Article(id=1304438809928683566, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, articleNumber=null, orderNo=null, doi=10.19664/j.cnki.1002-2392.260026, pmid=null, cstr=null, oa=null, hot=0, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1715184000000, receivedDateStr=2024-05-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1788932047588, onlineDateStr=2026-09-09, pubDate=null, pubDateStr=null, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1788932047588, onlineIssueDateStr=2026-09-09, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1788932047588, creator=13701087609, updateTime=1788932047588, updator=13701087609, issue=Issue{id=1304438800676048898, tenantId=1146029695717560320, journalId=1302318977290174537, year='2026', volume='54', issue='2', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1771516800000', pubDateStr='2026-02-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1788932045382, creator='13701087609', updateTime=1788934764784, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1304450206712483920, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1304450206712483921, tenantId=1146029695717560320, journalId=1302318977290174537, issueId=1304438800676048898, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=15, endPage=21, ext={EN=ArticleExt(id=1304438810230673456, articleId=1304438809928683566, tenantId=1146029695717560320, journalId=1302318977290174537, language=EN, title=Effects of Yinhuang Lotion on IL - 18, TNF - α, and the HIF - 1α/VEGF Pathway in Diabetic Ulcer Rats, columnId=null, journalTitle=Acta Chinese Medicine and Pharmacology, columnName=null, runingTitle=null, highlight=null, articleAbstract=Objective: To investigate the therapeutic effects and mechanisms of Yinhuang Lotion on wound healing in diabetic ulcer rats.Methods: A diabetic model was established in SD rats using a high - sugar, high - fat diet combined with a single intraperitoneal injection of streptozotocin (STZ). A diabetic skin ulcer model was then created through surgical intervention and stimulation with 50% glacial acetic acid. The successfully modeled rats were randomly divided into a model group, a Yinhuang Lotion group, and a Kangfuxin Liquid group, with 12 rats in each group. An additional 12 normal SD rats served as the control group. The ulcer wounds of the control and model groups were covered with gauze soaked in normal saline. The Yinhuang Lotion group received gauze soaked in Yinhuang Lotion, while the Kangfuxin Liquid group was treated with gauze soaked in Kangfuxin Liquid. All groups underwent daily dressing changes for 28 days. On days 14 and 28, six rats from each group were randomly selected to assess general condition, body weight, fasting blood glucose, ulcer area, and ulcer healing rate. Serum levels of interleukin - 18 (IL - 18) and tumor necrosis factor - α (TNF - α) were measured using ELISA, while the expression levels of hypoxia - inducible factor 1α (HIF - 1α) and vascular endothelial growth factor (VEGF) were detected via Western blot.Results: On days 14 and 28, compared with the control group, the model group exhibited larger ulcer areas, lower ulcer healing rates, higher levels of inflammatory factors, and reduced expression of related proteins (P <0.05). In contrast, the Yinhuang Lotion and Kangfuxin Liquid groups showed smaller ulcer areas, higher ulcer healing rates, lower inflammatory factor levels, and increased expression of related proteins (P <0.05). Furthermore, on days 14 and 28, the Yinhuang Lotion group demonstrated significantly smaller ulcer areas (P <0.01), higher ulcer healing rates (P < 0.01), lower inflammatory factor levels (P <0.01), and higher expression of related proteins (P < 0.01) compared with the Kangfuxin Liquid group.Conclusion: Yinhuang Lotion can promote angiogenesis in ischemic wounds, accelerate tissue repair, and shorten the treatment period for diabetic ulcers by inhibiting inflammatory factors and regulating the HIF - 1α/VEGF signaling pathway, thereby effectively treating diabetic ulcer wounds., authors=WANG Peiyu1 , JIA Zhen2 , GAO Jie2 , LIANG Xuewei2 , authorsList=WANG Peiyu, JIA Zhen, GAO Jie, LIANG Xuewei, authorCompany=1 Heilongjiang University of Chinese Medicine, Harbin 150040, China; 目的： 探讨银黄洗剂对糖尿病溃疡大鼠创面的治疗效果及机制。 方法： 采用高糖高脂饮食+一次性腹腔注射链脲佐菌素（STZ）建立SD大鼠糖尿病模型；手术+50%冰醋酸刺激建立糖尿病大鼠皮肤溃疡模型；将成模大鼠随机分为模型组、银黄洗剂组和康复新液组，每组12只，正常SD大鼠12只作为对照组。对照组和模型组大鼠溃疡面用浸生理盐水的纱布块敷盖；银黄洗剂组大鼠溃疡面用浸银黄洗剂药液的纱布块敷盖；康复新液组大鼠溃疡面用浸康复新液的纱布块敷盖。各组每日换药1次，连续给药28 d。在给药14 d、28 d时，各组随机选取6只大鼠，观察大鼠一般状态、体质量、空腹血糖、溃疡面积和溃疡愈合率，ELISA法检测大鼠血清白细胞介素- 18（IL - 18）、肿瘤坏死因子- α（TNF - α）含量，Western blot法检测缺氧诱导因子1α（HIF - 1α）、血管内皮生长因子（VEGF）表达水平。 结果： 第14、28天时，与对照组比较，模型组大鼠溃疡面积更大，溃疡愈合率低，炎症因子水平高，相关蛋白表达量降低（P <0.05）；第14、28天时，与模型组相比，银黄洗剂组和康复新液组大鼠溃疡面积更小，溃疡愈合率高，炎症因子水平低，相关蛋白表达量高（P < 0.05）；第14、28天时，银黄洗剂组大鼠溃疡面积小于康复新液组（P < 0.01），溃疡愈合率大于康复新液组（P < 0.01），炎症因子水平低于康复新液组（P < 0.01），相关蛋白表达量高于康复新液组（P < 0.01）。 结论： 银黄洗剂可通过抑制炎症因子及调节HIF - 1α/VEGF信号通路，促进缺血创面血管生成，加速创面组织愈合，缩短糖尿病溃疡治疗周期，起到治疗糖尿病溃疡创面的作用。, authors=王培宇1 , 贾振2 , 高杰2 , 梁学威2 , authorsList=王培宇, 贾振, 高杰, 梁学威, authorCompany=1 黑龙江中医药大学，黑龙江 哈尔滨 150040;
中医药学报
|实验研究
2026
, 54
(2) :
15
-21
银黄洗剂对糖尿病溃疡大鼠IL - 18、TNF - α及HIF - 1α/VEGF通路的影响
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王培宇1 , 贾振2 , 高杰2 , 梁学威2
作者信息
1 黑龙江中医药大学，黑龙江 哈尔滨 150040;
通讯作者:
* 梁学威（1988-），女，博士，主治医师，研究方向：中西医结合治疗周围血管系统疾病及其并发症。
作者简介:
王培宇（1991-），男，博士研究生，主治医师，研究方向：中西医结合治疗周围血管疾病的研究。
Effects of Yinhuang Lotion on IL - 18, TNF - α, and the HIF - 1α/VEGF Pathway in Diabetic Ulcer Rats
WANG Peiyu1 , JIA Zhen2 , GAO Jie2 , LIANG Xuewei2
Affiliations
1 Heilongjiang University of Chinese Medicine, Harbin 150040, China;
doi: 10.19664/j.cnki.1002-2392.260026
文章导航
目的： 探讨银黄洗剂对糖尿病溃疡大鼠创面的治疗效果及机制。 方法： 采用高糖高脂饮食+一次性腹腔注射链脲佐菌素（STZ）建立SD大鼠糖尿病模型；手术+50%冰醋酸刺激建立糖尿病大鼠皮肤溃疡模型；将成模大鼠随机分为模型组、银黄洗剂组和康复新液组，每组12只，正常SD大鼠12只作为对照组。对照组和模型组大鼠溃疡面用浸生理盐水的纱布块敷盖；银黄洗剂组大鼠溃疡面用浸银黄洗剂药液的纱布块敷盖；康复新液组大鼠溃疡面用浸康复新液的纱布块敷盖。各组每日换药1次，连续给药28 d。在给药14 d、28 d时，各组随机选取6只大鼠，观察大鼠一般状态、体质量、空腹血糖、溃疡面积和溃疡愈合率，ELISA法检测大鼠血清白细胞介素- 18（IL - 18）、肿瘤坏死因子- α（TNF - α）含量，Western blot法检测缺氧诱导因子1α（HIF - 1α）、血管内皮生长因子（VEGF）表达水平。 结果： 第14、28天时，与对照组比较，模型组大鼠溃疡面积更大，溃疡愈合率低，炎症因子水平高，相关蛋白表达量降低（P <0.05）；第14、28天时，与模型组相比，银黄洗剂组和康复新液组大鼠溃疡面积更小，溃疡愈合率高，炎症因子水平低，相关蛋白表达量高（P < 0.05）；第14、28天时，银黄洗剂组大鼠溃疡面积小于康复新液组（P < 0.01），溃疡愈合率大于康复新液组（P < 0.01），炎症因子水平低于康复新液组（P < 0.01），相关蛋白表达量高于康复新液组（P < 0.01）。 结论： 银黄洗剂可通过抑制炎症因子及调节HIF - 1α/VEGF信号通路，促进缺血创面血管生成，加速创面组织愈合，缩短糖尿病溃疡治疗周期，起到治疗糖尿病溃疡创面的作用。
银黄洗剂
/
糖尿病溃疡
/
IL - 18
/
TNF - α
/
HIF - 1α/VEGF通路
Objective: To investigate the therapeutic effects and mechanisms of Yinhuang Lotion on wound healing in diabetic ulcer rats.Methods: A diabetic model was established in SD rats using a high - sugar, high - fat diet combined with a single intraperitoneal injection of streptozotocin (STZ). A diabetic skin ulcer model was then created through surgical intervention and stimulation with 50% glacial acetic acid. The successfully modeled rats were randomly divided into a model group, a Yinhuang Lotion group, and a Kangfuxin Liquid group, with 12 rats in each group. An additional 12 normal SD rats served as the control group. The ulcer wounds of the control and model groups were covered with gauze soaked in normal saline. The Yinhuang Lotion group received gauze soaked in Yinhuang Lotion, while the Kangfuxin Liquid group was treated with gauze soaked in Kangfuxin Liquid. All groups underwent daily dressing changes for 28 days. On days 14 and 28, six rats from each group were randomly selected to assess general condition, body weight, fasting blood glucose, ulcer area, and ulcer healing rate. Serum levels of interleukin - 18 (IL - 18) and tumor necrosis factor - α (TNF - α) were measured using ELISA, while the expression levels of hypoxia - inducible factor 1α (HIF - 1α) and vascular endothelial growth factor (VEGF) were detected via Western blot.Results: On days 14 and 28, compared with the control group, the model group exhibited larger ulcer areas, lower ulcer healing rates, higher levels of inflammatory factors, and reduced expression of related proteins (P <0.05). In contrast, the Yinhuang Lotion and Kangfuxin Liquid groups showed smaller ulcer areas, higher ulcer healing rates, lower inflammatory factor levels, and increased expression of related proteins (P <0.05). Furthermore, on days 14 and 28, the Yinhuang Lotion group demonstrated significantly smaller ulcer areas (P <0.01), higher ulcer healing rates (P < 0.01), lower inflammatory factor levels (P <0.01), and higher expression of related proteins (P < 0.01) compared with the Kangfuxin Liquid group.Conclusion: Yinhuang Lotion can promote angiogenesis in ischemic wounds, accelerate tissue repair, and shorten the treatment period for diabetic ulcers by inhibiting inflammatory factors and regulating the HIF - 1α/VEGF signaling pathway, thereby effectively treating diabetic ulcer wounds.
Yinhuang Lotion
/
Diabetic ulcer
/
IL - 18
/
TNF - α
/
HIF - 1α/VEGF pathway
王培宇, 贾振, 高杰, 梁学威.
银黄洗剂对糖尿病溃疡大鼠IL - 18、TNF - α及HIF - 1α/VEGF通路的影响.
中医药学报,
2026
, 54
(2)
: 15
-21
.
DOI: 10.19664/j.cnki.1002-2392.260026
WANG Peiyu, JIA Zhen, GAO Jie, LIANG Xuewei.
Effects of Yinhuang Lotion on IL - 18, TNF - α, and the HIF - 1α/VEGF Pathway in Diabetic Ulcer Rats[J].
Acta Chinese Medicine and Pharmacology ,
2026
, 54
(2)
: 15
-21
.
DOI: 10.19664/j.cnki.1002-2392.260026
2026年第54卷第2期
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doi: 10.19664/j.cnki.1002-2392.260026
接收时间：2024-05-09
首发时间：2026-09-09
https://castjournals.cast.org.cn/joweb/zyyxb/CN/10.19664/j.cnki.1002-2392.260026
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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