Article(id=1304438806875238529, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260027, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1719417600000, receivedDateStr=2024-06-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788932046859, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788932046859, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788932046859, creator=13701087609, updateTime=1788932046859, updator=13701087609, issue=Issue{id=1304438800676048898, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='2', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1771516800000', pubDateStr='2026-02-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788932045382, creator='13701087609', updateTime=1788934764784, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304450206712483920, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304450206712483921, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=22, endPage=27, ext={EN=ArticleExt(id=1304438808846561411, articleId=1304438806875238529, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Intervention Effect of Feijin Mixture on Airway Mucus Hypersecretion in Mice with Cough Variant Asthma, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective: To investigate the intervention effect of Feijin Mixture on airway mucus hypersecretion in mice with cough variant asthma (CVA).Methods: Mice were divided into five groups: control group, model group, low- dose Feijin Mixture group, high - dose Feijin Mixture group, and prednisone group. A CVA mouse model was established by sensitization and challenge with ovalbumin (OVA) and aluminum hydroxide [Al(OH)₃]. Mice in the control and model groups were administered normal saline by gavage, while mice in the treatment groups received corresponding doses of drugs. Pathological changes in lung tissue were detected by hematoxylin - eosin (HE) staining. Mucin content secreted by tracheal epithelial cells was observed by Alcian blue - periodic acid - Schiff (AB - PAS)staining. Mucin 5AC (Mucin5AC) content in lung tissue was detected by immunohistochemistry. Tumor necrosis factor - α (TNF - α) levels in lung tissue and bronchoalveolar lavage fluid, as well as serum levels of interleukin - 4(IL - 4) and interleukin-8 (IL - 8), were measured by enzyme - linked immunosorbent assay (ELISA). Epidermal growth factor receptor (EGFR) expression in lung tissue was detected by Western blot.Results: Compared with the model group, the Feijin Mixture groups showed reduced bronchial epithelial goblet cell hyperplasia, inflammatory cell infiltration around the respiratory tract and bronchi and blood vessels, and reduced fibroblast hyperplasia in alveolar walls of the respiratory region. The number of goblet cells, Mucin5AC content, PAS - positive staining area, TNF - α, IL - 4, IL - 8, and p - EGFR/EGFR expression in lung tissue were decreased in the Feijin Mixture groups (P <0.05).Conclusion: Feijin Mixture can reduce the expression of airway mucin - like proteins, alleviate pathological changes and inflammatory responses, thereby effectively intervening in airway mucus hypersecretion through the TNF - α/EGFR pathway., authors=CAO Weihong¹, WANG Shaozheng¹, PAN Sijing¹, CHEN Xue¹, authorsList=CAO Weihong, WANG Shaozheng, PAN Sijing, CHEN Xue, authorCompany=1 Ningxia Hui Autonomous Region Hospital of Traditional Chinese Medicine and Chinese Medicine Research Institute, Yinchuan 750021, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=宁夏自然科学基金项目 (2022AAC03403)), CN=ArticleExt(id=1304438807135285378, articleId=1304438806875238529, tenantId=1146029695717560320, journalId=1302318977290174537, language=CN, title=肺金合剂对咳嗽变异性哮喘小鼠气道黏液高分泌的干预作用研究, columnId=1303760926633652690, journalTitle=中医药学报, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=目的： 探究肺金合剂对咳嗽变异性哮喘（CVA）小鼠气道黏液高分泌的干预作用。 方法： 将小鼠分为对照组、模型组、肺金合剂低剂量组、肺金合剂高剂量组、泼尼松组共5组，采用卵蛋白（OVA）和氢氧化铝［Al（OH）₃］联合激发致敏建立CVA小鼠模型，对照组和模型组小鼠灌胃生理盐水，给药组小鼠给予相应剂量的药物治疗。采用苏木精-伊红（HE）染色检测肺脏组织病理改变；阿利新蓝-过碘酸-雪夫（AB - PAS）染色观察气管上皮细胞分泌的黏蛋白含量；免疫组化检测肺组织中黏蛋白5AC（Mucin5AC）的含量；酶联免疫吸附测定法（ELISA）检测小鼠肺脏和肺泡灌洗液中肿瘤坏死因子- α（TNF - α）以及血清中白细胞介素- 4（IL - 4）和白细胞介素- 8（IL - 8）的含量；蛋白免疫印迹法（Western Blot）检测小鼠肺脏组织中表皮生长因子受体（EGFR）的表达。 结果： 与模型组相比，肺金合剂各剂量组治疗后小鼠支气管上皮杯状细胞增生、呼吸部和支气管及血管周围炎性细胞浸润及呼吸部肺泡壁纤维细胞增生减少，小鼠肺组织中杯状细胞数、Mucin5AC含量、PAS染色阳性表达面积、TNF - α、IL - 4、IL - 8和p - EGFR/EGFR表达降低（P < 0.05，P < 0.01）。 结论： 肺金合剂能够通过TNF- α/EG- FR途径，减少气道黏液样蛋白的表达，减轻组织病理改变以及炎症反应，从而对气道黏液高分泌起到较好的干预作用。, authors=曹维宏¹, 王绍政¹, 潘思静¹, 陈雪¹, authorsList=曹维宏, 王绍政, 潘思静, 陈雪, authorCompany=1 宁夏回族自治区中医医院暨中医研究院，宁夏 银川 750021, correspAuthors=null, authorNote=曹维宏（1970-），男，硕士，主任医师，从事呼吸系统疾病和睡眠疾病相关研究。, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=e5KKEH/UfoGHbqNcYb5oHA==, pdfFileSize=6068595, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, keywords=[Keyword(id=1304438809224048772, tenantId=1146029695717560320, journalId=1302318977290174537, articleId=1304438806875238529, language=CN, orderNo=1, keyword=肺金合剂), Keyword(id=1304438809299546245, tenantId=1146029695717560320, 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