Article(id=1307269656906068595, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1307269637637427792, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260084, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1734624000000, receivedDateStr=2024-12-20, revisedDate=1765728000000, revisedDateStr=2025-12-15, acceptedDate=null, acceptedDateStr=null, onlineDate=1789606974102, onlineDateStr=2026-09-17, pubDate=1776614400000, pubDateStr=2026-04-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1789606974102, onlineIssueDateStr=2026-09-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1789606974102, creator=13701087609, updateTime=1789606974102, updator=13701087609, issue=Issue{id=1307269637637427792, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='4', pageStart='1', pageEnd='127', issueExtLink='null', onlineDate='null', pubDate='1776614400000', pubDateStr='2026-04-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1789606969508, creator='13701087609', updateTime=1789606969508, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=101, endPage=105, ext={EN=ArticleExt(id=1307269657057063540, articleId=1307269656906068595, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Study on the Effects of Modified Dingchuan Decoction on Efficacy, EOS, and SAA Levels in Children with Cough Variant Asthma Phlegm-Heat Accumulation in the Lung Syndrome, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the efficacy of modified Dingchuan Decoction in treating children with cough variant asthma (CVA) of phlegm-heat accumulation in the lung syndrome and its effects on eosinophil (EOS) and serum amyloid A (SAA) levels.
Methods: From June 2021 to June 2024, a total of 104 children diagnosed with CVA (Phlegm-Heat Accumulation in the Lung Syndrome) who received treatment at Huai'an Traditional Chinese Medicine Hospital were randomly assigned into two groups: an observation group comprising 52 cases and a control group also consisting of 52 cases, with the assignment process conducted using a random number table method. The control group received a therapeutic regimen consisting of budesonide suspension administered via inhalation, complemented by montelukast sodium chewable tablets taken orally, while the observation group was treated with modified Dingchuan Decoction. After 1 week of treatment, traditional Chinese medicine syndrome scores, inflammatory factors (EOS and SAA), immune indicators (CD3+, CD4+, and CD8+), pulmonary function indices (FEV1 and FVC), clinical efficacy, and adverse reactions were compared between the two groups.
Results: After treatment, traditional Chinese medicine syndrome scores, EOS, SAA, and CD8+ levels in the observation group and the control group decreased, with the observation group showing lower levels than the control group (P < 0.05). The CD3+, CD4+, FEV1, and FVC levels in both groups increased compared to before treatment (P <0.05). The observation group had higher levels than the control group (P <0.05). The treatment efficacy rate in the observation group was higher than that in the control group (P <0.05). During the treatment, no severe adverse reactions were observed in either group.
Conclusion: The modified Dingchuan Decoction is effective in treating children with CVA, which helps to suppress airway inflammation and improve the anti asthmatic effect of children, with good safety.
, authors=Yan ZHU, Ling HU, Nan SUN
*, authorsList=Yan ZHU, Ling HU, Nan SUN, authorCompany=null, correspAuthors=Nan SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1307269657396802165, articleId=1307269656906068595, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=定喘汤加减治疗对咳嗽变异性哮喘(痰热蕴肺证)患儿疗效、EOS、SAA水平的影响研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探讨定喘汤加减治疗咳嗽变异性哮喘（CVA）痰热蕴肺证患儿的疗效及对嗜酸性粒细胞（EOS）、淀粉样蛋白A（SAA）水平的影响。
方法： 选取2021年6月—2024年6月在淮安市中医院接受治疗的CVA（痰热蕴肺证）患儿104例，采用随机数字表法分为观察组和对照组，每组52例，对照组吸入布地奈德混悬液、口服孟鲁司特钠咀嚼片治疗，观察组加用定喘汤加减治疗。治疗1周后，比较两组的中医证候评分、炎症因子（EOS、SAA）、免疫指标（CD3+、CD4+、CD8+）、肺功能（FEV1、FVC）、临床疗效及不良反应。
结果： 治疗后，观察组和对照组的中医证候评分、EOS、SAA、CD8+降低（P <0.05），观察组低于对照组（P <0.05）。观察组和对照组的CD3+、CD4+、FEV1、FVC较治疗前升高（P <0.05），观察组高于对照组（P <0.05）。观察组治疗有效率高于对照组（P <0.05）。治疗期间，两组未见严重不良反应。
结论： 定喘汤加减治疗CVA患儿，有助于抑制气道炎症反应，提高患儿的平喘效果，安全性良好。
, authors=朱燕, 胡玲, 孙南
*, authorsList=朱燕, 胡玲, 孙南, authorCompany=null, correspAuthors=孙南, authorNote=
朱燕（1990-），女，主治中医师，从事中医儿科相关研究。
, correspAuthorsNote=
* 孙南（1982-），女，硕士，副主任中医师，从事中医儿科相关研究。
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朱燕（1990-），女，主治中医师，从事中医儿科相关研究。
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朱燕（1990-），女，主治中医师，从事中医儿科相关研究。
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