中医药学报

黄连温胆汤化裁治疗小儿多发性抽动症(痰热动风证)的临床研究

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张郭莹 ¹ , 卫妍 ¹ , 黎彦麟 ¹ , 凌露 ¹ , 何磊 ²^,^*

中医药学报 | 临床研究 2026,54(4): 84-88

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中医药学报 |临床研究 2026 , 54 (4) : 84 -88

黄连温胆汤化裁治疗小儿多发性抽动症(痰热动风证)的临床研究

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张郭莹¹, 卫妍¹, 黎彦麟¹, 凌露¹, 何磊²^,^*

作者信息

^1.南京中医药大学南通附属医院，江苏南通 226001

^2.南通瑞慈医院，江苏南通 226010

通讯作者:

^* 何磊（1992-），男，主治中医师，研究方向：儿童神经及呼吸道疾病防治。

作者简介:

张郭莹（1991-），女，主治中医师，研究方向：儿童神经及儿童内分泌疾病诊治。

Clinical Study on Modified Huanglian Wendan Decoction in the Treatment of Pediatric Multiple Tic Disorder (Phlegm-Heat Stirring Wind Syndrome)

Guoying ZHANG¹, Yan WEI¹, Yanlin LI¹, Lu LING¹, Lei HE²^,^*

Affiliations

^1.Nantong Affiliated Hospital of Nanjing University of Chinese Medicine, Nantong 226001, China

^2.Nantong Ruici Hospital, Nantong 226010, China

出版时间: 2026-04-20 doi: 10.19664/j.cnki.1002-2392.260081

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摘要

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目的：

探讨黄连温胆汤化裁对小儿痰热动风证多发性抽动症（TS）的临床治疗效果。

方法：

选取2024年1月—2024年10月于南京中医药大学南通附属医院进行诊治的TS患儿112例，随机分为观察组和对照组，各56例。治疗期间嘱患儿规律作息、合理饮食，保持良好的情绪状态，避免不良刺激。所有患儿均给予耳穴压豆疗法。对照组在此基础上给予硫必利片口服，观察组则给予黄连温胆汤化裁水煎服，所有患儿连续治疗8周。记录并比较两组治疗前、治疗2周以及治疗8周后的病情改善情况、中医证候积分以及血清多巴胺（DA）、γ-氨基丁酸（GABA）、去甲肾上腺素（NE）水平。比较两组患儿治疗8周后临床疗效。

结果：

治疗前，两组患儿耶鲁综合抽动严重程度量表（YGTSS）评分、中医证候积分以及血清DA、GABA、NE水平差异无统计学意义（P >0.05），治疗2周、8周后两组YGTSS评分、中医证候积分以及血清DA水平降低（P <0.05），GABA、NE水平升高（P <0.05），且两组间各时点比较观察组更佳（P <0.05）。治疗8周后，观察组总有效率92.86% （52/56）高于对照组73.21% （41/56），差异有统计学意义（P <0.05）。

结论：

黄连温胆汤化裁可以有效改善痰热动风型TS患儿抽动症状，缓解患儿中医症状，降低血清DA水平，临床疗效显著。

关键词

黄连温胆汤 / 多发性抽动症 / 小儿 / 痰热动风证 / 临床疗效

Abstract

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Objective:

To observe the clinical efficacy of Huanglian Wendan Decoction in the treatment of pediatric multiple tic disorder (phlegm-heat-driven wind evidence).

Methods:

The selected research subjects were 112 children with TS who were diagnosed and treated in Nantong Traditional Chinese Medicine Hospital from January 2024 to October 2024, and were randomly divided into an observation group and a control group with 56 cases each. During the treatment period, the children were instructed to have a regular schedule, eat properly, maintain a good emotional state, and avoid adverse stimuli. All children were given ear acupoint pressure bean therapy. On this basis, the control group was given oral tiapride tablets, while the observation group was given Huanglian Wendan Decoction in water. All children were treated continuously for 8 weeks. The condition improvement, TCM syndrome scores and serum dopamine (DA), Gamma-aminobutyric acid (GABA), norepinephrine (NE) levels before treatment, 2 weeks of treatment and 8 weeks of treatment were recorded and compared between the two groups. Compare the clinical efficacy of the two groups of children after 8 weeks of treatment.

Results:

Before treatment, there was no difference in YGTSS scores, TCM evidence points and serum DA, GABA, NE levels between the two groups of children (P >0.05). after 2 weeks and 8 weeks of treatment, the YGTSS scores, TCM syndrome integral and serum DA level of the two groups decreased, while the GABA and NE levels increased. And at each time point, the observation group was better than the control group. (P <0.05). After 8 weeks of treatment, the total effective rate was 92.86% (52/56) higher in the observation group than 73.21% (41/56) in the control group (P < 0.05).

Conclusion:

Huanglian Wendan Decoction can effectively improve the tic symptoms of children with phlegm-heat and wind-driven TS, alleviate the children's TCM symptoms, and reduce the serum DA level, with remarkable clinical efficacy.

Key words

Huanglian Wendan Decoction / Tourette syndrome / Pediatric / Phlegm-heat and wind-driven syndrome / Clinical efficacy

引用本文

张郭莹, 卫妍, 黎彦麟, 凌露, 何磊. 黄连温胆汤化裁治疗小儿多发性抽动症(痰热动风证)的临床研究. 中医药学报, 2026 , 54 (4) : 84 -88 . DOI: 10.19664/j.cnki.1002-2392.260081

Guoying ZHANG, Yan WEI, Yanlin LI, Lu LING, Lei HE. Clinical Study on Modified Huanglian Wendan Decoction in the Treatment of Pediatric Multiple Tic Disorder (Phlegm-Heat Stirring Wind Syndrome)[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (4) : 84 -88 . DOI: 10.19664/j.cnki.1002-2392.260081

基金

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江苏省中医药科技发展计划项目(MS2021059)
南通市卫生健康委员会科研课题(QNZ2023042)

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2026年第54卷第4期

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文章信息

doi: 10.19664/j.cnki.1002-2392.260081

接收时间：2025-01-23
首发时间：2026-09-17
出版时间：2026-04-20

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出版历史

收稿日期：2025-01-23
修回日期：2025-12-16

基金

江苏省中医药科技发展计划项目(MS2021059)

南通市卫生健康委员会科研课题(QNZ2023042)

作者信息

^1.南京中医药大学南通附属医院，江苏南通 226001

^2.南通瑞慈医院，江苏南通 226010

通讯作者:

^* 何磊（1992-），男，主治中医师，研究方向：儿童神经及呼吸道疾病防治。

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https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260081

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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