Article(id=1304438810729800201, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260028, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1727193600000, receivedDateStr=2024-09-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788932047779, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788932047779, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788932047779, creator=13701087609, updateTime=1788932047779, updator=13701087609, issue=Issue{id=1304438800676048898, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='2', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1771516800000', pubDateStr='2026-02-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788932045382, creator='13701087609', updateTime=1788934764784, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304450206712483920, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304450206712483921, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=28, endPage=33, ext={EN=ArticleExt(id=1304438811052761611, articleId=1304438810729800201, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Properties and Morphology of Coptis Chinensis - Evodia Rutaecarpa Self - Assemblies and Their Effects on Seven Components, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective: To investigate the properties and morphology of Coptis chinensis - Evodia rutaecarpa self- assemblies and their effects on the contents of seven components: epiberberine hydrochloride, coptisine hydrochloride, palmatine hydrochloride, berberine hydrochloride, evodiamine, rutaecarpine, and evodin.Methods: The morphology, fluidity, and water absorption rate of the self - assemblies were characterized. High - performance liquid chromatography(HPLC) was used to compare the differences in the seven components among single decoctions of Coptis chinensis and Evodia rutaecarpa, co - decoction supernatant, and the self - assemblies.Results: The self - assemblies exhibited good fluidity and water - absorbing swelling properties. Scanning electron microscopy revealed that they were spherical particle aggregates. The formation of self - assemblies led to a decrease in the contents of the seven components in the supernatant, with significant reductions in evodiamine, berberine hydrochloride, and evodin, while epiberberine hydrochloride slightly increased. Among the seven components in the self - assemblies, berberine hydrochloride was relatively abundant and likely a key component in the formation of the self - assemblies.Conclusion: A quantitative method for the seven components in Coptis chinensis - Evodia rutaecarpa self - assemblies was established, which can be used by enterprises to monitor changes in the main components in the self - assemblies and supernatant. The Coptis chinensis - Evodia rutaecarpa self - assemblies are fundamentally different from chemical precipitation and can serve as a green strategy for supramolecular design and construction. This provides insights into the reuse of carrier - free self- assembled drugs and offers a new perspective for understanding self - assembly phenomena in traditional Chinese medicine decoctions., authors=LI Qinghong¹, HUI Jiana¹, HU Yaojiang¹, NIE Junyao¹, HU Qingjin¹, ZHANG Wenping¹, authorsList=LI Qinghong, HUI Jiana, HU Yaojiang, NIE Junyao, HU Qingjin, ZHANG Wenping, authorCompany=1 School of Chinese Materia Medica, Yunnan University of Chinese Medicine & Yunnan Provincial Key Laboratory of Southern Medicine Sustainable Utilization, Kunming 650500, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=云南省科学技术厅中医联合专项-面上项目 (202101AG070057)), CN=ArticleExt(id=1304438810973069834, articleId=1304438810729800201, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=黄连-吴茱萸自组装体性质形态及其形成对7种成分的影响, columnId=1303760928135213534, journalTitle=中医药学报, columnName=中药研究, runingTitle=null, highlight=null, articleAbstract=目的： 探究黄连-吴茱萸自组装体的性质形态及其形成对盐酸表小檗碱、盐酸黄连碱、盐酸巴马汀、盐酸小檗碱、吴茱萸内酯、吴茱萸碱、吴茱萸次碱7种成分含量的影响。 方法： 对自组装体的形态、流动性和吸水率进行表征，并通过高效液相色谱法（HPLC）对比黄连和吴茱萸单煎液、共煎上清液及自组装体中的7种成分的差异。 结果： 自组装体具有良好的流动性和吸水膨胀性，扫描电镜观察显示其为类球形颗粒聚集体。自组装体的形成导致上清液中7种成分含量降低，吴茱萸碱、盐酸小檗碱、吴茱萸内酯含量下降明显，盐酸表小檗碱则有所提升，在自组装体7种成分中以盐酸小檗碱含量相对较高，且极可能为自组装体形成的关键成分。 结论： 建立了黄连-吴茱萸自组装体中7种成分的定量方法，可用于监测黄连-吴茱萸自组装体和上清液中主要成分含量变化情况，黄连-吴茱萸自组装体与化学沉淀有着本质上的不同，可作为超分子设计和构建的绿色策略，为无载体的自组装药物的再利用提供了思路，为理解中药汤剂中自组装现象提供新的视角。, authors=李晴红¹, 灰加娜¹, 胡耀江¹, 聂军谣¹, 胡清紧¹, 张文平¹, authorsList=李晴红, 灰加娜, 胡耀江, 聂军谣, 胡清紧, 张文平, authorCompany=1 云南中医药大学中药学院 云南省南药可持续利用研究重点实验室，云南 昆明 650500, correspAuthors=* 张文平（1981-），女，博士，副教授，研究方向：中药活性物质研究与产品开发、社会管理与药学、药事管理学。, authorNote=李晴红（1999-），女，硕士研究生，主要从事中药活性物质研究与产品开发。, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=9cTDsMKWl3fOca/M0zS+Qg==, pdfFileSize=4512886, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, keywords=[Keyword(id=1304438811220533772, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1304438810729800201, language=CN, orderNo=1, keyword=黄连-吴茱萸药对), Keyword(id=1304438811308614157, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1304438810729800201, language=CN, orderNo=2, keyword=自组装体), Keyword(id=1304438811375723022, tenantId=1146029695717560320, journalId=1302318977290174537, 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