Article(id=1307269625608168055, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269601637724372, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260090, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1762963200000, receivedDateStr=2025-11-13, revisedDate=1774454400000, revisedDateStr=2026-03-26, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606966640, onlineDateStr=2026-09-17, pubDate=1779206400000, pubDateStr=2026-05-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606966640, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606966640, creator=13701087609, updateTime=1789606966640, updator=13701087609, issue=Issue{id=1307269601637724372, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='5', pageStart='1', pageEnd='126', issueExtLink='null', onlineDate='null', pubDate='1779206400000', pubDateStr='2026-05-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606960925, creator='13701087609', updateTime=1789606960925, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=14, endPage=19, ext={EN=ArticleExt(id=1307269625775940216, articleId=1307269625608168055, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effects and Potential Mechanisms of Buxu Xiaoke Mixture Combined with Pyrroloquinoline Quinone in Rats with Type 2 Diabetes Mellitus, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the pharmacodynamic effects of Buxu Xiaoke Mixture combined with pyrroloquinoline quinone (PQQ) on type 2 diabetes mellitus (T2DM) rats and analyze its possible mechanism of action.
Methods: A T2DM rat model was established. Rats in the positive group, 1/4 Buxu Xiaoke Mixture + PQQ group, 1/2 Buxu Xiaoke Mixture + PQQ group, full-dose Buxu Xiaoke Mixture + PQQ group, Buxu Xiaoke Mixture group, and PQQ group were administered for 12 weeks. Blood glucose, urine volume, body weight, food intake, and water intake of rats were detected. ELISA was used to detect blood glucose, blood lipids, oxidative stress, and inflammatory factor-related indicators in rat serum, while HE staining was applied to observe pathological changes in kidney and pancreas tissues.
Results: In the full-dose Buxu Xiaoke Mixture + PQQ group, the FINS level was increased (P <0.01), the HOMA-β level was increased (P < 0.05), the GSP and HOMA-IR levels were decreased (P < 0.01), the TG, TC and LDL-C levels were decreased (P < 0.01), the HDL-C level was increased (P < 0.01), the MDA level was decreased (P <0.01), the SOD and GSH-Px levels were increased (P <0.01), and the IL-1and TNF-α levels were decreased (P <0.01). This treatment could significantly improve glucose and lipid metabolism, inflammation and oxidative stress in rats, alleviate kidney and pancreatic tissue damage, with a better efficacy than monotherapy and a dose-dependent effect. Analysis showed that the mechanism of action may involve pathways related to inflammation and oxidative stress in T2DM.
Conclusion: The combination of full-dose Buxu Xiaoke Mixture and PQQ can synergistically improve T2DM via multi-targets by increasing GSP and decreasing MDA, TG levels, and the mechanism of action may be related to inhibiting oxidative stress and inflammatory response.
, authors=Xinyue ZHANG
1, Tianyu WANG
1, Chenyue DING
1, Ping WANG
2, Jiarong HUO
1, Xingang JIANG
3, Xiuhong WU
1, *, authorsList=Xinyue ZHANG, Tianyu WANG, Chenyue DING, Ping WANG, Jiarong HUO, Xingang JIANG, Xiuhong WU, authorCompany=null, correspAuthors=Xiuhong WU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269626153427577, articleId=1307269625608168055, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=补虚消渴合剂联合吡咯喹啉醌治疗2型糖尿病大鼠的作用及潜在机制研究, columnId=1303760926633652690, journalTitle=中医药学报, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探究补虚消渴合剂联合吡咯喹啉醌（PQQ）对2型糖尿病（T2DM）大鼠的药效作用，分析其可能的作用机制。
方法： 80只大鼠随机分为8组，分别为空白组、模型组、阳性组、1/4补虚消渴合剂+PQQ组、1/2补虚消渴合剂+PQQ组、全剂量补虚消渴合剂+PQQ组、补虚消渴合剂组、PQQ组，采用高脂饮食联合腹腔注射链脲佐菌素（STZ）的方法建立T2DM大鼠模型，空白组与模型组灌胃等量生理盐水，其他组给予对应药物12周，检测大鼠血糖、尿量、体质量、摄食量及饮水量。ELISA检测大鼠血清中血糖、血脂、氧化应激及炎症因子相关指标，HE染色观察肾脏、胰腺组织病理变化。
结果： 与模型组相比，全剂量补虚消渴合剂+PQQ组FINS水平升高（P < 0.01），HOMA-β水平升高（P < 0.05），GSP、HOMA-IR水平降低（P < 0.01），TG、TC、LDL-C水平降低（P < 0.01），HDL-C水平升高（P < 0.01），MDA水平降低（P < 0.01），SOD、GSH-Px水平升高（P < 0.01），IL-1、TNF-α水平降低（P < 0.01），能够显著改善大鼠糖脂代谢、炎症及氧化应激，减轻肾脏、胰腺组织损伤，效果优于单一用药且具剂量依赖性。分析其作用机制可能涉及T2DM炎症、氧化应激等相关通路。
结论： 补虚消渴合剂联合PQQ可通过升高GSP及降低MDA、TG含量多靶点协同改善T2DM，作用机制可能与抑制氧化应激及炎症反应有关。
, authors=张歆悦
1, 王天宇
1, 丁晨悦
1, 王萍
2, 霍佳荣
1, 姜新刚
3, 吴修红
1, *, authorsList=张歆悦, 王天宇, 丁晨悦, 王萍, 霍佳荣, 姜新刚, 吴修红, authorCompany=null, correspAuthors=吴修红, authorNote=
张歆悦（2000-），女，硕士研究生，研究方向：中药药效物质基础发现及质量评价研究。
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* 吴修红（1978-），女，博士，教授，博士生导师，研究方向：中药药效物质基础发现及质量评价研究。
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