Article(id=1307269606939316647, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269601637724372, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260098, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1739980800000, receivedDateStr=2025-02-20, revisedDate=1764777600000, revisedDateStr=2025-12-04, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606962188, onlineDateStr=2026-09-17, pubDate=1779206400000, pubDateStr=2026-05-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606962188, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606962188, creator=13701087609, updateTime=1789606962188, updator=13701087609, issue=Issue{id=1307269601637724372, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='5', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1779206400000', pubDateStr='2026-05-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606960925, creator='13701087609', updateTime=1789606960925, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=63, endPage=67, ext={EN=ArticleExt(id=1307269607128060328, articleId=1307269606939316647, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Study on the Clinical Effect and Prognostic Factors of Acupuncture Intervention Based on Meridian Flow Theory in Comatose Patients with Severe Craniocerebral Injury, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the mechanism of promoting awakening effect and prognosis of coma patients with severe craniocerebral injury based on meridian flow theory combined with acupuncture.
Methods: A total of 102 coma patients with severe craniocerebral injury admitted to Xinxiang Central Hospital from October 2021 to October 2024 were divided into observation group and control group. The control group was given routine intervention. On the basis of the control group, the observation group was given meridian flow theory combined with acupuncture treatment. The waking time, waking rate, GCS and FOUR scores and prognosis were compared between the two groups. The levels of neuron-specific enolase (NSE), S100B protein (S-100B) and myelin basic protein (MBP) were compared between the two groups before and after treatment. The improvement of cerebral blood flow (CBF) and cerebral blood volume (CBV) before and after treatment was compared between the two groups.
Results: The awakening rate of observation group was 82.35% higher than that of control group 64.71%, and the awakening time was significantly lower than that of control group (P <0.05). After 10 and 30 days of treatment, GCS and FOUR scores of both groups significantly increased, and the observation group was significantly higher than the control group (P <0.05) ; After treatment, NSE, S-100B and MBP significantly decreased in both groups, and the observation group was significantly lower than the control group (P < 0.05). After treatment, CBF and CBV significantly increased in both groups, and the observation group was significantly higher than the control group (P <0.05). Compared with 68.63% of the control group, the total effective rate of the observation group was 86.27% (P < 0.05).
Conclusion: Acupuncture combined with meridian injection theory can significantly improve the awakening rate of coma patients with severe craniocerebral injury, improve nerve function and cerebral blood flow indexes, and the prognostic effect is better than conventional treatment.
, authors=Rui WANG, Xudong SUN, Zimin HOU
*, authorsList=Rui WANG, Xudong SUN, Zimin HOU, authorCompany=null, correspAuthors=Zimin HOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269608013058473, articleId=1307269606939316647, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=基于子午流注理论联合针刺对重型颅脑损伤昏迷患者促醒效果及预后影响机制研究, columnId=1303760931671011820, journalTitle=中医药学报, columnName=针灸经络, runingTitle=null, highlight=null, articleAbstract=
目的： 探究基于子午流注理论联合针刺对重型颅脑损伤昏迷患者促醒效果及预后影响。
方法： 选取2021年10月—2024年10月新乡市中心医院收治的102例重型颅脑损伤昏迷患者，随机分为观察组和对照组，每组51例。对照组给予常规干预。观察组在对照组的基础上给予子午流注理论联合针刺治疗。对比两组促醒时间、促醒率、格拉斯哥昏迷量表（GCS）和全面无反应性量表（FOUR）评分及预后效果；对比两组治疗前后神经元特异性烯醇化酶（NSE）、S100B蛋白（S-100B）和髓鞘碱性蛋白（MBP）水平；对比两组治疗前后脑血流量（CBF）和脑血容量（CBV）改善状况。
结果： 观察组促醒率为82.35% （42/51）明显高于对照组的64.71% （33/51），差异有统计学意义（P < 0.05），且促醒时长明显低于对照组（P < 0.01）；治疗10 d、30 d后，两组GCS、FOUR评分均显著升高（P < 0.05），且观察组明显高于对照组（P < 0.01）；治疗后，两组NSE、S-100B、MBP均显著降低（P < 0.05），且观察组明显低于对照组（P <0.01）；治疗后两组CBF、CBV均显著升高（P < 0.05），且观察组明显高于对照组（P < 0.01）；与对照组总有效率68.63% （35/51）相比，观察组总有效率86.27% （44/51）明显更高（P < 0.05）。
结论： 基于子午流注理论联合针刺治疗可显著提高重型颅脑损伤昏迷患者促醒率，改善神经功能、脑血流指标，预后效果优于常规治疗。
, authors=王睿, 孙旭东, 侯子旻
*, authorsList=王睿, 孙旭东, 侯子旻, authorCompany=null, correspAuthors=侯子旻, authorNote=
王睿（1985-），女，主治医师，从事中西医结合颅脑损伤治疗工作。
, correspAuthorsNote=
* 侯子旻（1990-），男，主治医师，从事脑损伤的重症康复工作。
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王睿（1985-），女，主治医师，从事中西医结合颅脑损伤治疗工作。
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王睿（1985-），女，主治医师，从事中西医结合颅脑损伤治疗工作。
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