Article(id=1307269621086712147, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269601637724372, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260091, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1765468800000, receivedDateStr=2025-12-12, revisedDate=1773763200000, revisedDateStr=2026-03-18, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606965562, onlineDateStr=2026-09-17, pubDate=1779206400000, pubDateStr=2026-05-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606965562, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606965562, creator=13701087609, updateTime=1789606965562, updator=13701087609, issue=Issue{id=1307269601637724372, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='5', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1779206400000', pubDateStr='2026-05-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606960925, creator='13701087609', updateTime=1789606960925, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=20, endPage=27, ext={EN=ArticleExt(id=1307269621275455828, articleId=1307269621086712147, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Analysis of the Distribution Patterns of "Disease-Syndrome-Symptom-Laboratory Indicators" in 2,113 Patients with Diabetes Mellitus Complicated by Osteoporosis, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the distribution of clinical characteristics and traditional Chinese medicine (TCM) syndrome patterns in patients with diabetes mellitus complicated with osteoporosis (DM-OP), and to explore the associations between TCM syndromes and laboratory indicators, so as to elucidate the intrinsic patterns of the "disease-syndrome-symptom-laboratory indicator" relationship.
Methods: Retrospectively collected medical records of patients with diabetes complicated by osteoporosis who were hospitalized in the Department of Endocrinology at Guang'anmen Hospital, China Academy of Chinese Medical Sciences, from January 1, 2015 to December 31, 2024. The distribution of TCM syndrome patterns was analyzed, and the associations between different syndromes and general characteristics, comorbidities, symptom profiles, tongue and pulse features, bone mineral density, and laboratory indicators were explored.
Results: Among patients with DM-OP, spleen-kidney deficiency syndrome was the most common pattern, followed by liver-kidney yin deficiency syndrome, damp-heat accumulation syndrome, and spleen-stomach qi deficiency syndrome. Significant differences were observed among different TCM syndromes in terms of age, body mass index (BMI), blood pressure, comorbidities, certain symptoms and tongue-pulse features, femoral neck bone mineral density, and selected laboratory indicators. Patients with spleen-stomach qi deficiency syndrome were relatively younger and had higher BMI, whereas those with liver-kidney yin deficiency syndrome and spleen-kidney deficiency syndrome were older, had lower femoral neck bone mineral density, and showed higher incidences of fractures and chronic kidney disease.
Conclusion: The distribution of TCM syndromes in DM-OP reflects a progressive pathomechanism involving the spleen and kidney. Different TCM syndromes exhibit distinct characteristics in clinical manifestations, comorbidities, bone mineral density, and laboratory indicators.
, authors=Yang ZHOU
1, 2, Weili TAN
1, 2, Zifan ZHUANG
1, 2, Xinyao LIU
2, Haochen KANG
2, Jingbo LIU
3, Qing NI
2, *, authorsList=Yang ZHOU, Weili TAN, Zifan ZHUANG, Xinyao LIU, Haochen KANG, Jingbo LIU, Qing NI, authorCompany=null, correspAuthors=Qing NI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269621661331798, articleId=1307269621086712147, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=2 113例糖尿病合并骨质疏松症患者的“病-证-症-检验指标”分布规律分析, columnId=1307269621363536213, journalTitle=中医药学报, columnName=思路与方法, runingTitle=null, highlight=null, articleAbstract=
目的： 研究糖尿病合并骨质疏松症（DM-OP）患者的临床特征分布及中医证型与实验室指标的相关性，揭示其“病-证-症-检验指标”的内在规律。
方法： 回顾性收集2015年1月1日—2024年12月31日于中国中医科学院广安门医院内分泌科住院治疗的糖尿病合并骨质疏松症患者病历资料，分析DM-OP证型分布规律，并探究中医证型与患者的一般情况、合并疾病、症状舌脉特征、骨密度及实验室检验的相关性。
结果： DM-OP患者以脾肾两虚证为主，其次为肝肾阴虚证、湿热内蕴证及脾胃气虚证。不同证型患者在年龄、BMI、血压、合并疾病、部分症状舌脉特征、股骨颈骨密度及部分实验室指标方面存在差异（P < 0.05，P < 0.01）。其中脾胃气虚证患者年龄相对较小、BMI较高；肝肾阴虚证及脾肾两虚证患者年龄偏大，股骨颈骨密度较低，骨折及慢性肾病发生率较高。
结论： DM-OP证候分布呈现由脾及肾的病机演变。不同证型在临床表现、合并疾病、骨密度及检验指标方面具有一定特征性。
, authors=周扬
1, 2, 谭伟丽
1, 2, 庄子凡
1, 2, 刘馨谣
2, 康浩宸
2, 刘晶波
3, 倪青
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周扬（1997-），女，博士研究生，从事内分泌代谢病的中医药诊疗研究。
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* 倪青（1968-），男，博士，主任医师，博士生导师，从事内分泌代谢病的中医药诊疗研究。
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