Article(id=1304438819630113339, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260037, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1736438400000, receivedDateStr=2025-01-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788932049900, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788932049900, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788932049900, creator=13701087609, updateTime=1788932049900, updator=13701087609, issue=Issue{id=1304438800676048898, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='2', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1771516800000', pubDateStr='2026-02-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788932045382, creator='13701087609', updateTime=1788934764784, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304450206712483920, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304450206712483921, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=73, endPage=77, ext={EN=ArticleExt(id=1304438819936297533, articleId=1304438819630113339, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Clinical Efficacy Study of Jianpi Shuyi Decoction in Treating Patients with Chronic Pancreatitis of Liver Depression and Spleen Deficiency Syndrome, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective: To observe the clinical efficacy of oral Jianpi Shuyi Decoction in treating patients with chronic pancreatitis (CP) of liver depression and spleen deficiency syndrome.Methods: Using a randomized number table method, from September 2019 to July 2023 80 CP patients with liver depression and spleen deficiency syndrome who visited Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were divided into a control group and an experimental group, with 40 cases in each group. The control group received Western medicine treatment, while the experimental group received the same plus Jianpi Shuyi Decoction. The treatment course was 4 weeks, and both groups were treated for 2 courses. The clinical efficacy, traditional Chinese medicine (TCM) symptom scores, abdominal pain visual analog scale (VAS) scores, laboratory indicators [serum amylase (AMS), lipase (LPS), fasting blood glucose (FBG)] levels, and the diameters of the main pancreatic duct and common bile duct were compared between the two groups.Results: After treatment, the total clinical effective rate in the experimental group was significantly higher than that in the control group (89.74% vs. 68.42%), with a statistically significant difference(P < 0.05). After treatment, abdominal pain, poor appetite, and pain - diarrhea symptoms in the control group were significantly reduced compared with those before treatment (P < 0.05). In the experimental group, abdominal pain, abdominal distension, poor appetite, depression and irritability, loose and sticky stools, and pain - diarrhea symptoms were significantly reduced compared with those before treatment (P < 0.05). Moreover, the scores for abdominal pain, abdominal distension, loose and sticky stools, and pain - diarrhea symptoms in the experimental group were significantly lower than those in the control group (P < 0.05). After treatment, the VAS scores of both groups were significantly reduced (P < 0.05), and the VAS score of the experimental group was significantly lower than that of the control group(P < 0.05). The AMS levels of both groups were significantly reduced (P < 0.05), and the experimental group was significantly lower than the control group (P < 0.05). No significant reduction in LPS level was observed in the control group (P > 0.05), while the LPS level in the experimental group was significantly reduced (P < 0.05) and significantly lower than that in the control group (P < 0.05). No significant reduction in FBG levels was observed in either group(P > 0.05), and there was no statistically significant difference between the two groups (P > 0.05). After treatment, the diameters of the main pancreatic duct and common bile duct in both groups showed no significant changes compared with those before treatment (P > 0.05).Conclusion: Jianpi Shuyi Decoction can effectively alleviate clinical symptoms such as abdominal pain, improve digestive function, reduce serum amylase and lipase levels, alleviate inflammatory responses, and demonstrate good safety in treating CP patients with liver depression and spleen deficiency syndrome., authors=CHEN Meng¹, GAN Kexin¹, WU Jingyi¹, LI Tao¹, LING Jianghong¹, GONG Biao¹, CAI Gan¹, XUE Hui¹, LI Fu¹, authorsList=CHEN Meng, GAN Kexin, WU Jingyi, LI Tao, LING Jianghong, GONG Biao, CAI Gan, XUE Hui, LI Fu, authorCompany=1 Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目 (81904017); 国家中医优势专科建设项目 (4585); 2024年度上海中医药大学科技发展项目 (自然科学类24KFL064); 上海中医药大学附属曙光医院名医导师团项目), CN=ArticleExt(id=1304438819852411452, articleId=1304438819630113339, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=健脾舒胰汤对慢性胰腺炎肝郁脾虚证患者的临床疗效研究, columnId=1303760933084484510, journalTitle=中医药学报, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=目的： 观察口服健脾舒胰汤治疗肝郁脾虚证慢性胰腺炎（CP）患者的临床疗效。 方法： 采用随机数字表法，将2019年9月—2023年7月在上海中医药大学附属曙光医院就诊的80例肝郁脾虚证CP患者划分为对照组和试验组，每组40例。对照组接受相同的标准治疗，而试验组则在此基础上服用健脾舒胰汤，4周为1个疗程，共治疗2个疗程。比较两组临床疗效、中医症状评分、腹痛视觉模拟量表（VAS）评分、实验室指标［血清淀粉酶（AMS）、脂肪酶（LPS）、血糖（FBG）］水平、主胰管及胆总管直径。 结果： 治疗后试验组临床总有效率显著高于对照组（89.74% vs 68.42%），差异有统计学意义（P <0.05）。治疗后，对照组腹痛、食少纳呆、痛泻症状较治疗前明显下降（P < 0.05）；试验组腹痛、腹胀、食少纳呆、抑郁烦躁、便溏不爽、痛泻症状较治疗前明显下降（P < 0.05）；且试验组腹痛、腹胀、便溏不爽、痛泻症状评分明显低于对照组（P < 0.05）。治疗后两组VAS评分均明显降低（P < 0.05），且试验组VAS评分显著低于对照组（P < 0.05）。两组AMS水平均明显降低（P < 0.05），且试验组显著低于对照组（P < 0.05）。对照组LPS水平未见明显降低（P > 0.05），试验组LPS水平显著降低（P < 0.05），且试验组显著低于对照组（P < 0.05）。两组FBG水平均未见明显降低（P > 0.05），且两组比较差异无统计学意义（P > 0.05）。治疗后，两组患者主胰管、胆总管直径与治疗前比较变化不明显（P > 0.05）。 结论： 健脾舒胰汤治疗肝郁脾虚证CP患者可有效减轻腹痛等临床症状，改善消化功能，降低血清淀粉酶、脂肪酶指标，减轻炎症反应，安全性较好。, authors=陈萌¹, 甘可欣¹, 吴静怡¹, 李涛¹, 凌江红¹, 龚彪¹, 蔡淦¹, 薛慧¹, 李甫¹, authorsList=陈萌, 甘可欣, 吴静怡, 李涛, 凌江红, 龚彪, 蔡淦, 薛慧, 李甫, authorCompany=1 上海中医药大学附属曙光医院，上海 201203, correspAuthors=* 薛慧（1977-），女，副主任医师，从事中西医结合治疗疼痛相关疾病的临床与基础研究。李甫（1985-），男，硕士，副主任医师，从事中西医结合治疗胆胰相关疾病的临床与基础研究。, authorNote=陈萌（1990-），男，博士，主治医师，从事中医药治疗消化系统疾病及中医经典方药的临床与基础研究。, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=TGhMpPO90Qrok9BhAz4tfQ==, pdfFileSize=1229958, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, 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