Article(id=1303760944866292271, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1303760924272259535, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260064, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1735488000000, receivedDateStr=2024-12-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788770431963, onlineDateStr=2026-09-07, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788770431963, onlineIssueDateStr=2026-09-07, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788770431963, creator=13041195026, updateTime=1788770431963, updator=13041195026, issue=Issue{id=1303760924272259535, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='3', pageStart='1', pageEnd='125', issueExtLink='null', onlineDate='null', pubDate='1773936000000', pubDateStr='2026-03-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788770427052, creator='13041195026', updateTime=1788934400812, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304448680157803505, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1303760924272259535, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304448680157803506, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1303760924272259535, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=102, endPage=106, ext={EN=ArticleExt(id=1303760945201836593, articleId=1303760944866292271, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Study on the Therapeutic Efficacy and Immunological Mechanisms of the Jianpi Yishen Huoxue Tongluo Paste Formula in the Stable Phase of Chronic Obstructive Pulmonary Disease, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective: To analyze the therapeutic effect and immune mechanism of the Jianpi Yishen Huoxue Tongluo Paste Formula on the stable stage of chronic obstructive pulmonary disease (COPD).Methods: The clinical data of 83 COPD patients admitted to the outpatient service of Suzhou Integrated Chinese and Western Medicine Hospital during January, 2021 to August, 2023 were retrospectively analyzed. According to the different treatment methods, they were divided into control group (n = 40,Western medicine treatment) and observation group (n = 43,Western medicine +Jianpi Yishen Huoxue Tongluo Paste Formula),which were treated for 2 months. The clinical efficacy, adverse reactions, Chinese medicine symptom scores before and after treatment, dyspnea severity [modified British Medical Research Council Respiratory Questionnaire (mMRC)], symptoms [COPD Self - Assessment Test Questionnaire (CAT)], exercise endurance [6 - minute walking distance (6MWD)], and T helper cell 17(Th17)/regulatory T were compared between the two groups Cell (Treg) ratio, and the annual number of attacks 1 year before treatment and 1 year after treatment.Results: The total effective rate of observation group was 95.00%, which was higher than that of control group 76.32% (P <0.05). After treatment, the syndrome score, mMRC score,CAT score, annual number of attacks and Th17/Treg ratio were decreased in both groups, and the 6MWD value was increased, and the change was greater in the observation group compared with the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the control group(13.16%) and the observation group (5.00%) (P >0.05).Conclusion: The Jianpi Yishen Huoxue Tongluo Paste Formula is safer and more effective in the treatment of stable COPD It may exert its effect by affecting the Th17/Treg balance., authors=DONG Fan¹, GU Xiaoqiong¹, XIE Rixi¹, authorsList=DONG Fan, GU Xiaoqiong, XIE Rixi, authorCompany=1 Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou 215000, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1303760945117950512, articleId=1303760944866292271, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=健脾益肾活血通络膏方对慢性阻塞性肺疾病稳定期治疗效果及免疫机制的研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=目的： 分析健脾益肾活血通络膏方对慢性阻塞性肺疾病（COPD）稳定期的治疗效果及免疫机制。方法： 回顾性分析2021年1月—2023年8月苏州中西医结合医院门诊收治的 83例COPD稳定期患者的临床资料，按照治疗方法的不同分为对照组（40例，西药治疗）和观察组（43例，西药+健脾益肾活血通络膏方治疗），均连续治疗2个月。比较两组的临床疗效、不良反应及治疗前后的中医证候积分、呼吸困难严重程度［改良版英国医学研究委员会呼吸问卷（mMRC）］、症状［慢阻肺自我评估测试问卷（CAT）］、运动耐力［6 min步行距离（6 MWD）］、T辅助细胞17（Th17）/调节性T细胞（Treg）比值，并统计治疗前1年、治疗后1年的COPD年发作次数。结果： 观察组总有效率为95.00% （38/40），高于对照组的76.32% （29/38），差异有统计学意义（P < 0.05）。治疗后，两组中医证候积分、mMRC评分、CAT评分、年发作次数及Th17/Treg比值均降低（P < 0.05，P < 0.01），6 MWD值升高（P < 0.05），且与对照组相比，观察组变化更明显（P < 0.05，P < 0.01）。在不良反应发生率方面，对照组（13.16%）与观察组（5.00%）比较，差异无统计学意义（P > 0.05）。结论： 健脾益肾活血通络膏方治疗COPD稳定期更为安全有效，其可能是通过影响Th17/Treg平衡而发挥作用。, authors=董凡¹, 顾小琼¹, 谢日禧¹, authorsList=董凡, 顾小琼, 谢日禧, authorCompany=1. 苏州市中西医结合医院，江苏 苏州 215000, correspAuthors=* 谢日禧（1982-），男，副主任医师，从事呼吸内科相关研究。, authorNote=董凡（1995-），女，硕士，主治医师，从事中医内科相关研究。, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=f5gaOSlpfpkazAeGW/mMbA==, pdfFileSize=1187929, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=江苏省中医药科技发展计划项目 (MS2021013))}, authors=null, keywords=[Keyword(id=1304742898549936435, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1303760944866292271, language=CN, orderNo=1, keyword=健脾益肾活血通络膏方), Keyword(id=1304742898621239604, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1303760944866292271, language=CN, orderNo=2, keyword=慢性阻塞性肺疾病), Keyword(id=1304742898692542773, tenantId=1146029695717560320, 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