000', pubDateStr='2026-05-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606960925, creator='13701087609', updateTime=1789606960925, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=93, endPage=98, ext={EN=ArticleExt(id=1307269619690000900, articleId=1307269618024862211, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Efficacy of Shufeng Zhisou Decoction Combined with Montelukast Sodium on Patients with Cough Variant Asthma, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To observe the efficacy of Shufeng Zhisou Decoction combined with montelukast sodium in the treatment of patients with cough variant asthma (CVA) and its influence on the airway inflammatory factors levels, pulmonary function and T lymphocyte immune balance.
Methods: 104 CVA patients with pattern of wind pathogen attacking the lung were selected from September 2023 to July 2024 in Beijing Hepingli Hospital, and were divided into western medicine group (montelukast sodium on the basis of routine treatment) and combined group (Shufeng Zhisou Decoction on the basis of Western medicine group) according to the random number table method, 52 cases in each group. The clinical efficacy, TCM symptoms scores, airway inflammatory factors [fractional exhaled nitric oxide (FeNO), sputum eosinophil (EOS), sputum eosinophil cationic protein (ECP)], pulmonary function [forced vital capacity (FVC), peak expiratory flow (PEF), forced expiratory volume in the first second as a percentage of predicted value (FEV1)] and T lymphocyte immune balance [interleukin-4 (IL-4), interferon-γ (IFN-γ), IFN-γ/IL-4] before and after treatment, adverse reactions and recurrence rate within 1 months of follow-up were compared between groups.
Results: The combined group had higher total effective rate of treatment (90.38% vs 75.00%) than the Western medicine group (P <0.05). After treatment, the scores of cough, expectoration and pharyngeal pruritus in the two groups were decreased (P <0.05), and the scores in combined group [(0.60 ± 0.11) points vs(0.84 ± 0.14) points]、[(0.64 ± 0.11) points vs(0.87 ± 0.14) points]、[(0.68 ± 0.12) points vs(0.79 ± 0.14) points] were lower after treatment (P <0.05). The levels of FeNO, sputum EOS, ECP and serum IL-4 were reduced in both groups after treatment (P <0.05), FVC, PEF, FEV1, IFN-γ and IFN-γ/IL-4 in the two groups were enhanced (P <0.05), and there were statistical differences between groups after treatment (P <0.05).
Conclusion: Shufeng Zhisou Decoction combined with montelukast sodium can effectively improve the clinical symptoms and pulmonary function of CVA, relieve the airway inflammation, regulate the T lymphocyte immune imbalance, and improve the prognosis.
, authors=Qiu ZHANG, Yan LI, Ping WANG, authorsList=Qiu ZHANG, Yan LI, Ping WANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269620038128133, articleId=1307269618024862211, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=疏风止嗽汤联合孟鲁司特钠治疗咳嗽变异性哮喘患者的疗效, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 观察疏风止嗽汤联合孟鲁司特钠治疗咳嗽变异性哮喘（CVA）患者疗效及对气道炎症因子水平、肺功能和T淋巴细胞免疫平衡的影响。
方法： 选取2023年9月—2024年7月北京市和平里医院收治的104例风邪犯肺证CVA患者，按照随机数字表法分为西药组（在常规治疗基础上给予孟鲁司特钠治疗）和联合组（在西药组基础上联合疏风止嗽汤治疗），每组52例。比较两组患者临床疗效，治疗前后中医症状积分、气道炎症因子水平［呼出气一氧化氮（FeNO）、痰液嗜酸性粒细胞（EOS）、痰液嗜酸性粒细胞阳离子蛋白（ECP）］、肺功能［用力肺活量（FVC）、呼气峰流量（PEF）、第1秒用力呼气容积占预计百分比（FEV1）］、T淋巴细胞免疫平衡［白细胞介素-4（IL-4）、干扰素-γ（IFN-γ）、IFN-γ/IL-4］及不良反应、随访1个月内复发率。
结果： 联合组治疗总有效率为90.38% （47/52），高于西药组的75%（39/52），两组比较差异有统计学意义（P < 0.05）；治疗后，两组咳嗽、咳痰、咽痒评分均下降（P < 0.05），且治疗后联合组低于西药组（P < 0.05）；治疗后，两组FeNO、痰液EOS、ECP与血清IL-4水平均下降（P < 0.05），FVC、PEF、FEV1、IFN-γ、IFN-γ/IL-4均升高（P < 0.05），且治疗后组间比较，差异具有统计学意义（P < 0.05）。
结论： 疏风止嗽汤联合孟鲁司特钠可有效改善CVA临床症状和肺功能，缓解气道炎症，调节T淋巴细胞免疫失衡，改善预后。
, authors=张秋, 李研, 王萍, authorsList=张秋, 李研, 王萍, authorCompany=null, correspAuthors=null, authorNote=
张秋（1981-），男，硕士，主治医师，主要从事中医药防治呼吸系统疾病研究。
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张秋（1981-），男，硕士，主治医师，主要从事中医药防治呼吸系统疾病研究。
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