Article(id=1303760927967441373, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1303760924272259535, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260051, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1741881600000, receivedDateStr=2025-03-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788770427933, onlineDateStr=2026-09-07, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788770427933, onlineIssueDateStr=2026-09-07, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788770427933, creator=13041195026, updateTime=1788770427933, updator=13041195026, issue=Issue{id=1303760924272259535, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='3', pageStart='1', pageEnd='125', issueExtLink='null', onlineDate='null', pubDate='1773936000000', pubDateStr='2026-03-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788770427052, creator='13041195026', updateTime=1788934400812, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304448680157803505, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1303760924272259535, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304448680157803506, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1303760924272259535, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=34, endPage=38, ext={EN=ArticleExt(id=1303760928290402784, articleId=1303760927967441373, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Comparison of Anti - inflammatory Effects of Perilla Folium with Different Leaf Colors and Its Correlation Analysis with Leaf Color Values and Chemical Compositions, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective: To study the anti - inflammatory effect of Perilla Folium with both surfaces purple (PP), Perilla Folium with upper surface green and the lower surface purple (GP), Perilla Folium with both surfaces green (GG) and to analyze the relationship between the anti - inflammatory effect, leaf color chromatic values (L, a*, b*, E* ab, R - value, G - value, and B - value), and the contents of perilla aldehydes, rosmarinic acid, and anthocyanins.Methods: The CCK - 8 method was used to determine the effects of three types of Perilla Folium on RAW 264.7 monocyte - macrophage survival rates, and partial least squares discriminant analysis (PLS - DA) was used to explore the differences between perilla leaves with different leaf colors. Pearson correlation coefficients were used to systematically analyze the correlation between the seven leaf color values, including Red image component mean value(R - value), Green image component mean value (G - value), Blue image component mean value (B - value), Red green value (a*), Yellow blue value (b*), Brightness value (L*), and Total color value (E* ab), as well as the contents of perilla aldehyde, anthocyanin, and rosmarinic acid, and the anti - inflammatory effect in order to reveal the intrinsic links between anti - inflammatory effects and colorimetric characteristics and chemical composition.Results: PP, GP, and GG all showed certain anti - inflammatory effects. At a concentration of 25 mg/mL, the survival rates of PP, GP, and GG ranged from 56% to 94%, 49% to 123%, and 64% to 110%, respectively. One - way ANOVA showed that there was no significant difference among the three. The results of PLS - DA showed that Perilla Folium with different leaf colors were each grouped into one category, and seven key differential indexes, including perilla aldehyde, anthocyanins, R value, b*, E* ab, rosemarinic acid and L*, were screened out. Correlation analysis showed that cell survival rates were positively correlated with b* - value.Conclusion: The anti - inflammatory effects of Perilla Folium did not significantly differ among the three leaf colors, and higher b* - value was associated with stronger anti - inflammatory effects., authors=LIU Wenli1 , KANG Shuai2 , LI Lingxi1 , NIE Lixing2 , WEI Feng2 , authorsList=LIU Wenli, KANG Shuai, LI Lingxi, NIE Lixing, WEI Feng, authorCompany=1 Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 117004, China; 目的： 研究双紫紫苏叶（PP）、面绿背紫紫苏叶（GP）、双绿紫苏叶（GG）的抗炎作用，并分析抗炎作用与叶色色数值（L*、a*、b*、E*ab、R值、G值、B值）、紫苏醛、迷迭香酸、花青素的含量之间的关系。方法： 采用CCK - 8法测定3种紫苏叶对RAW 264.7单核巨噬细胞存活率的影响，结合偏最小二乘判别分析法（PLS - DA）探讨不同叶色紫苏叶的差异。利用Pearson相关系数对红色像元分量均值（R值）、绿色像元分量均值（G值）、蓝色像元分量均值（B值）、红绿色值（a*值）、黄蓝色值（b*值）、亮度值（L*值）、总色值（E* ab值）等 7种叶色色数值、紫苏醛、花青素和迷迭香酸的含量及抗炎作用之间的关联性进行系统性分析，以揭示抗炎作用与色度特征及化学成分之间的内在联系。结果： PP、GP、GG均具有一定的抗炎作用，在25 mg/mL浓度下，PP的存活率在56% ~ 94%，GP的存活率在49% ~123%，GG的存活率在64% ~ 110%。单因素方差分析表明，PP、GP、GG的抗炎作用无明显差异（P >0.05）。PLS - DA结果显示，不同叶色紫苏叶各自归为一类，并筛选出紫苏醛、花青素、R值、b*值、E*ab值、迷迭香酸和L*值等7个关键差异性成分。相关性分析显示，细胞存活率与b*值呈正相关。结论： 三种叶色紫苏叶的抗炎作用无明显区别，紫苏叶叶色的b*值越高，其抗炎作用越强。, authors=刘雯丽1 , 康帅2 , 李灵犀1 , 聂黎行2 , 魏锋2 , authorsList=刘雯丽, 康帅, 李灵犀, 聂黎行, 魏锋, authorCompany=1. 沈阳药科大学功能食品与葡萄酒学院，辽宁 沈阳 117004;
中医药学报
|中药研究
2026
, 54
(3) :
34
-38
不同叶色紫苏叶抗炎作用比较及其与叶色值和化学成分的相关性分析
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刘雯丽1 , 康帅2 , 李灵犀1 , 聂黎行2 , 魏锋2
作者信息
1. 沈阳药科大学功能食品与葡萄酒学院，辽宁 沈阳 117004;
通讯作者:
* 李灵犀（1988-），女，博士，副教授，硕士生导师，研究方向：药物分析。聂黎行（1982-），女，博士，研究员，硕士生导师，研究方向：中药质量评价及质谱成像技术。
作者简介:
刘雯丽（1998-），女，硕士研究生，研究方向：中药质量与评价。
Comparison of Anti - inflammatory Effects of Perilla Folium with Different Leaf Colors and Its Correlation Analysis with Leaf Color Values and Chemical Compositions
LIU Wenli1 , KANG Shuai2 , LI Lingxi1 , NIE Lixing2 , WEI Feng2
Affiliations
1 Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 117004, China;
doi: 10.19664/j.cnki.1002-2392.260051
文章导航
目的： 研究双紫紫苏叶（PP）、面绿背紫紫苏叶（GP）、双绿紫苏叶（GG）的抗炎作用，并分析抗炎作用与叶色色数值（L*、a*、b*、E*ab、R值、G值、B值）、紫苏醛、迷迭香酸、花青素的含量之间的关系。方法： 采用CCK - 8法测定3种紫苏叶对RAW 264.7单核巨噬细胞存活率的影响，结合偏最小二乘判别分析法（PLS - DA）探讨不同叶色紫苏叶的差异。利用Pearson相关系数对红色像元分量均值（R值）、绿色像元分量均值（G值）、蓝色像元分量均值（B值）、红绿色值（a*值）、黄蓝色值（b*值）、亮度值（L*值）、总色值（E* ab值）等 7种叶色色数值、紫苏醛、花青素和迷迭香酸的含量及抗炎作用之间的关联性进行系统性分析，以揭示抗炎作用与色度特征及化学成分之间的内在联系。结果： PP、GP、GG均具有一定的抗炎作用，在25 mg/mL浓度下，PP的存活率在56% ~ 94%，GP的存活率在49% ~123%，GG的存活率在64% ~ 110%。单因素方差分析表明，PP、GP、GG的抗炎作用无明显差异（P >0.05）。PLS - DA结果显示，不同叶色紫苏叶各自归为一类，并筛选出紫苏醛、花青素、R值、b*值、E*ab值、迷迭香酸和L*值等7个关键差异性成分。相关性分析显示，细胞存活率与b*值呈正相关。结论： 三种叶色紫苏叶的抗炎作用无明显区别，紫苏叶叶色的b*值越高，其抗炎作用越强。
紫苏叶
/
抗炎作用
/
色数值
/
化学成分
/
相关性
Objective: To study the anti - inflammatory effect of Perilla Folium with both surfaces purple (PP), Perilla Folium with upper surface green and the lower surface purple (GP), Perilla Folium with both surfaces green (GG) and to analyze the relationship between the anti - inflammatory effect, leaf color chromatic values (L, a*, b*, E* ab, R - value, G - value, and B - value), and the contents of perilla aldehydes, rosmarinic acid, and anthocyanins.Methods: The CCK - 8 method was used to determine the effects of three types of Perilla Folium on RAW 264.7 monocyte - macrophage survival rates, and partial least squares discriminant analysis (PLS - DA) was used to explore the differences between perilla leaves with different leaf colors. Pearson correlation coefficients were used to systematically analyze the correlation between the seven leaf color values, including Red image component mean value(R - value), Green image component mean value (G - value), Blue image component mean value (B - value), Red green value (a*), Yellow blue value (b*), Brightness value (L*), and Total color value (E* ab), as well as the contents of perilla aldehyde, anthocyanin, and rosmarinic acid, and the anti - inflammatory effect in order to reveal the intrinsic links between anti - inflammatory effects and colorimetric characteristics and chemical composition.Results: PP, GP, and GG all showed certain anti - inflammatory effects. At a concentration of 25 mg/mL, the survival rates of PP, GP, and GG ranged from 56% to 94%, 49% to 123%, and 64% to 110%, respectively. One - way ANOVA showed that there was no significant difference among the three. The results of PLS - DA showed that Perilla Folium with different leaf colors were each grouped into one category, and seven key differential indexes, including perilla aldehyde, anthocyanins, R value, b*, E* ab, rosemarinic acid and L*, were screened out. Correlation analysis showed that cell survival rates were positively correlated with b* - value.Conclusion: The anti - inflammatory effects of Perilla Folium did not significantly differ among the three leaf colors, and higher b* - value was associated with stronger anti - inflammatory effects.
Perilla Folium
/
Anti - inflammatory effect
/
Color values
/
Chemical composition
/
Correlation
刘雯丽, 康帅, 李灵犀, 聂黎行, 魏锋.
不同叶色紫苏叶抗炎作用比较及其与叶色值和化学成分的相关性分析.
中医药学报,
2026
, 54
(3)
: 34
-38
.
DOI: 10.19664/j.cnki.1002-2392.260051
LIU Wenli, KANG Shuai, LI Lingxi, NIE Lixing, WEI Feng.
Comparison of Anti - inflammatory Effects of Perilla Folium with Different Leaf Colors and Its Correlation Analysis with Leaf Color Values and Chemical Compositions[J].
Acta Chinese Medicine and Pharmacology ,
2026
, 54
(3)
: 34
-38
.
DOI: 10.19664/j.cnki.1002-2392.260051
2026年第54卷第3期
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doi: 10.19664/j.cnki.1002-2392.260051
接收时间：2025-03-14
首发时间：2026-09-07
https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260051
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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